Unlock instant, AI-driven research and patent intelligence for your innovation.

Starch film-forming composition and application thereof in soft capsule

A composition and a technology for soft capsules, which are applied in the field of medicine and dietary supplement manufacturing, can solve problems such as large differences in gel properties, poor soft capsule molding performance, easy pre-gelation, etc., and achieve simple ingredients and meet industrial production requirements. Effect

Pending Publication Date: 2022-06-21
SIRIO PHARMA CO LTD
View PDF8 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The inventors have found the following technical problems in long-term research: high-acyl gellan gum and low-acyl gellan gum replace gelatin to prepare soft capsules, but due to the large difference in gelation temperature between high-acyl gellan gum and low-acyl gellan gum , leading to easy pre-gelation during the molding process of the soft capsule shell, rough rubber surface, and the large difference in gel properties between high-acyl gellan gum and low-acyl gellan gum also leads to poor molding performance of soft capsules during compression molding , easy to leak oil at the crevices

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Starch film-forming composition and application thereof in soft capsule
  • Starch film-forming composition and application thereof in soft capsule
  • Starch film-forming composition and application thereof in soft capsule

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0046] The starch film-forming composition of the present invention can be prepared into soft capsule shells by conventional techniques. For example, the preparation method may include: sol, pelletizing and drying steps. The sol step may include premixing and dispersing the first gellan gum, the second gellan gum and the plasticizer uniformly, adding to an appropriate amount of water with stirring, heating and stirring at 60-98° C. until the gellan gum is dissolved; adding starch, and continuing Heating and stirring at 60-98° C. until the starch dissolves; removing the air bubbles to obtain a glue solution. The pill pressing step may include using a soft capsule production line to transport the glue into the plastic box of the soft capsule filling machine, and the glue is cooled on the surface of the drum to form a rubber, which is compressed and formed by packaging and filling, and can be further shaped in a rotating cage. The prepared soft capsule shells were tested to be e...

Embodiment 1-7

[0092] According to the formulation composition of Table 2, Table 3 and Table 4 and according to the preparation method of the soft capsule skin above, the soft capsule skins of Examples 1-7 were prepared and the capsule skins of Comparative Examples 1-10 were prepared, and the soft capsule skins were determined as described above. Capsule skin strength, toughness and molding adhesion index and enteric solubility.

[0093] Table 2: Film-forming composition formulations and effect measurements of Examples 1-7

[0094]

[0095] √ not cracked, × cracked, / not tested.

[0096] Table 3: Film-forming composition formulation and effect measurement of Comparative Examples 1-5

[0097]

[0098] √ not cracked, × cracked, / not tested.

[0099] Table 4: Film-forming composition formulation and effect measurement of Comparative Examples 6-10

[0100]

[0101] According to Table 2, Table 3 and Table 4, when the comprehensive evaluation is greater than 3, the molding performanc...

Embodiment 8-14

[0106] According to the formula composition of Table 6 and according to the preparation method of the above soft capsule skin, the soft capsule skins of Examples 8-14 were prepared, and the soft capsule skin strength, toughness and molding adhesion index and enteric solubility were determined as described above.

[0107] Softgels were prepared with the ingredients and amounts described in Table 6, and tested and scored. The measurement results are shown in Table 6.

[0108] Table 6: Film-forming composition formulations and tested effects of Example 3 and Examples 8-14.

[0109]

[0110] √ means no rupture × means rupture; USP refers to USP disintegration time limit; in simulated gastric juice (1h); in simulated intestinal juice (1h); European Pharmacopoeia refers to European Pharmacopoeia disintegration time limit; in 0.1M hydrochloric acid (2h); in phosphate buffer pH 6.8 (1h)

[0111] Examples 8-14 illustrate the preparation of soft capsules containing two kinds of p...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides a starch film-forming composition and application thereof in soft capsules. The present invention relates to a starch film-forming composition comprising 0.5-8 wt% of a first gellan gum, 0.5-8 wt% of a second gellan gum, 16-45 wt% of starch, 10-35 wt% of a plasticizer, the starch film-forming composition further comprising water wherein the first gellan gum and the second gellan gum are gellan gum in which each repeating unit of the gellan gum contains 25%-40% of acetyl groups and 15%-45% of glycerol acyl groups, the acetyl content of the second gellan gum is greater than the acetyl content of the first gellan gum by 5%-13%, and / or the glyceroyl content of the second gellan gum is greater than the glyceroyl content of the first gellan gum by 5%-25%. The soft capsule prepared from the starch film-forming composition disclosed by the invention is good in film-forming property, good in toughness and good in forming property, and has an enteric-coated effect.

Description

technical field [0001] The invention belongs to the field of manufacture of medicines and dietary supplements, and in particular relates to a starch composition and the application of the starch composition in vegetable soft capsules. Background technique [0002] Soft capsules refer to the direct coating of quantitative liquid medicines, nutritional ingredients, etc., or to dissolve or disperse solid medicines and nutritional ingredients with suitable excipients to make solutions, suspensions, emulsions or semi-solids, sealed in spherical or elliptical forms. Capsules in soft capsules. Soft capsules can be prepared into enteric soft capsules according to the properties of the drug. Enteric-coated soft capsules add special medicinal polymer materials or special treatment to the capsule shell. It does not dissolve in gastric juice, but only disintegrates and dissolves in intestinal juice to release active ingredients, achieving an enteric effect. "Chinese Pharmacopoeia" sti...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K9/48A61K47/36A23P10/30
CPCA61K9/4816A61K47/36A61K9/4833A23P10/30Y02W90/10
Inventor 方素琼李绪发陈洁伟
Owner SIRIO PHARMA CO LTD