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Psoralen/ligustrazine microemulsion and microemulsion gel as well as preparation method and application of psoralen/ligustrazine microemulsion and microemulsion gel

A technology of psoralen and microemulsion gel, which is applied in the field of preparation of pharmaceutical preparations, can solve the problems of large side effects and poor curative effect of vitiligo, and achieve the effects of easy transportation and storage, uniform and transparent appearance, and high gel viscosity

Pending Publication Date: 2022-05-27
CHENGDU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to solve the above-mentioned technical problems, the object of the present invention is to provide a kind of psoralen / ligustrazine microemulsion and microemulsion gel and its preparation method and application, to solve the problems of poor curative effect and large side effects of existing medicines for treating vitiligo

Method used

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  • Psoralen/ligustrazine microemulsion and microemulsion gel as well as preparation method and application of psoralen/ligustrazine microemulsion and microemulsion gel
  • Psoralen/ligustrazine microemulsion and microemulsion gel as well as preparation method and application of psoralen/ligustrazine microemulsion and microemulsion gel
  • Psoralen/ligustrazine microemulsion and microemulsion gel as well as preparation method and application of psoralen/ligustrazine microemulsion and microemulsion gel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] A kind of psoralen / ligustrazine microemulsion, its preparation method comprises the following steps:

[0049] (1) 28.2mg psoralen, 241.1mg ligustrazine, 2.135g Tween 80 and 2.135g isopropanol were vortex-mixed until completely dissolved to obtain a mixed solution;

[0050] (2) Add 1.54g of polyethylene glycol glycerol oleate to the mixed solution, stir magnetically for 30min at 35°C, then add 4.19g of pure water dropwise, stir for 30min, to obtain psoralen / ligustrazine microparticles milk;

[0051] A kind of psoralen / ligustrazine microemulsion gel, its preparation method comprises the following steps:

[0052] Take 101.5 mg of Carbomer 940 in a beaker, add 50 mL of pure water, leave it for 12 hours to fully swell, then add the above-mentioned psoralen / Ligustrazine microemulsion, and stir at 35°C for 30 minutes to obtain psoralen / Ligustrazine Zine microemulsion gel; volume ratio of psoralen / ligustrazine microemulsion and swelled carbomer 940 was 1:1.

Embodiment 2

[0054] A kind of psoralen / ligustrazine microemulsion, its preparation method comprises the following steps:

[0055] (1) 20.4mg psoralen, 153.6mg ligustrazine, 1.536g Tween 80 and 1.536g isopropanol were vortex-mixed until completely dissolved to obtain a mixed solution;

[0056] (2) Add 1.024g of polyethylene glycol glycerol oleate to the mixed solution, stir magnetically for 30min at 35°C, then add 5.971g of pure water dropwise, stir for 30min, to obtain psoralen / ligustrazine microparticles milk;

[0057] A kind of psoralen / ligustrazine microemulsion gel, its preparation method comprises the following steps:

[0058] Take 101.5 mg of Carbomer 940 in a beaker, add 100 mL of pure water, leave it for 12 hours to fully swell, then add the above-mentioned psoralen / Ligustrazine microemulsion, and stir at 35°C for 30 minutes to obtain psoralen / Ligustrazine The volume ratio of psoralen / ligustrazine microemulsion and swelled carbomer 940 was 1:0.8.

Embodiment 3

[0060] A kind of psoralen / ligustrazine microemulsion, its preparation method comprises the following steps:

[0061] (1) 30.7mg psoralen, 256.05mg ligustrazine, 2.56g Tween 80 and 2.56g isopropanol were vortex-mixed until completely dissolved to obtain a mixed solution;

[0062] (2) Add 2.048g of polyethylene glycol glycerol oleate to the mixed solution, stir magnetically for 30min at 35°C, then add 2.785g of pure water dropwise, and stir for 30min to prepare psoralen / ligustrazine microparticles. milk;

[0063] A kind of psoralen / ligustrazine microemulsion gel, its preparation method comprises the following steps:

[0064] Take 101.5 mg of Carbomer 940 in a beaker, add 34 mL of pure water, leave it for 12 hours to fully swell, then add the above-mentioned psoralen / Ligustrazine microemulsion, and stir at 35°C for 30 minutes to obtain psoralen / Ligustrazine Zine microemulsion gel; volume ratio of psoralen / ligustrazine microemulsion and swelled carbomer 940 was 1:1.2.

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Abstract

The invention discloses a psoralen / ligustrazine microemulsion and microemulsion gel as well as a preparation method and application of the psoralen / ligustrazine microemulsion and microemulsion gel. The psoralen / ligustrazine microemulsion comprises the following components: 0.2 to 0.3 mt% of psoralen, 1.5 to 2.5 mt% of ligustrazine, 15 to 25 mt% of an emulsifier, 15 to 25 mt% of a co-emulsifier, 10 to 20 mt% of an oil phase and the balance of pure water. According to the invention, ligustrazine and psoralen are combined to prepare a microemulsion or microemulsion gel preparation, the synergistic effect among the medicine components is comprehensively exerted through the multi-target effect, and the whole effect is exerted by combining with various promotion effects of the preparation, so that the leucoderma can be effectively treated.

Description

technical field [0001] The invention relates to the technical field of preparation of pharmaceutical preparations, in particular to a psoralen / ligustrazine microemulsion and microemulsion gel and a preparation method and application thereof. Background technique [0002] Vitiligo is a common acquired skin depigmentation disease. Recent studies have shown that vitiligo is caused by the loss of some functions of melanocytes in the patient's skin, so that melanin cannot be synthesized normally. The mechanism is not yet clear, but it is generally believed to be related to three factors: genetics, oxidative stress and autoimmunity. Oxidative stress is based on certain functional defects in melanocytes in patients with vitiligo, which are more susceptible to changes in cell metabolism. During the formation of melanin, melanocytes generate a large amount of free radicals through hydroxylation and oxidation, and the content of reactive oxygen species (ROS) cannot be metabolized in t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4965A61K9/107A61K47/14A61K47/32A61K9/06A61P17/00A61K31/37
CPCA61K31/37A61K31/4965A61K9/1075A61K47/14A61P17/00A61K9/06A61K47/32A61K9/0014A61K2300/00Y02A50/30
Inventor 李维邹亮曾山宋雨陈洲江刘瑛陈乐唐子茹
Owner CHENGDU UNIV
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