Ultralow elastic modulus antibacterial medical tantalum alloy and preparation method thereof

A technology of elastic modulus and tantalum alloy, which is applied in medical science, disease resistance to media transmission, prosthesis, etc., can solve the problems of frequent postoperative infection, titanium-tantalum alloy does not have antibacterial function, stress shielding effect and other problems, and achieves Long-lasting and efficient antibacterial and anti-infective properties, the effect of solving bacterial infections

Active Publication Date: 2022-05-27
EAST CHINA JIAOTONG UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are still many problems with medical metal tantalum: (1) The elastic modulus of tantalum (about 190GPa) is much higher than that of human bones (10-30GPa), and the serious mismatch of elastic modulus will make the implant and The interface of the bone produces a "stress shielding effect". Long-term use will cause bone resorption and osteoporosis, resulting in loosening of the implant and shortening its service life; (2) Postoperative infection caused by the implant is becoming more and more frequent, It has become an urgent problem to be solved clinically. According to the data released by

Method used

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  • Ultralow elastic modulus antibacterial medical tantalum alloy and preparation method thereof
  • Ultralow elastic modulus antibacterial medical tantalum alloy and preparation method thereof
  • Ultralow elastic modulus antibacterial medical tantalum alloy and preparation method thereof

Examples

Experimental program
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Embodiment 1

[0025] Example 1, Ta-10Ti-3Cu powder alloying

[0026] Weigh tantalum powder with a mass of about 34.8g, titanium powder with a mass of about 4.0g and copper powder with a mass of about 1.2g (the mass ratio of tantalum: titanium: copper is 87:10:3) Ball milling is carried out in a ball milling tank to obtain powder; the ball milling process parameters are the same as those in Comparative Example 1.

Embodiment 2

[0036] Embodiment 2, the preparation of Ta-10Ti-3Cu bulk alloy, the steps are as follows:

[0037] Step 1) Mechanical alloying of powders: Weigh out tantalum powder with a mass of about 34.8 g, titanium powder with a mass of about 4.0 g, and copper powder with a mass of about 1.2 g (the mass ratio of tantalum: titanium: copper is 87:10). 3) put into the ball-milling tank of inert gas protection and carry out ball-milling, obtain powder; Ball-milling process parameter is identical with embodiment 1;

[0038]Step 2) Spark plasma sintering: put the powder obtained in step 1) into a graphite mold with a diameter of 20 mm, and then put the mold into a spark plasma sintering furnace for sintering to obtain a medical tantalum alloy; sintering forming process parameters: sintering temperature: 900 ℃, pressure: 50MPa, hold for 5min. The Ta-10Ti-1Cu alloy is obtained, which is denoted as Ta-10Ti-3Cu alloy, and its density is 98% after measurement.

Embodiment 3

[0042] Example 3. Preparation of Ta-5Ti-3Cu bulk alloy. The difference between its preparation method and Example 2 is that the content of Ti added in step 1) is changed from 3% to 5%, that is, tantalum powder with a mass of about 36.8g, titanium powder with a mass of about 2.0g and Copper powder with a mass of about 1.2g (the mass ratio of tantalum:titanium:copper is 92:5:3) is obtained after the ball-milled powder is sintered by spark plasma.

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Abstract

The invention discloses an ultra-low elastic modulus antibacterial medical tantalum alloy which comprises the following components in percentage by mass: 5-20% of titanium, 1-5% of copper and the balance of tantalum. The tantalum alloy is prepared through two steps of mechanical alloying (MA) and spark plasma sintering (SPS). The compressive strength of the tantalum alloy is 700-1200 MPa, the elasticity modulus of the tantalum alloy is 6-15 GPa, the elasticity modulus of the tantalum alloy is matched with a human bone, the defect that a stress shielding effect is generated between an implant and a bone interface after the implant with high elasticity modulus is implanted is overcome, meanwhile, postoperative infection caused by a medical metal tantalum implant is reduced, and the service life of the implant is prolonged; the tantalum alloy has excellent antibacterial performance, corrosion resistance and biocompatibility, the antibacterial rate is increased along with increase of the copper content, the antibacterial rate of escherichia coli can reach 92.6%, and the antibacterial rate of staphylococcus aureus can reach 84.6%. The tantalum alloy is very suitable for being used as a medical implant material of dentale.

Description

technical field [0001] The invention belongs to the field of medical metal materials, in particular to an ultra-low elastic modulus antibacterial medical tantalum alloy and a preparation method thereof. Background technique [0002] Tantalum has attracted widespread attention in the biomedical field due to its excellent chemical stability, corrosion resistance and biocompatibility, and has broad application prospects in the medical field. But the medical metal tantalum still has many problems: (1) The elastic modulus of tantalum (about 190GPa) is much higher than that of human bones (10-30GPa). The interface of the bone produces a "stress shielding effect", and long-term use will cause bone resorption and osteoporosis, resulting in the loosening of the implant and shortening the service life; (2) the problem of postoperative infection caused by the implant is more and more frequent, and It has become an urgent clinical problem. According to the data released by the World He...

Claims

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Application Information

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IPC IPC(8): C22C27/02C22C1/04B22F9/04B22F3/105A61L27/04A61L27/06A61L27/54
CPCC22C27/02C22C1/045B22F9/04B22F3/105A61L27/047A61L27/06A61L27/54B22F2009/041B22F2009/043B22F2003/1051A61L2300/102A61L2300/404A61L2430/02Y02A50/30
Inventor 胡剑万现鹏陈绵邱靖曹亮李永祥王小巧黄海易志坚丁正
Owner EAST CHINA JIAOTONG UNIVERSITY
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