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Absorbable composite material and preparation method thereof

A technology for absorbing composite materials and manufacturing methods, which is applied in the field of absorbable composite materials and its preparation, can solve the problems of needing improvement in osteogenesis, fast degradation speed, and limited scope of application, so as to facilitate bone tissue repair, realize large-scale production, The effect of high overall performance

Pending Publication Date: 2022-08-09
CHANGCHUN SINOBIOMATERIALS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in absorbable products, there is a problem of insufficient mechanical properties of materials obtained by combining organic matter or organic matter with inorganic matter, and the scope of application is relatively limited.
Absorbable metal implants that avoid secondary surgery can absorb metal materials themselves. Although the strength is high, there are many data showing that its degradation speed is fast, and many problems are likely to be caused during the rapid degradation process. For example, the metal ions produced during the degradation process are easy to Local inflammation or ion poisoning occurs, such as the bone repair process in patients with osteoporosis or the degradation products are likely to have some negative effects due to the large amount of implantation, and the osteogenesis situation needs to be improved

Method used

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  • Absorbable composite material and preparation method thereof
  • Absorbable composite material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] a. Preset absorbable magnesium-zinc alloy wire with a diameter of about 0.1mm into the mold, and arrange it in multiple layers, with a gap of about 1.0mm between each layer, of which the absorbable magnesium-zinc alloy wire accounts for the total volume of the composite material 5%.

[0054] b. Mix 1 part of bioceramic hydroxyapatite and 99 parts of polyglycolide, set the temperature of each section of the extruder equipment in the range of 60°C to 230°C, and carry out melting, mixing, shearing, dispersing and pulling. Elongate and cool the pellets to obtain uniformly dispersed pellets.

[0055] c. Filling with bioceramic hydroxyapatite powder and absorbable polyester material in the interval of absorbable magnesium-zinc alloy wire of each layer. The temperature of the hydraulic press was raised to 220°C, the mold with the wire was placed on the equipment, and the pellets prepared in b were placed on the mold. It is fully preheated, until it is completely melted, pres...

Embodiment 2

[0058] a. Preset absorbable magnesium-iron alloy wires with a diameter of about 1mm into the mold, interweave or arrange them in parallel, in one or more layers, with a gap of about 1.5mm between each layer, in which the absorbable magnesium-iron alloy wires account for the composite 18% of the total volume of the material. After the die is firmly connected to the extruder die, the die is preheated.

[0059] b. Mix the ratio of 15 parts of bioceramic tricalcium phosphate and 85 parts of polylactic acid, set the temperature of each section of the extruder equipment in the range of 60 ° C ~ 230 ° C, and perform melt extrusion, and the molten composite material passes through the die. Flow into a mold with wire to obtain a uniformly dispersed composite material. The obtained composite material is cooled and shaped into a rod, and after sufficient cooling, it is subjected to subsequent processing, and the final material is subjected to a mechanical test, the bending strength can ...

Embodiment 3

[0061] Preset absorbable magnesium-zirconium alloy wires with diameters less than 2mm in different thicknesses into the mold and arrange them in parallel with a gap of about 1.5mm between the layers, of which the absorbable magnesium-zirconium alloy wires account for 32% of the total volume of the composite material. %. Put the used mold in the injection molding machine for preheating. The blend of 90 parts of polylactic acid, 5 parts of polyglycolide and 5 parts of hydroxyapatite powder is initially mixed and dispersed, and then granulated, and the temperature of each section of the extruder is controlled at 60-230°C. The pellets are then injected, and the temperature of each section of the injection molding machine is controlled at 190-230°C. The molten material is filled into the mold by injection molding. The composite material is obtained by cooling and setting. The obtained composite material can be stretched or extruded at a heating and non-melting temperature to enh...

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Abstract

The invention belongs to the technical field of composite materials, and particularly relates to an absorbable composite material and a preparation method thereof. The material is formed by compounding an absorbable metal wire and an absorbable polyester and biological ceramic mixture, the method comprises the following steps: presetting absorbable metal wires in a mold, arranging the absorbable metal wires into one layer or multiple layers, and filling with biological ceramics and absorbable polyester materials; the absorbable composite material can be used as a bone-like material, has high mechanical properties, improves the mechanical properties of a pure absorbable resin and biological ceramic composite material, also improves the characteristics of stress shielding and unfavorable osteogenesis of a pure metal nail, and improves the problems of high degradation speed and easy generation of inflammation due to ion aggregation of the absorbable metal nail; the bone-like components in the material can be more in variety and can contain magnesium, zinc, citric acid and hydroxyapatite, so that the addition amount of the main inorganic component hydroxyapatite of bones with osteoconductivity can be higher in the early stage of mechanics, and bone repair is more facilitated.

Description

technical field [0001] The invention belongs to the technical field of composite materials, and specifically includes an absorbable composite material and a preparation method thereof. Background technique [0002] Non-degradable metal implants used in clinical medical devices for bone repair suffer from stress shielding and secondary removal. Implants made of absorbable polyester or its composite materials with bioceramics have insufficient mechanical properties and limited application scope. . [0003] However, the market demand for orthopaedic bone fixation products is huge. At present, absorbable bone fixation materials are the development trend of implantable medical devices, which can reduce many problems caused by secondary surgery. However, in absorbable products, there is a problem that the mechanical properties of materials obtained by organic matter or the composite of organic matter and inorganic matter are insufficient, and the scope of application is relativel...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/06A61L31/12A61L31/02A61L31/14
CPCA61L31/022A61L31/026A61L31/06A61L31/123A61L31/124A61L31/128A61L31/127A61L31/148
Inventor 丛占福
Owner CHANGCHUN SINOBIOMATERIALS
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