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Process for preparing microspheres of molecular blot polymer in water medium

A technology of molecular imprinting and water-based medium, which is applied in the field of polymer preparation, can solve the problems of unfavorable product popularization and promotion, complex preparation process, and long preparation cycle, and achieve the advantages of favorable promotion and popularization, simple preparation process and short preparation cycle. Effect

Inactive Publication Date: 2004-09-01
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Although the molecularly imprinted polymer prepared by the above method has good recognition performance in aqueous media, the preparation process is complicated and the preparation cycle is long, which is not conducive to the popularization and promotion of the product.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Put 0.2 g of hydroxyethylcellulose HEC and 150 ml of water into the reactor, stir to dissolve and heat to 65°C. 1.276 grams of 2-acrylamido-2-methylpropanesulfonic acid AMPS and 0.107 grams of tyrosine dissolved in 20 ml of water were also added to the reactor. Then 20 milliliters of trimethylolpropane trimethacrylate TRIM, 0.2 grams, azobisisobutyronitrile AIBN and 10 milliliters of toluene are mixed and stirred, and when azobisisobutyronitrile AIBN is dissolved, add in the reactor, After nitrogen gas was introduced for 5 minutes, it was sealed, and the mixture was stirred at a constant temperature of 65° C. and a constant speed of 365 rpm for 8 hours.

[0021] The polymer obtained by the reaction was first washed twice with 100 ml of acetone; then eluted with a mixed solution of 1 mol / l acetic acid and methanol with a molar ratio of 1:3, and 756MC UV-VIS ultraviolet light produced by Shanghai No. 2 Analytical Instrument Factory The spectrophotometer detects the conce...

Embodiment 2

[0023] Put 0.22 g of hydroxyethylcellulose HEC and 150 ml of water into the reactor, stir to dissolve and heat to 75°C. 1.276 grams of 2-acrylamido-2-methylpropanesulfonic acid AMPS and 0.107 grams of tyrosine dissolved in 20 ml of water were also added to the reactor. Then 20 milliliters of trimethylolpropane trimethacrylate TRIM, 0.2 gram of azobisisobutyronitrile AIBN and 10 milliliters of toluene are mixed and stirred, and when azobisisobutyronitrile AIBN dissolves, add in the reactor, pass After entering nitrogen gas for 3 minutes, seal it, and stir at a constant temperature of 75°C and a constant speed of 365rpm for 8 hours to end.

[0024] The polymer obtained by the reaction was first washed twice with 100 ml of acetone; then eluted with a mixed solution of 1 mol / l acetic acid and methanol with a molar ratio of 1:3, and 756MC UV-VIS ultraviolet light produced by Shanghai No. 2 Analytical Instrument Factory The spectrophotometer detects the concentration of tyrosine at...

Embodiment 3

[0026] Put 0.23 g of hydroxyethylcellulose HEC and 150 ml of water into the reactor, stir to dissolve and heat to 70°C. 1.276 grams of 2-acrylamido-2-methylpropanesulfonic acid AMPS and 0.107 grams of tyrosine dissolved in 20 ml of water were also added to the reactor. Then 20 milliliters of trimethylolpropane trimethacrylate TRIM, 0.2 gram of azobisisobutyronitrile AIBN and 10 milliliters of toluene are mixed and stirred, and when azobisisobutyronitrile AIBN dissolves, add in the reactor, pass After entering nitrogen gas for 5 minutes, seal it, keep the temperature at 70°C and the constant speed at 365rpm, and stir for 8 hours to end.

[0027] The polymer obtained by the reaction was first washed twice with 100 ml of acetone; then eluted with a mixed solution of 1 mol / l acetic acid and methanol with a molar ratio of 1:3, and 756MC UV-VIS ultraviolet light produced by Shanghai No. 2 Analytical Instrument Factory The spectrophotometer detects the concentration of tyrosine at 2...

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Abstract

A process for preparing microspheres of molecular blot polymer in water medium includes such steps as dissolving ethoxyl cellulose in water while stirring, putting functional monomer in water, mixing trimethoxyl propane, trimethyl acrylate, trigger and diluent together, mixing said three solutions together, introducing nitrogen gas, sealing, stirring at 65-80 deg.C and 300-400 rpm for 6-10 hr, washing with organic solvent, eluting with diluted acid until temp moleculae are removed, washing with water until it shows neutral, and drying in air.

Description

technical field [0001] The present invention relates to a preparation method of a polymer, more specifically, relates to a preparation method of a polymer with specific recognition performance for template molecules. Background technique [0002] Usually, molecularly imprinted polymers are prepared by bulk polymerization, and the product is in the form of a block, which can be used only after grinding and sieving to obtain particles of the required size. However, grinding will cause some binding groups to be destroyed, thereby reducing the molecular recognition and selectivity of molecularly imprinted polymers MIPs, and the shape of particles obtained by this method is irregular, and the column efficiency when used as a chromatographic stationary phase is also relatively low. Low. In addition, the grinding and sieving process can only obtain some useful products, resulting in huge waste, which leads to increased production and use costs. [0003] ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F2/16C08F20/10
Inventor 成国祥张立永
Owner TIANJIN UNIV
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