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Cu/Au/Pt-MOFs composite material with enhanced peroxidase activity as well as preparation method and application of Cu/Au/Pt-MOFs composite material

A technology of peroxidase and composite material, which is applied in the field of Cu/Au/Pt-metal organic framework composite material and its preparation, can solve the problem of easy aggregation of nanoparticles, and achieves improved catalase-like activity and low detection rate. Out-of-limit, easy-to-operate effects

Active Publication Date: 2022-04-26
CENT SOUTH UNIV
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  • Application Information

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Problems solved by technology

Co-V mixed metal oxides, Pd-Fe-modified graphite nanosheets and copper sulfide nanoparticles have been applied to interact with H 2 o 2 synergistic antibacterial, but their application is still limited by the easy aggregation of nanoparticles and the use of high concentrations of H 2 o 2 limits

Method used

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  • Cu/Au/Pt-MOFs composite material with enhanced peroxidase activity as well as preparation method and application of Cu/Au/Pt-MOFs composite material
  • Cu/Au/Pt-MOFs composite material with enhanced peroxidase activity as well as preparation method and application of Cu/Au/Pt-MOFs composite material
  • Cu/Au/Pt-MOFs composite material with enhanced peroxidase activity as well as preparation method and application of Cu/Au/Pt-MOFs composite material

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Embodiment

[0041] A Cu / Au / Pt-MOFs composite with enhanced peroxidase activity consisting of Cu-TCPP(Fe) and Cu / Au / PtNPs grown in situ on its surface, Cu-TCPP(Fe) and Cu The mass ratio of Cu / Au / Pt multimetal nanoparticles is 1:1.57, and the mass ratio of Cu, Au, and Pt in Cu / Au / Pt multimetal nanoparticles is 1:5.78:4.52.

[0042] 1. The preparation method of Cu / Au / Pt-MOFs, such as figure 2 As shown, the specific steps are as follows:

[0043] 0.012g Cu(NO 3 ) 2 ·3H 2 O (0.01 mmoL), 50 μL of trifluoroacetic acid (1.0 M) and 50.0 mg of polyvinylpyrrolidone were dissolved in a mixture of 60 mL of DMF and ethanol (V:V=3:1). A mixed solution of 0.022g TCPP(Fe) (0.005mmoL) dissolved in 20mL of DMF and ethanol (V:V=3:1) was added dropwise to the above mixed solution under stirring. Then, the solution was sonicated for 10 min, placed in a reaction kettle and heated to 80 °C for 15 h. The resulting dark brown product was washed twice with ethanol, and collected by centrifugation at 8000 rpm...

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Abstract

The invention discloses a Cu / Au / Pt-MOFs composite material capable of enhancing peroxidase activity, which belongs to the technical field of nano mimic enzyme and medical antibiosis, and is mainly composed of Cu-TCPP (Fe) and Cu / Au / PtNPs growing on the surface of the Cu-TCPP (Fe) in situ. The catalase activity of Cu / Au / PtNPs and Cu-TCPP (Fe) is utilized, synergistic dual mimic enzyme activity is achieved, catalase-like activity of Cu / Au / PtNPs and Cu-TCPP (Fe) is greatly improved, and in the presence of low-concentration H2O2, a very strong killing effect on various bacteria including common infectious bacteria such as staphylococcus aureus and salmonella is achieved; and the composition also has an excellent killing effect on pseudomonas aeruginosa which is easy to form a biological membrane. The invention further discloses a preparation method of the Cu / Au / Pt-MOFs composite material and application of the Cu / Au / Pt-MOFs composite material in preparation of an antibacterial agent. The preparation method is simple in process, easy to operate and environmentally friendly.

Description

technical field [0001] The invention belongs to the technical field of nano-mimetic enzymes and medical antibacterial, in particular to a Cu / Au / Pt-metal organic framework (Cu / Au / Pt-MOFs) composite material with peroxidase activity and its preparation method and its application in Antimicrobial applications. Background technique [0002] Diseases caused by bacterial infections are one of the global public health problems. According to statistics, millions of people die every year due to bacterial infection. Antibiotics are the traditional method to treat infectious bacteria, but the abuse of antibiotics has led to the continuous increase of bacterial resistance, and even the emergence of "super bacteria". Therefore, there is an urgent need to find new antibacterial agents. In recent years, a series of antibacterial materials such as nano silver have been used to kill bacteria because of their unique antibacterial mechanism. These antibacterial materials can react with the...

Claims

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Application Information

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IPC IPC(8): B01J31/22A01N59/00A01N43/90A01N59/20A01N59/16A01P1/00
CPCB01J31/1825A01N59/00A01N43/90A01N59/20A01N59/16B01J2531/16B01J2531/025Y02A50/30
Inventor 丁萍伍翩开天瀚何兴侯龚芳洁陈翠梅王丹琪黄瑞雪张竞文
Owner CENT SOUTH UNIV
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