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Medical chitosan for articular cavity injection and preparation method thereof

A technology of chitosan and joint cavity, which is applied in the field of medical chitosan injected into the joint cavity and its preparation, which can solve the problems of patient irritation and safety impact, reduce alcohol residues, improve use safety, and aseptic Guaranteed high level of effect

Pending Publication Date: 2022-07-15
HANGZHOU SINGCLEAN MEDICAL PROD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chitosan injection will use a large amount of ethanol in the process of alcohol precipitation. If it contains residual ethanol, it may cause irritation to patients and affect the safety during use.

Method used

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  • Medical chitosan for articular cavity injection and preparation method thereof
  • Medical chitosan for articular cavity injection and preparation method thereof
  • Medical chitosan for articular cavity injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] 1) Preparation of carboxymethyl chitin: After crushing the massive chitin in a pulverizer, sieve through a 50-mesh sieve; weigh 200 g of chitin after sieving and dissolve it in 200 mL of isopropanol, stir, expand and swell, and stir for 2.0-2.5 h, 50% sodium hydroxide solution (weigh 400±0.2g sodium hydroxide, then dissolve sodium hydroxide in 400mL water for injection) is cooled to below 15°C in an ice-water bath and slowly added to the above-mentioned chitin solution; Remove the ice water bath, slowly add the chloroacetic acid solution (accurately weigh chloroacetic acid 440 and dissolve it in 1000 mL of isopropanol) into the above alkalized chitin solution, continue to stir for 3.5-4.0 h after the addition, and let stand for 10 h after stirring. above;

[0043] Alcohol precipitation: the carboxymethyl chitin after standing for stratification, pouring off the supernatant, and then transferring it to a 2# sand core funnel for vacuum filtration. After suction filtration...

Embodiment 2

[0050] 1) Preparation of carboxymethyl chitin: After crushing the massive chitin in a pulverizer, sieve through a 50-mesh sieve; weigh 200 g of chitin after sieving and dissolve it in 200 mL of isopropanol, stir, expand and swell, and stir for 2.0-2.5 h, 50% sodium hydroxide solution (weigh 400±0.2g sodium hydroxide, then dissolve sodium hydroxide in 400mL water for injection) is cooled to below 15°C in an ice-water bath and slowly added to the above-mentioned chitin solution; Remove the ice water bath, slowly add the chloroacetic acid solution (accurately weigh chloroacetic acid 440 and dissolve it in 1000 mL of isopropanol) into the above alkalized chitin solution, continue to stir for 3.5-4.0 h after the addition, and let stand for 10 h after stirring. above;

[0051] Alcohol precipitation: the carboxymethyl chitin after standing for stratification, pouring off the supernatant, and then transferring it to a 2# sand core funnel for vacuum filtration. After suction filtration...

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Abstract

The invention provides medical chitosan for articular cavity injection and a preparation method thereof, the material is prepared from carboxymethyl chitin and equilibrium liquid, the appearance is colorless and transparent viscous liquid, the medical chitosan is directly filled into an injector after being prepared, and then terminal sterilization is performed to obtain the medical chitosan. The terminal sterilization adopts terminal high-temperature moist heat sterilization, the equilibrium liquid is prepared from sodium chloride, sodium dihydrogen phosphate and disodium hydrogen phosphate according to a certain proportion, the main component of the material is polyglucosamine, and the material has viscoelasticity and slow absorbability and can be used for intra-articular injection; as a lubricant in a bone joint, the lubricant is used for lubricating the joint, protecting articular cartilage and assisting in treatment of osteoarthrosis.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a medical chitosan for articular cavity injection and a preparation method thereof, and is expected to be applied to orthopedic fields such as osteoarthritis and cartilage injury. Background technique [0002] At present, the clinical treatment of osteoarthritis includes non-drug conservative treatment, drug treatment and surgical treatment. It is necessary to choose an individualized treatment plan according to the disease stage and systemic condition of the patient. Intra-articular injection of drugs or biological agents has the advantages of simple operation, high local bioavailability, and few systemic adverse reactions. Preparations currently used for intra-articular injection include: hyaluronic acid, glucocorticoids, platelet-rich plasma, medical chitosan, etc. Various intra-articular injections have their own characteristics: Glucocorticoids have the chara...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/722A61K9/08A61L2/04A61P19/02C08B37/08
CPCC08B37/003A61K31/722A61K9/0019A61K9/08A61P19/02A61L2/0023A61L2202/21
Inventor 王玲爽熊宇飞孙晓青黄伟
Owner HANGZHOU SINGCLEAN MEDICAL PROD
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