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Magnesium-zinc alloy biliary stent and preparation method thereof

An alloy, magnesium-zinc technology, applied in the field of magnesium-zinc alloy biliary stent and preparation, can solve problems such as low strength and limited support force, and achieve the effects of good corrosion resistance, good forming ability, and good radial support force

Pending Publication Date: 2022-08-05
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantages of the above-mentioned degradable and absorbable magnesium alloy stents are low strength and limited support force

Method used

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  • Magnesium-zinc alloy biliary stent and preparation method thereof
  • Magnesium-zinc alloy biliary stent and preparation method thereof
  • Magnesium-zinc alloy biliary stent and preparation method thereof

Examples

Experimental program
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Effect test

preparation example Construction

[0032] like Figure 1-Figure 2 As shown, the present embodiment provides a method for preparing a magnesium-zinc alloy biliary stent, comprising the following steps:

[0033] S1: Select magnesium-zinc alloy casting billet, wherein the mass fraction of Zn is 1.8%-2.2%, and the balance is Mg;

[0034] S2: heating the magnesium-zinc alloy casting billet to 330°C-350°C, and performing single-pass extrusion at 330°C-350°C, with an extrusion ratio of 70-100, to obtain an extruded pipe;

[0035] S3: The extruded pipe is subjected to multiple passes of room temperature rolling deformation, wherein the deformation amount of a single pass is 5%-10%, and annealing is carried out at 200 ℃-250 ℃ after each pass of rolling, so as to obtain a human bile duct implantation. size of rolled pipe;

[0036] S4: hot-drawing the rolled pipe at 230°C-260°C to obtain a magnesium-zinc alloy pipe with a smooth surface and a uniform microstructure;

[0037] S5: The spiral groove 2 is processed on the ...

Embodiment 1

[0058] The magnesium-zinc alloy pipe with Zn content of 2% is selected, the outer diameter of the magnesium-zinc alloy pipe is less than 2.6mm, and the wall thickness is less than 0.18mm. The above-mentioned magnesium-zinc pipe is laser-cut to form a helical support portion 4 with a helical structure and annular support portions 3 at both ends, wherein the width of the helical groove is 0.2 mm and the pitch is 1.5 mm. After the biliary stent was implanted into the pig common bile duct with the cooperation of the endoscopic retrograde cholangiopancreatography (ERCP) system, the stent remained in the bile duct for 30 days, and the biliary stent was completely discharged after 40 days. Biosafety is good.

Embodiment 2

[0060] Select a magnesium-zinc alloy casting billet with a Zn content of 2%; heat the billet to a set temperature of 330 °C, and perform single-pass extrusion at 330 °C, with an extrusion ratio of 80; and then pass through multiple passes at 20 °C 10% deformation, annealed at 230°C for 5 minutes after each single pass, and the obtained rolled tube was hot drawn at 250°C to obtain a final tube with an outer diameter of 2.5mm and a wall thickness of 0.15mm . The room temperature yield strength of the magnesium-zinc alloy pipe is 175MPa, and the tensile strength is 238MPa. The biliary stent was cut out of the above magnesium-zinc alloy tube by laser, and the biliary stent was implanted into the pig common bile duct with the cooperation of the endoscopic retrograde cholangiopancreatography (ERCP) system, and the stent was maintained in the bile duct for 30 days. Completely drained. Biosafety is good.

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Abstract

The invention discloses a magnesium-zinc alloy biliary stent and a preparation method, and relates to the technical field of biliary stents.The preparation method comprises the following steps that S1, a magnesium-zinc alloy casting blank is selected, the mass fraction of Zn is 1.8%-2.2%, and the balance is Mg; s2, the magnesium-zinc alloy casting blank is subjected to single-pass extrusion at the temperature of 330-350 DEG C, and an extruded pipe is obtained; s3, the extruded pipe is subjected to multi-pass room temperature rolling deformation, and a rolled pipe is obtained; s4, the rolled pipe is subjected to hot drawing at the temperature of 230-260 DEG C, and a magnesium-zinc alloy pipe is obtained; s5, a spiral groove is machined in the peripheral face of the magnesium-zinc alloy pipe, and the magnesium-zinc alloy pipe is divided into annular supporting parts at the two ends and a spiral supporting part in the middle; and S6, the magnesium-zinc alloy pipe is subjected to electrolytic polishing, burrs are removed, and the surface is activated. The magnesium-zinc alloy biliary stent is high in dimensional precision, good in mechanical property, high in flexibility, good in radial supporting force and long in degradation service cycle.

Description

technical field [0001] The invention relates to the technical field of biliary stents, in particular to a magnesium-zinc alloy biliary stent and a preparation method. Background technique [0002] Magnesium and its alloys are known as green engineering materials in the 21st century. In addition, magnesium can also spontaneously corrode and degrade in the human environment, and the degradation products can be absorbed by the human body. It has excellent biocompatibility and is the most representative medical degradable metal material. [0003] At present, there is a huge clinical demand for biliary stents, while the research and development of degradable magnesium metal biliary stents is relatively rare. Good degradation properties to avoid fracture failure during expected service. The composition of magnesium-zinc alloy is an inherent element of the human body, and its excellent biocompatibility and safety are ideal for implanted devices in vivo. However, compared with ra...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B23P15/00A61F2/88C22C23/04C22F1/06C21D8/10C25F3/18
CPCB23P15/00A61F2/88C22C23/04C22F1/06C21D8/10C25F3/18
Inventor 彭宏州昝睿康鑫宝王文辉崔宏王垒沈鸣昱张小农
Owner SHANGHAI JIAO TONG UNIV
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