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Preparation method of unsaturated fatty acid with weight-losing and lipid-lowering effects

A technology of unsaturated fatty acids and fatty acids, which is applied in the direction of fatty acid preparation/refining, fatty acid production, etc., can solve the problems of dietary supplements or nutritional health products, and achieve weight reduction, blood sugar and blood lipid levels, fat cell size reduction, and weight loss. The effect of fat accumulation

Pending Publication Date: 2022-05-27
FUJIAN AGRI & FORESTRY UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Currently, there are no dietary supplements or nutritional health products related to weight loss and fat reduction that use chlorella unsaturated fatty acids as raw materials on the market

Method used

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  • Preparation method of unsaturated fatty acid with weight-losing and lipid-lowering effects
  • Preparation method of unsaturated fatty acid with weight-losing and lipid-lowering effects
  • Preparation method of unsaturated fatty acid with weight-losing and lipid-lowering effects

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Preparation of Chlorella unsaturated fatty acids:

[0030] (1) Preparation of Chlorella fatty acid concentrate

[0031] 1. Mix the spray-dried Chlorella dry powder with distilled water at 90°C at a ratio of 1:9 g / mL, take 200ml of Chlorella aqueous solution and heat it with saturated steam at a pressure of 1.5MPa and a temperature of 120°C in a steam explosion apparatus. Instant blasting after 10 minutes to obtain a chlorella wall-breaking solution;

[0032] 2. Mix the chlorella wall-breaking solution with 0.5 mol / L KOH / methanol solution in a volume ratio of 10:3;

[0033] 3. Heating at a constant temperature of 60 degrees Celsius, and stirring for 1 hour, mixing and saponification;

[0034] 4. Perform suction filtration on the mixed solution;

[0035] 5. Discard the chlorella residue and collect the filtrate;

[0036] 6. Use hydrochloric acid to adjust the pH of the filtrate to acidic (pH3);

[0037] 7. Use n-hexane for extraction under acidic conditions to obtain...

Embodiment 2

[0050] Study of Chlorella unsaturated fatty acids on weight loss and lipid reduction in obese mice.

[0051] experimental method:

[0052] The Chlorella unsaturated fatty acids extracted in Example 1 were fed to mice in different proportions.

[0053] Thirty-six 4-week-old clean-grade C57BL / 6J male mice (14–16 g) were housed in an environment with a temperature of 23 °C ± 1 °C, a humidity of 55% ± 5%, and a 12-hour light / dark cycle. After 1 week of adaptation, they were randomly divided into 6 groups (n=6), among which except the normal group (Normal Diet, ND), which was fed with normal feed, the other five groups were high-fat group (High Fat Diet, HFD), low-dose group (Unsaturated Fatty Acid 1, UFA1), high-dose group (Unsaturated Fatty Acid 2, UFA2), chlorella powder group (Dry ChlorellaPowder, DCP), flaxseed oil group (Flaxseed Oil, FO) were fed with high-fat diet. All mice were treated by gavage. The ND group was given normal saline, the HFD group and DCP group were gi...

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Abstract

The invention discloses a preparation method of unsaturated fatty acid with weight-losing and lipid-lowering effects. Chlorella powder is subjected to auxiliary extraction by using a KOH / methanol solution, enrichment and inclusion are carried out by using a urea / methanol solution, and the unsaturated fatty acid of chlorella is finally obtained through the technical means of suction filtration, extraction, concentration and the like. The main component of the unsaturated fatty acid is polyunsaturated fatty acid linoleic acid. The weight-losing and lipid-lowering effects of the unsaturated fatty acid are mainly reflected in improvement of body weight, regulation of blood sugar and blood lipid levels, and reduction of fat accumulation and liver injury.

Description

technical field [0001] The invention belongs to the application field of natural products, in particular to an unsaturated fatty acid with weight loss and lipid-lowering effects extracted from natural marine biological source material. Background technique [0002] Obesity is a public health problem that has attracted worldwide attention and is a disease caused by the imbalance of human energy metabolism. In recent years, its incidence has increased significantly, and it has a tendency to be younger and more frequent in adolescents. Obesity is mainly manifested as changes in body shape caused by overweight and fat accumulation, which not only affects physical health, but also causes certain harm to mental health. In addition, the harm of obesity is mainly manifested in some effects on other diseases, such as hypertension, hyperlipidemia, diabetes, cardiovascular disease, etc., increasing the risk of disease. As people pay more and more attention to obesity, in order to avo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C11C1/00C11C1/08
CPCC11C1/005C11C1/002C11C1/08
Inventor 林少玲杨阳赖丹宁陈清燕施源
Owner FUJIAN AGRI & FORESTRY UNIV
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