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Dialysis concentrate and preparation and quality detection method thereof

A concentrate and measuring cup technology, which is applied in the field of dialysis concentrate and its preparation and quality inspection, can solve the problems affecting the quality of hemodialysis treatment and the quality of life of dialysis patients, and achieve the effects of stable content, simple operation, and low impact of inspection

Pending Publication Date: 2022-08-09
HUAYU WU XI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] A large number of clinical evidences have shown that the quality of dialysate directly affects the quality of hemodialysis treatment, thereby affecting the quality of life of dialysis patients

Method used

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  • Dialysis concentrate and preparation and quality detection method thereof
  • Dialysis concentrate and preparation and quality detection method thereof
  • Dialysis concentrate and preparation and quality detection method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] A dialysis concentrate comprising lactate, osmotic agent, said lactate comprising sodium chloride, calcium chloride, magnesium chloride; said osmotic agent comprising glucose, icodextrin, cyclodextrin, modified starch, Polyol, fructose, protein, amino sugar, buffer is sodium lactate, regulator is tromethamine;

[0034] Preparation method The dialysate is formed by mixing the following components:

[0035]

[0036]

[0037] Specific steps are as follows:

[0038] S1. Take the mixing measuring cup and mixing container, first use pure water to re-clean the inner and outer walls of the measuring cup and mixing container, and then sterilize by high temperature evaporation, high pressure sterilization, and finally ultraviolet sterilization;

[0039] S2, pour sodium chloride, calcium chloride, magnesium chloride, sodium lactate, and glucose into the measuring cup processed in step S1, respectively, and add pure water for dialysis, stir and melt, and then introduce the r...

Embodiment 2

[0045] Potassium chloride can also be added for potassium-deficient patients, including a dialysis concentrate, including lactate, and an osmotic agent, the lactate including sodium chloride, calcium chloride, magnesium chloride; the osmotic agent including glucose, Icodextrin, cyclodextrin, modified starch, polyol, fructose, protein, amino sugar, the buffer is sodium lactate, and the regulator is tromethamine;

[0046] Preparation method The dialysate is formed by mixing the following components:

[0047]

[0048] Specific steps are as follows:

[0049] S1. Take the mixing measuring cup and mixing container, first use pure water to re-clean the inner and outer walls of the measuring cup and mixing container, and then pass through high temperature evaporation disinfection, high pressure sterilization, and finally ultraviolet sterilization;

[0050] S2, pour sodium chloride, calcium chloride, magnesium chloride, sodium lactate, and glucose into the measuring cup processed i...

Embodiment 3

[0056] A dialysis concentrate comprising lactate, osmotic agent, said lactate comprising sodium chloride, calcium chloride, magnesium chloride; said osmotic agent comprising glucose, icodextrin, cyclodextrin, modified starch, Polyol, fructose, protein, amino sugar, buffer is sodium lactate, regulator is tromethamine;

[0057] Preparation method The dialysate is formed by mixing the following components:

[0058]

[0059] Specific steps are as follows:

[0060]S1. Take the mixing measuring cup and mixing container, first use pure water to re-clean the inner and outer walls of the measuring cup and mixing container, and then pass through high temperature evaporation disinfection, high pressure sterilization, and finally ultraviolet sterilization;

[0061] S2, pour sodium chloride, calcium chloride, magnesium chloride, sodium lactate, and glucose into the measuring cup processed in step S1, respectively, and add pure water for dialysis, stir and melt, and then introduce the r...

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Abstract

The invention provides a dialysis concentrate and a preparation and quality detection method thereof, and belongs to the technical field of dialyzates, the dialysis concentrate comprises lactate, a penetrant and a buffer agent; the lactate comprises sodium chloride, calcium chloride and magnesium chloride; the penetrant comprises glucose, icodextrin, cyclodextrin, modified starch, polyol, fructose, protein and amino sugar; the penetrant further comprises a regulator; the buffering agent is at least one of sodium lactate, bicarbonate, pyruvate and citrate. The dialysis concentrate is formed by mixing the lactate, the penetrant and the buffering agent, the sodium chloride, the calcium chloride and the magnesium chloride are the ion content of the dialysate, the added glucose, icodextrin and cyclodextrin penetrant can contribute to the permeation of the dialysate, and the penetrant hardly interferes with the sodium lactate, so that the dialysis concentrate has the advantages that the dialysis concentrate is safe and reliable. And the content accuracy of the mixed sodium lactate is ensured.

Description

technical field [0001] The invention relates to the technical field of dialysis concentrates, in particular to a dialysis concentrate and a method for its preparation and quality detection. Background technique [0002] At present, the dialysis methods for kidney disease are mostly peritoneal dialysis and hemodialysis. Peritoneal dialysis uses the peritoneum as a semi-permeable membrane, and exchanges water and solutes between the peritoneal capillaries and the dialysate. Moving to the low side, water molecules move from the side with low osmotic concentration to the side with high osmotic concentration. Through the solute concentration gradient difference, the uremic substances in the blood can be removed from the dialysate, and the electrolyte and acid-base balance can be maintained, replacing part of the function of the kidney. It needs to be designed according to human blood components and meet the treatment requirements. [0003] A large amount of clinical evidence ha...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/14A61K47/26A61K47/36A61K47/40A61K47/10A61K47/42A61P7/08G01N30/02G01N30/32G01N30/54A61K31/19A61K33/06
CPCA61K31/19A61K33/14A61K33/06A61K47/26A61K47/36A61K47/40A61K47/10A61K47/42A61P7/08G01N30/02G01N30/32G01N30/54G01N2030/324A61K2300/00
Inventor 林裕朗郭寅生殷音
Owner HUAYU WU XI PHARMA
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