Ultralow elastic modulus antibacterial medical tantalum alloy and preparation method thereof

Abstract

The invention discloses an ultra-low elastic modulus antibacterial medical tantalum alloy which comprises the following components in percentage by mass: 5-20% of titanium, 1-5% of copper and the balance of tantalum. The tantalum alloy is prepared through two steps of mechanical alloying (MA) and spark plasma sintering (SPS). The compressive strength of the tantalum alloy is 700-1200 MPa, the elasticity modulus of the tantalum alloy is 6-15 GPa, the elasticity modulus of the tantalum alloy is matched with a human bone, the defect that a stress shielding effect is generated between an implant and a bone interface after the implant with high elasticity modulus is implanted is overcome, meanwhile, postoperative infection caused by a medical metal tantalum implant is reduced, and the service life of the implant is prolonged; the tantalum alloy has excellent antibacterial performance, corrosion resistance and biocompatibility, the antibacterial rate is increased along with increase of the copper content, the antibacterial rate of escherichia coli can reach 92.6%, and the antibacterial rate of staphylococcus aureus can reach 84.6%. The tantalum alloy is very suitable for being used as a medical implant material of dentale.

Description

technical field [0001] The invention belongs to the field of medical metal materials, in particular to an ultra-low elastic modulus antibacterial medical tantalum alloy and a preparation method thereof. Background technique [0002] Tantalum has attracted widespread attention in the biomedical field due to its excellent chemical stability, corrosion resistance and biocompatibility, and has broad application prospects in the medical field. But the medical metal tantalum still has many problems: (1) The elastic modulus of tantalum (about 190GPa) is much higher than that of human bones (10-30GPa). The interface of the bone produces a "stress shielding effect", and long-term use will cause bone resorption and osteoporosis, resulting in the loosening of the implant and shortening the service life; (2) the problem of postoperative infection caused by the implant is more and more frequent, and It has become an urgent clinical problem. According to the data released by the World He...

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Problems solved by technology

However, there are still many problems with medical metal tantalum: (1) The elastic modulus of tantalum (about 190GPa) is much higher than that of human bones (10-30GPa), and the serious mismatch of elastic modulus will make the implant and The interface of the bone produces a "stress shielding effect". Long-term use will cause bone resorption and osteoporosis, resulting in loosening of the implant and shortening its service life; (2) Postoperative infection caused by the implant is becoming more and more frequent, It has become an urgent problem to be solved clinically. According to the data released by the World Health Organization, more than 14 million people suffer from bacterial infections every year, and 60% of bacterial infections are related to the use of implants.

[0003] At present, a large number of studies have shown that titanium-tantalum alloys have high elastic modulus and low compressive strength, which easily lead to stress shielding effect.

In addition, some studies have shown that titanium-tantalum alloys do not have antibacterial function, and it is easy to cause bacterial infection after implantation. In severe cases, it will lead to complications and eventually lead to implant failure.

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