Mineralized material for preventing and treating dentin hypersensitivity and resisting caries as well as preparation method and application of mineralized material

A dentin and sensitive technology, applied in dental preparations, dentistry, pharmaceutical formulations, etc., can solve problems such as demineralization and remineralization of dental hard tissues, easy to produce drug-resistant strains, and affect the sealing effect, etc., to achieve product structure stability , Stable biological activity, good safety effect

Active Publication Date: 2022-05-27
TONGJI UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Streptococcus mutans, the main cariogenic bacteria in the oral cavity, produces acidic substances by adhering to the tooth surface, which promotes the demineralization and remineralization of dental hard tissues, eventually leading to the occurrence of caries, thus affecting the sealing effect
At present, chlorhexidine, fluoride, metal ions, traditional Chinese medicine, etc. are often doped in dentin desensitization materials. Although they can provide the effect of inhibiting cariogenic bacteria, their existence is prone to drug-resistant strains, cytotoxicity, tooth discoloration, Disadvantages such as cumbersome extraction process and special taste

Method used

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  • Mineralized material for preventing and treating dentin hypersensitivity and resisting caries as well as preparation method and application of mineralized material
  • Mineralized material for preventing and treating dentin hypersensitivity and resisting caries as well as preparation method and application of mineralized material
  • Mineralized material for preventing and treating dentin hypersensitivity and resisting caries as well as preparation method and application of mineralized material

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preparation example Construction

[0028] The preparation method of the mineralized material for preventing and treating dentin sensitivity and anti-caries comprises the following steps:

[0029] Step 1, configure calcium chloride (CaCl 2 ) solution. At room temperature, dissolve 1.11 g of calcium chloride powder in 10 mL of distilled water, vortex evenly, and prepare 1 mol / L CaCl 2 solution.

[0030] Step 2, according to the mass-to-volume ratio of 2g:1L, add powdered IgY to fresh DMEM medium (DMEM solution), vortex evenly, place it in a shaker with parameters of 37°C and 180rpm, and incubate for 12 hours to obtain the first step. a mixture. The first mixed solution is a suspension.

[0031] Step 3, add 20 μL of CaCl per ml of the first mixture 2 The ratio of the solution (1mol / L), the CaCl 2 The solution (1 mol / L) was added to the first mixed solution, and the mixture was continuously placed in a shaker with parameters of 37° C. and 180 rpm for 30 min to obtain a mixture.

[0032] Step 4, quickly divid...

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Abstract

The invention provides a mineralization material for preventing and treating dentin hypersensitivity and resisting caries as well as a preparation method and application thereof, and belongs to the technical field of dental materials. The mineralization material for preventing and treating dentin hypersensitivity and resisting caries is a calcium phosphate nano biomimetic mineralization material loaded with egg yolk immunoglobulin, can effectively seal exposed dentin tubules, can effectively inhibit growth of cariogenic bacteria streptococcus mutans, and has good safety.

Description

technical field [0001] The invention relates to the technical field of dental materials, in particular to a mineralized material for preventing and treating dentin sensitivity and resisting caries, a preparation method and application thereof. Background technique [0002] Dentin sensitivity refers to an abnormal soreness that occurs when dentinal tubules are directly opened in the oral environment due to problems such as abrasion, acid erosion, caries, and wedge-shaped defects. The currently generally accepted pathogenesis of dentin hypersensitivity is the "hydrodynamic theory". Based on this theory, the opening of dentinal tubules leads to the stimulation of dentin fluid in the tubules to transmit to the pulp, which is a key factor in the development of dentin hypersensitivity. Therefore, in view of this pathogenesis, the most direct way to treat dentin hypersensitivity is to seal the dentinal tubules. For decades, researchers have used a variety of materials or methods s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K6/838A61K6/80A61K6/54A61K6/69B82Y40/00
CPCA61K6/838A61K6/80A61K6/54A61K6/69B82Y40/00Y02A50/30
Inventor 颜燕宏管贇蒋备战
Owner TONGJI UNIV
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