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Cinnamaldehyde solid lipid nanoparticles with high stability and preparation method thereof

A technology of solid lipid nanometer and cinnamaldehyde, which is applied in the directions of food forming, resistance to vector-borne diseases, and preservation of fruits and vegetables, etc., can solve the problems of prolonging the preservative time of preservatives, and achieves easy industrialization promotion, high uniformity and dispersion. good effect

Pending Publication Date: 2022-07-08
珠海科技学院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Chinese patent CN109056083B discloses "a preparation method of cinnamaldehyde essential oil liposome antibacterial bilayer membrane with adjustable release" using dipalmitoylphosphatidylglycerol, distearoylphosphatidylcholine choline, cholesterol and cinnamaldehyde essential oil as The cinnamaldehyde heat-sensitive essential oil liposome prepared from raw materials has the effect of sustainably releasing anti-corrosion bacteria within five days, but the anti-corrosion time of this preservative can be further extended

Method used

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  • Cinnamaldehyde solid lipid nanoparticles with high stability and preparation method thereof
  • Cinnamaldehyde solid lipid nanoparticles with high stability and preparation method thereof
  • Cinnamaldehyde solid lipid nanoparticles with high stability and preparation method thereof

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Embodiment 1

[0026] A preparation method of cinnamaldehyde solid lipid nanoparticles with high stability, comprising the following steps:

[0027] Step 1, fully mixing and stirring soybean lecithin, poloxamer-188 and water with a mass ratio of 1:2:100 to form an aqueous solution, the stirring speed is 500rpm / min, and the stirring temperature is 70°C;

[0028] Step 2, fully mixing and stirring glyceryl monostearate, Tween-80 and cinnamaldehyde with mass ratio of 3:3:5 into an oil phase solution, the stirring speed is 1000rpm / min, and the stirring temperature is 65°C;

[0029] Step 3, drop the aqueous phase solution into the oil phase solution, the volume ratio is 100:3, and fully mix and stir, and then circulate into a lipid nanoparticle solution on a high-pressure homogenizer, the stirring speed is 500rpm / min, and the stirring temperature is 60 ℃, the pressure of high-pressure homogenization is 7,500psi, and the number of cycles is 2;

[0030] Step 4, ultrafiltration of the liposome nanop...

Embodiment 2

[0033] A preparation method of cinnamaldehyde solid lipid nanoparticles with high stability, comprising the following steps:

[0034] Step 1, fully mixing and stirring soybean lecithin, poloxamer-188 and water with a mass ratio of 3:4:100 into an aqueous solution, the stirring speed is 1000rpm / min, and the stirring temperature is 70°C;

[0035] Step 2, fully mixing and stirring glyceryl monostearate, Tween-80 and cinnamaldehyde with mass ratio of 1:1:2 into an oil phase solution, the stirring speed is 500rpm / min, and the stirring temperature is 65°C;

[0036] Step 3, drop the aqueous phase solution into the oil phase solution, the volume ratio is 100:10, and fully mix and stir, and then circulate into a liposome nanoparticle solution on a high-pressure homogenizer, the stirring speed is 1000rpm / min, and the stirring temperature is 60℃, the pressure of high pressure homogenization is 25,000psi, and the number of cycles is 4;

[0037] Step 4, ultrafiltration of the liposome nan...

Embodiment 3

[0040] A preparation method of cinnamaldehyde solid lipid nanoparticles with high stability, comprising the following steps:

[0041] Step 1, fully mixing and stirring soybean lecithin, poloxamer-188 and water with a mass ratio of 2:3:100 into an aqueous solution, the stirring speed is 750rpm / min, and the stirring temperature is 65°C;

[0042] Step 2, fully mixing and stirring glyceryl monostearate, Tween-80 and cinnamaldehyde with mass ratio 2:2:3.5 into oil phase solution, stirring speed is 750rpm / min, and stirring temperature is 60 ℃;

[0043] Step 3, drop the aqueous phase solution into the oil phase solution, the volume ratio is 100:6.5, and fully mix and stir, and then circulate into a liposome nanoparticle solution on a high-pressure homogenizer, the stirring speed is 750rpm / min, and the stirring temperature is 65℃, the pressure of high-pressure homogenization is 15,000psi, and the number of cycles is 3;

[0044] Step 4, ultrafiltration of the liposome nanoparticle sol...

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Abstract

The invention relates to the technical field of liposomes, and discloses cinnamyl aldehyde solid lipid nanoparticles with high stability and a preparation method thereof, the cinnamyl aldehyde solid lipid nanoparticles comprise cinnamyl aldehyde and a lipid encapsulation film encapsulated on the outer surface of the cinnamyl aldehyde; and the chemical components of the lipid encapsulation membrane comprise soybean lecithin, poloxamer-188, glyceryl monostearate and tween-80. Soybean lecithin is a main component of the liposome and has amphipathy, the particle size stability of the liposome can be effectively controlled after the poloxamer-188, the glyceryl monostearate and the tween-80 are mixed with the soybean lecithin, and the glyceryl monostearate plays a role in reducing the flowability of the soybean lecithin. The cinnamyl aldehyde solid lipid nanoparticles have the advantages that the cinnamyl aldehyde solid lipid nanoparticles are in a solid state at normal temperature and are easy to store, and after being prepared into a solution, the cinnamyl aldehyde solid lipid nanoparticles are long in preservative time and good in dispersion stability.

Description

technical field [0001] The invention relates to the technical field of liposomes, in particular to a cinnamaldehyde solid lipid nanoparticle with high stability and a preparation method thereof. Background technique [0002] Cinnamaldehyde exists in a large amount in essential oils such as cinnamon oil, cinnamon oil, patchouli oil, hyacinth oil and rose oil. Since cinnamaldehyde is volatile, it is easy to volatilize into the air and lead to failure. In order to maintain the long-term antiseptic effect of cinnamaldehyde and reduce the volatility of cinnamaldehyde, liposomes are used to encapsulate cinnamaldehyde, which can play a very good effect. . [0003] Chinese patent CN109056083B discloses "a preparation method of controlled release of cinnamaldehyde essential oil liposome antibacterial bilayer film" using dipalmitoyl phosphatidyl glycerol, distearoyl phosphatidyl choline, cholesterol and cinnamaldehyde essential oils as The cinnamaldehyde heat-sensitive essential oil...

Claims

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Application Information

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IPC IPC(8): A23B7/154A23P10/30
CPCA23B7/154A23P10/30A23V2002/00A23V2200/10A23V2250/21A23V2250/1842A23V2250/192A23V2300/26Y02A50/30
Inventor 胡文忠陈佳佳李尚检萨仁高娃
Owner 珠海科技学院