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Antibacterial healing-promoting functional dressing and preparation method thereof

A functional and functional technology, applied in bandages, absorbent pads, medical science, etc., can solve the problems of unfavorable wound healing, short residence time, dry wound, etc., and achieve the effect of prolonging residence time, simple operation and high output

Pending Publication Date: 2022-06-28
GUOKE RUINUO (ZHONGSHAN) BIOTECHNOLOGY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, as these functional substances attached to the surface of the foam dressing are dissolved by the wound exudate, the formed solution stays in the wound for a short time, and the solution volatilizes and causes the wound to dry, which is not conducive to wound healing

Method used

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  • Antibacterial healing-promoting functional dressing and preparation method thereof
  • Antibacterial healing-promoting functional dressing and preparation method thereof
  • Antibacterial healing-promoting functional dressing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] like figure 1 and 2 As shown, an antibacterial and healing-promoting functional dressing includes a backing layer 1, a polyurethane foam layer 2 and an antibacterial and healing-promoting functional layer 3 that are adhered in sequence. and thickening agent, the mass fraction of the antibacterial and healing-promoting functional component is 0.03%-20%, and the antibacterial and healing-promoting functional component is composed of one or more water-soluble shells with good solubility, antibacterial properties and the function of promoting skin cell proliferation. Glycan composition. The backing layer 1 is an adhesive breathable non-woven fabric or a waterproof polyurethane film; the shapes include but are not limited to conventional shapes such as circles and squares, or special shapes such as heel-shaped and sacral-shaped; the area is not smaller than the polyurethane foam dressing covered above area. In another embodiment, the backing layer 1 can be selected accord...

Embodiment 2

[0048] like figure 1 and 2 As shown in the figure, an antibacterial and healing-promoting functionalized dressing of this embodiment is composed of a bottom lining layer 1, a polyurethane foam layer 2, an antibacterial healing-promoting functional layer 3 and a peeling layer in order from bottom to top; the bottom lining layer 1 It is a 10cm×10cm viscous and breathable non-woven fabric; the polyurethane foam layer 2 is composed of a 7cm×7cm polyurethane foam material with a thickness of 4mm; Formed after drying at 25°C, the viscous polymer aqueous solution is obtained by fully mixing and dissolving 0.35 parts of biguanide-modified chitosan, 5 parts of polyethylene glycol 400, and 2.2 parts of hydroxyethyl cellulose in 100 parts of deionized water. into; the peeling layer has a gram weight of 40-90g / m 2 composition of 10cm x 10cm glassine silicone oil paper.

[0049] When in use, peel off the peeling layer, align the antibacterial and healing-promoting functional layer 3 at ...

Embodiment 3

[0055] An antibacterial and healing-promoting functional dressing of this embodiment is composed of a bottom lining layer 1, a polyurethane foam layer 2, an antibacterial healing-promoting functional layer 3 and a peeling layer in order from bottom to top; the bottom lining layer 1 is butterfly-shaped Waterproof polyurethane film; polyurethane foam layer 2 is composed of 10cm×10cm polyurethane foam material with a thickness of 4mm; antibacterial healing-promoting functional layer 3 is formed after the antibacterial healing-promoting viscous polymer aqueous solution is uniformly coated on the foam layer and dried at 20°C. The viscous polymer aqueous solution is composed of 0.2 parts of bichitosan-antibacterial peptide conjugate, 4 parts of polyethylene glycol 600, and 3 parts of hydroxypropyl cellulose in 100 parts of PBS buffer (pH=7.2-7.4 , 0.01M) is fully mixed and dissolved; the peeling layer is composed of a gram weight of 40-90g / m 2 butterfly shaped glassine paper composi...

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Abstract

The invention discloses an antibacterial and healing-promoting functional dressing which comprises a bottom lining layer, a polyurethane foam layer and an antibacterial and healing-promoting functional layer which are sequentially bonded, the antibacterial and healing-promoting functional layer comprises, by mass, 0.03-20% of antibacterial and healing-promoting functional components, 0.03-20% of a humectant and 0.1-10% of a thickener, and the sum of the mass fractions of the antibacterial and healing-promoting functional components and the mass fractions of the humectant and the thickener is 100%. The antibacterial and healing-promoting functional component is composed of one or more water-soluble chitosan which is good in solubility, antibacterial and capable of promoting skin cell proliferation. A high polymer material with antibacterial and healing-promoting functions is mixed with a polymer with moisturizing and swelling characteristics, so that the antibacterial property and biocompatibility of the material are retained. The viscous functionalized polymer solution keeps the function of absorbing wound exudate while endowing the foam dressing with functionality; the wound exudate adsorbed by the dressing can also be used as a solvent, so that the dry antibacterial healing-promoting macromolecules are quickly swelled and dissolved to recover a semi-gel state, and a moist environment of the wound is stably and continuously kept.

Description

technical field [0001] The invention relates to the technical field of medical dressings, in particular to an antibacterial and healing-promoting functional dressing and a preparation method thereof. Background technique [0002] The skin is the natural protective barrier of the human body. After a wound, burn or ulcer, a large amount of wound exudate containing pus, toxins and toxic products is easily produced. If these harmful substances stay in the wound for a long time, it will hinder the healing of the wound. Using wound dressing to absorb exudate, cover and protect the wound surface is one of the more effective methods in the existing technical means of wound surface treatment. The global outbreak of bacterial drug resistance, the increasingly serious problem of population aging, the continuous increase in the incidence of diabetes and obesity, the multidrug-resistant bacterial infection wounds and chronic wound care such as diabetic foot ulcers, bedsores, and venous l...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/46A61L15/44A61L15/26A61L15/28A61L15/42A61L15/60
CPCA61L15/46A61L15/44A61L15/26A61L15/28A61L15/42A61L15/60A61L2300/236A61L2300/404A61L2300/412C08L75/04C08L5/08
Inventor 朱萌黄沙李曌
Owner GUOKE RUINUO (ZHONGSHAN) BIOTECHNOLOGY CO LTD
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