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Vitamin B6 + probiotic mixture and application thereof in preparation of medicine for relieving stress-related secondary injury and aseptic inflammation

A technology of aseptic inflammation and vitamins, applied in the field of biomedicine, can solve the problems of poor compliance, side effects, exacerbation, etc., and achieve the effect of high specificity, reducing inflammation level, and reducing activation level

Pending Publication Date: 2022-08-05
THE THIRD XIANGYA HOSPITAL OF CENT SOUTH UNIV
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AI Technical Summary

Problems solved by technology

However, prevention of secondary diseases in chronically stressed individuals remains clinically challenging due to poor adherence to non-pharmaceutical inventions and side effects of pharmacological approaches
Furthermore, this challenge is further exacerbated by the fact that these strategies are ineffective against stress-induced activation of the HPA axis and its downstream innate inflammation and glucocorticoids

Method used

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  • Vitamin B6 + probiotic mixture and application thereof in preparation of medicine for relieving stress-related secondary injury and aseptic inflammation
  • Vitamin B6 + probiotic mixture and application thereof in preparation of medicine for relieving stress-related secondary injury and aseptic inflammation
  • Vitamin B6 + probiotic mixture and application thereof in preparation of medicine for relieving stress-related secondary injury and aseptic inflammation

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Embodiment

[0027] 8w male SD rats were randomly divided into control group, chronic stress group, flora transplantation group, sham transplantation group, chronic stress+placebo group, and chronic stress+vitamin B6+probiotics group.

[0028] Chronic Restraint Stress: Chronically stressed rats received restraint stress in clear tubes from 6:00 pm to 9:00 am the next day, without food and water, for 4 weeks. The stress-free control group received only the injection treatment, cage change, and behavioral testing, without any other restraint procedures.

[0029] Gut microbiota transplantation: To avoid the effects of gastric acid and oxygen exposure on the transplanted gut microbiota, we modified the reported gut microbiota transplantation and in our study directly transplanted the gut microbiota to the cecum via the anus . Procedures included: First, donor rats were euthanized with 8% sevoflurane after 1, 2, 3, or 4 weeks of stress, and their caecal contents were rapidly collected into air...

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Abstract

The invention provides a vitamin B6 + probiotic mixture and application thereof in preparation of drugs for relieving stress-related secondary injuries and aseptic inflammations, based on microbiomics and metabonomics studies performed after a rat is subjected to chronic stress treatment in a basic experiment, probiotics and vitamin B6 are applied to a chronic stress rat model, and the stress-related secondary injuries and aseptic inflammations are relieved. Through detection of brain injury related parameters, peripheral stress and inflammation levels and intestinal flora omics and supplement of probiotics and vitamin B6, the inflammation level of hippocampus can be relieved, the microglial cell activation level can be reduced, hippocampus neuron neogenesis can be improved, peripheral blood glucose corticoid and inflammation levels can be reduced, and intestinal flora disorder can be corrected; it is indicated that supplement of probiotics and vitamin B6 has a positive effect on prevention and treatment of stress-related secondary injuries and has a good application prospect in preparation of drugs for relieving stress-related secondary injuries and aseptic inflammations.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to a vitamin B6+ probiotic mixture and its application in preparing a drug for reducing stress-related secondary injury and aseptic inflammation. Background technique [0002] Chronic stress-related mental illness, neurodegenerative disease, and brain aging constitute one of the health epidemics. At present, the effect of preventing chronic stress-related diseases in individuals is still not optimistic. It is well known that stress can activate the hypothalamic-pituitary-adrenal (HPA) axis and the sympathetic nervous system (SNS), thereby impairing people's health. However, preventing chronic stress-induced diseases with current management strategies remains clinically challenging due to the complexity of stress response signaling to body and physiological functions. [0003] Current clinical stress management strategies include distraction, physical activity, relaxation, socialization a...

Claims

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Application Information

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IPC IPC(8): A61K35/741A61K31/4415A61P43/00A61P29/00
CPCA61K31/4415A61K35/741A61P43/00A61P29/00A61K2300/00
Inventor 童建斌欧阳文卿文祥陈惠敏
Owner THE THIRD XIANGYA HOSPITAL OF CENT SOUTH UNIV
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