Chemical synthesizing method for 5-chlorine-2-nitroaniline

A technology for the synthesis of nitroaniline, which is applied in the fields of chemical instruments and methods, preparation of amino compounds, organic chemistry, etc., can solve the problems of high cost and long reaction time, and achieve the advantages of convenient processing, high selectivity and shortened reaction time Effect
CN1182104CInactive Publication Date: 2004-12-29ZHEJIANG UNIV OF TECH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
ZHEJIANG UNIV OF TECH
Publication Date
2004-12-29
Estimated Expiration
Not applicable · inactive patent

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Abstract

The method for synthesizing 5-chloro-2-nitrophenylamine uses 3-chlorophenylamine as initial raw material, and utilizes three-step reaction of formylation, nitration and hydrolysis to synthesize object compound 5-chloro-2-nitrophenylamine, its total yield rate is above 60% and its product purity is above 98%.
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Description

Technical field:

[0001] The present invention relates to a new method for synthesizing 5-chloro-2-nitroaniline. The method uses 3-chloroaniline as a starting material to synthesize target compound 5-chloro-2-nitroaniline through three steps of formylation, nitration and hydrolysis. Background technique:

[0002] 5-Chloro-2-nitroaniline is an important pharmaceutical and pesticide intermediate. The method for the preparation of 5-chloro-2-nitroaniline reported in the literature is to take 3-chloroaniline as starting material, first reacts with acetic anhydride to prepare 3-chloroacetanilide, then in the mixed solvent of acetic acid and acetic anhydride, use Nitration with fuming nitric acid produced 5-chloro-2-nitroacetanilide, and finally reflux reaction in sodium methoxide / methanol solution for 24 hours to synthesize the target compound 5-chloro-2-nitroacetaniline (GB2018766). This method uses acetic anhydride as a protecting group, and the cost is relatively high; when 3...

Claims

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