Slow-released indapamide capsule and its preparation process

A technology for indapamide and sustained-release capsules, which is applied in the field of indapamide sustained-release capsules and its preparation, can solve the problems of inappropriate popularization and use, large side effects, high price and the like, and achieves shortened processing time, complete absorption, and low cost. low cost effect

Inactive Publication Date: 2004-11-17
TIANJIN GUOYAO BOHAI BIOMEDICAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because the dosage that the patient takes every day is bigger, and the time is longer, thereby the side effect produced by medicine is also relatively bigger; And although the indapamide slow-release tablet that French Servier company produces can reduce the dosage of the patient and improve the bioavailability, but due to the high price of this imported drug, especially for domestic patients who need long-term medication, it is generally unaffordable, so it is not suitable for domestic promotion and use

Method used

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  • Slow-released indapamide capsule and its preparation process
  • Slow-released indapamide capsule and its preparation process

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Based on 1000 indapamide sustained-release capsules, put 105 g of commercially available hollow ball cores between 25 and 30 meshes in a CF300 granulator, and spray 50% sucrose syrup until the hollow ball cores are fully moistened. Wet; mix 1.5g of indapamide through a 100-mesh sieve, 20g of lactose through a 80-mesh sieve, and 20g of starch powder through a 100-mesh sieve, then add it to the above-mentioned granulator and process for 50 minutes to obtain the main ingredient with a smooth surface After the main drug granules are wrapped, continue to spray 50% sucrose syrup, and add 8g of starch to wrap the main drug protective layer, and then dry the wrapped main drug granules in a vacuum oven at 80°C for 3 hours, or Dry in an ordinary electric drying oven at 80°C for 6 hours; dissolve 10g of the acrylic resin sustained-release material EUDRAGIT RS100 with an appropriate amount of 95% ethanol, and add 3g of talcum powder, an auxiliary material for coating, into an approp...

Embodiment 2

[0015] Based on 1000 indapamide sustained-release capsules, put 105 g of commercially available hollow ball cores between 25 and 30 meshes in a CF300 granulator, and spray 50% sucrose syrup until the hollow ball cores are fully moistened. Wet; mix 1.5g of indapamide passing through a 100-mesh sieve, 15g of polyethylene glycol 6000 passing through a 80-mesh sieve, and 13g of pregelatinized starch powder passing through a 100-mesh sieve and add it to the above-mentioned granulator for 50 minutes To obtain the main drug granules with smooth surface, after the main drug granules are wrapped, continue to spray 50% sucrose syrup, and add 5g of starch to wrap the main drug protective layer, and then place the wrapped main drug granules in a vacuum drying at 80°C Dry in an oven for 3 hours, or dry in an ordinary electric drying oven at 80°C for 6 hours; dissolve 8g of polyvinylpyrrolidone with an appropriate amount of 95% ethanol and 12g of hydroxypropyl methylcellulose with 5mL of wat...

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Abstract

An indapamide sustained-release capsule and a preparation method thereof. It is composed of indapamide, slow-release materials and auxiliary materials in a weight ratio of 0.5-3.0:5-20:131-165 to form slow-release pellets with different release degrees. The slow-release materials are acrylic resin, hydroxyl Any one to four of propyl methylcellulose, ethyl cellulose, cellulose acetate phthalate and polyvinylpyrrolidone; the content of indapamide in a single capsule is 0.5-3.0 mg. The preparation method adopts the method of rolling into pellets. The capsule can maintain a balanced and long-lasting effective blood drug concentration within the same dosage and time interval, or reduce the dosage and reduce side effects while maintaining the same drug effect; especially it is a dispersed preparation, which can not only improve the The contact area of ​​the channel can make the drug absorb completely and have high bioavailability, and different combinations of pellets can be used to obtain the ideal drug release rate, and the cost is low. The adopted preparation method has simple process and is easy to operate and control.

Description

technical field [0001] The invention relates to the field of medicine and its preparation, in particular to an indapamide sustained-release capsule capable of treating hypertension and a preparation method thereof. Background technique [0002] Hypertension is a common and frequently-occurring disease with a high morbidity rate. If it is not treated properly or not treated in time, it may lead to serious complications and endanger the patient's physical and mental health, and even life-threatening. Indapamide is a new type of sulfonamide diuretic, which is mainly used clinically to treat hypertension. It has diuretic, calcium antagonism, anti-oxidation and elimination of free radicals, and can stimulate the synthesis and inhibition of prostaglandins with free vasodilation Pharmacological effects such as vasoconstriction. Most of the indapamide currently used clinically is a 2.5mg / tablet immediate-release tablet, and patients need to take it 1 to 3 times a day, and the cours...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/52A61K31/4045A61P9/12
Inventor 贾伟薛京杨恩久
Owner TIANJIN GUOYAO BOHAI BIOMEDICAL
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