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Preparation of polyphenol-iron ion nano material and application of polyphenol-iron ion nano material in oral infection

A technology of nanomaterials and iron ions, which is applied in the direction of medical preparations containing active ingredients, pharmaceutical formulas, and disease resistance to vector transmission, etc. It can solve problems such as lack of stability and impact on healthy tissues, and achieve a simple, fast, and easy preparation process. Oxidase activity, the effect of broad application prospects

Pending Publication Date: 2022-08-05
WENZHOU INST UNIV OF CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in clinical applications, iron oxide nanozymes may bind to some biological tissues due to their lack of stability in physiological media and solutions suitable for therapeutic formulations, which will further adversely affect healthy tissues

Method used

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  • Preparation of polyphenol-iron ion nano material and application of polyphenol-iron ion nano material in oral infection
  • Preparation of polyphenol-iron ion nano material and application of polyphenol-iron ion nano material in oral infection
  • Preparation of polyphenol-iron ion nano material and application of polyphenol-iron ion nano material in oral infection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] (1) adding gallic acid (GA) into the round-bottomed flask, then adding water to dissolve to obtain a molar concentration of 0.1mmol / L polyphenol solution;

[0048] (2) FeCl 3 ·6H 2 O is dissolved in water to obtain a molar concentration of 10 mmol / L iron ion solution;

[0049] (3) 40 μL of the iron ion solution prepared in step (2) was added dropwise to 3.96 mL of the polyphenol solution prepared in step (1) at a rate of one drop per 10s, so that the polyphenols in the polyphenol solution were reduced. The molar ratio to the iron ion in the iron ion solution is 99:100, stop the dropwise addition, and then stir at room temperature 25 ° C for 30 min, and after stirring evenly, the polyphenol-iron ion nanomaterial (GA-Fe 3+ ).

[0050] The GA-Fe prepared in Example 1 3+ Add dropwise to the silicon wafer, let stand for 24h and vacuum dry, and carry out SEM test. The scanning electron microscope picture is shown in figure 1 ,Depend on figure 1 It can be seen that the r...

Embodiment 2

[0053] The same as in Example 1, the difference is only that the gallic acid (GA) is replaced in an equal amount (the amount of the substance is equal) with tannic acid (TA) to obtain a polyphenol-iron ion nanomaterial (TA-Fe 3+ ), the shape is oval, the particle size test results are shown in the figure Figure 4 , it can be seen that the particle size is 127.9 nm.

Embodiment 3

[0055] The same as Example 1, the difference is only that the gallic acid (GA) is replaced by an equal amount (the amount of the substance is equal) with epigallocatechin gallate (EGCG) to obtain a polyphenol-iron ion nanomaterial (EGCG-Fe 3+ ), the shape is oval, the particle size test results are shown in the figure Figure 5 , it can be seen that the particle size is 94.26 nm.

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Abstract

The invention discloses preparation of a polyphenol-iron ion nano material and application of the polyphenol-iron ion nano material in oral infection, and belongs to the technical field of biomedical materials. The polyphenol-iron ion nano material takes plant polyphenol and metal iron ions as raw materials, and the preparation method comprises the following steps: dissolving the plant polyphenol in water to obtain a polyphenol solution; dissolving ferric chloride in water to obtain an iron ion solution; and dropwise adding the iron ion solution into the polyphenol solution, and uniformly stirring to obtain the polyphenol-iron ion nano material. The prepared polyphenol-iron ion nano material can efficiently kill cariogenic bacteria, the raw materials of the preparation method are easy to obtain, the preparation process is simple and rapid, and the prepared nano particles are uniform and stable.

Description

technical field [0001] The invention relates to the preparation of a polyphenol-iron ion nanomaterial and its application in oral infection, and belongs to the technical field of biomedical materials. Background technique [0002] Biofilms are structures formed by bacteria within the mucus (mucopolysaccharides) they secrete. The biofilm that surrounds the bacteria provides protection for the bacteria, making them difficult to remove. Many diseases in humans are caused by biofilms, such as dental caries (ie, tooth decay). Dental caries has posed a major threat to public health and is a typical biofilm-type disease. In cariogenic biofilms, the local acidic pH environment created by microorganisms promotes the growth of cariogenic bacteria and the acid dissolution of tooth enamel. The membrane is difficult to remove and can demineralize the enamel apatite, leading to the development of dental caries. Traditional antibacterial agents such as chlorhexidine have limited treatme...

Claims

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Application Information

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IPC IPC(8): A61K33/26A61K31/192A61K31/353A61K31/7024A61K9/14A61P1/02A61P31/04
CPCA61K33/26A61K31/7024A61K31/353A61K31/192A61K9/14A61P1/02A61P31/04Y02A50/30
Inventor 刘勇王娅然胡荣党李圆凤詹益周伍凡
Owner WENZHOU INST UNIV OF CHINESE ACAD OF SCI
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