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Pit and fissure sealing agent for permeating and sealing tooth occlusal surface pits and fissures and application of pit and fissure sealing agent

A pit and fissure sealing and tooth technology, which is applied in the field of pit and fissure sealants, can solve the problems of difficulty in mass synthesis and preparation of materials, large particle size of materials, poor infiltration performance, etc., and achieve the effects of preventing dental caries, simple preparation and mild reaction conditions.

Pending Publication Date: 2022-07-01
SHAANXI NORMAL UNIV +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these methods have many defects that limit their application in actual treatment, including extreme reaction conditions, biological toxicity and safety considerations, large particle size of the material, poor infiltration performance, and difficulty in batch synthesis of the material, etc.

Method used

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  • Pit and fissure sealing agent for permeating and sealing tooth occlusal surface pits and fissures and application of pit and fissure sealing agent
  • Pit and fissure sealing agent for permeating and sealing tooth occlusal surface pits and fissures and application of pit and fissure sealing agent
  • Pit and fissure sealing agent for permeating and sealing tooth occlusal surface pits and fissures and application of pit and fissure sealing agent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] 48 mg of polyethylene glycol-2000, 52 mg of lysozyme, 12 mg of tris(2-carboxyethyl) phosphonic acid, 10 mg of calcium chloride, and 60 mg of sodium bicarbonate were uniformly mixed to obtain a pit and fissure sealant.

Embodiment 2

[0048] 50 mg of polyethylene glycol-2000, 64 mg of lysozyme, 15 mg of tris(2-carboxyethyl) phosphonic acid, 15 mg of calcium chloride, and 70 mg of sodium bicarbonate were uniformly mixed to obtain a pit and fissure sealant.

Embodiment 3

[0050] 60 mg of polyethylene glycol-2000, 74 mg of lysozyme, 20 mg of tris(2-carboxyethyl) phosphonic acid, 10 mg of calcium chloride, and 80 mg of sodium carbonate were uniformly mixed to obtain a pit and fissure sealant.

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Abstract

The invention provides a pit and fissure sealant for permeating and sealing pits and fissures on an occlusal surface of teeth and application of the pit and fissure sealant. The pit and fissure sealant comprises the following raw materials in parts by weight: 1-15 parts of polyethylene glycol, 1-20 parts of protein, 1-10 parts of a disulfide bond reducing agent or a disulfide bond oxidizing agent, 1-3 parts of calcium chloride and 2-20 parts of a pH regulator. The nest and fissure sealing agent can be prepared by physically mixing protein and polyethylene glycol through a one-pot method, and is simple in preparation, mild in reaction condition and good in controllability.

Description

technical field [0001] The invention relates to the technical field of biological materials, in particular to a pit and fissure sealant for infiltrating and sealing pits and fissures on the occlusal surface of teeth and its application. Background technique [0002] According to the World Health Organization, dental caries is one of the ten most common diseases in the world, affecting 60% to 90% of school-age children, nearly 91% of adults suffering from dental caries, and the incidence of dental caries in the elderly can reach 98%. For many people, tooth decay begins in early childhood and continues throughout life. Studies have shown that although the occlusal surface accounts for less than 15% of all tooth surfaces, more than 50% of caries occur in the pits and fissures of the occlusal surface of the teeth. Pit and fissures are deep depressions located on the occlusal surface of the teeth, with different shapes, among which I type, IK type and inverted Y type account for...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K6/20A61K6/69A61K6/70A61K6/60
CPCA61K6/20A61K6/69A61K6/70A61K6/60
Inventor 杨鹏胡博文郭晓贺
Owner SHAANXI NORMAL UNIV
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