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United slow release agent for preventing and treating piglet and rabbit coccidiosis and dysentery disease and its preparing method

A technology of rabbit coccidiosis and sustained-release preparations, which is applied in the direction of drug combination, active ingredients of heterocyclic compounds, powder delivery, etc. It can solve the problems of low drug inclusion rate and unstable effect, and achieve convenient use and less dosage , long-term effect of effective control

Inactive Publication Date: 2005-12-21
ZHEJIANG ACADEMY OF AGRICULTURE SCIENCES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the process of developing the joint sustained-release agent, the difficulty encountered is that the drug inclusion rate is low, only about 65%, and the effect of the product is unstable in the application test.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

specific Embodiment approach

[0017] Diclazuril is produced by Zhejiang Shenghua Biok Bio Co., Ltd., with a content of 99%; norfloxacin hydrochloride is produced by Zhejiang Hisun Pharmaceutical Co., Ltd., with a content of 99%; ciprofloxacin hydrochloride is produced by Zhejiang Xinchang Kangle Veterinary Medicine Co., Ltd., the content is 99%; N,N-dimethylformamide is produced by Hangzhou Dafang Chemical Reagent Factory; dimethyl sulfoxide is produced by Shanghai Jinshan Chemical Factory, the content is 99%; Produced by Quan Chemical Co., Ltd.

[0018] The joint slow-release agent for preventing and treating coccidiosis and bacillary dysentery of piglets and rabbits is prepared according to the following process steps and conditions:

Embodiment 1

[0020] (1) 50 grams of powdered coccidiocidal agent diclazuril + solvent N, N-dimethylformamide 700 milliliters → water bath heating (50 ℃), until the medicine is completely dissolved into a transparent liquid;

[0021] (2) Grind 2450 grams of powdery β-cyclodextrin + 4900 milliliters of distilled water for 25 minutes to form a paste;

[0022] (3) Pour the diclazuril solution into the pasty β-cyclodextrin, stir for 30 minutes, and continue inclusion at room temperature for 80 minutes;

[0023] (4) 1250 grams of norfloxacin hydrochloride + 1875 milliliters of distilled water → heating in a water bath (50° C.) until the medicine is completely dissolved into a transparent liquid;

[0024] (5) Pour the norfloxacin solution into the above-mentioned diclazuril and β-cyclodextrin inclusion compound, stir for 30 minutes, place at 30-40°C until dry, and after crushing, sieve through 80-90 mesh, that is Form a joint sustained-release powder product;

[0025] (6) Subpackage the combine...

Embodiment 2

[0027] (1) 50 grams of powdered coccidiocidal agent diclazuril + solvent N, N-dimethylformamide 800 milliliters → water bath heating (50 ℃), until the medicine is completely dissolved into a transparent liquid;

[0028] (2) Grind 2450 grams of powdered β-cyclodextrin + 7350 ml of distilled water for 25 minutes to form a paste;

[0029] (3) Pour the diclazuril solution into the pasty β-cyclodextrin, stir for 50 minutes, and continue inclusion at room temperature for 120 minutes;

[0030] (4) 1250 grams of ciprofloxacin hydrochloride + 3125 milliliters of distilled water → heating in a water bath (50° C.) until the medicine is completely dissolved into a transparent liquid;

[0031] (5) Pour the ciprofloxacin solution into the above-mentioned inclusion complex of diclazuril and β-cyclodextrin, stir for 60 minutes, place at 30-40°C until dry, and after crushing, sieve through 80-90 mesh, Serve joint sustained-release powder products;

[0032] (6) The same as step 6 of Example 1...

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Abstract

The invention discloses a combined slow-release agent for preventing and treating coccidiosis and bacillary dysentery in piglets and rabbits and a preparation method thereof. The method significantly improves the inclusion rate of the drug in β-cyclodextrin, thereby successfully preparing a high-efficiency, A new pharmaceutical dosage form of a combination slow-release agent for the stable prevention and treatment of coccidiosis and bacillary dysentery in piglets and rabbits. The gist of its technical scheme is, with diclazuril and norfloxacin or ciprofloxacin and β-cyclodextrin as main raw materials, carry out reasonable optimization ratio and supplement with certain technological conditions, first diclazuril is mixed in solvent Dissolve in medium, grind β-cyclodextrin with distilled water to form a paste, mix the two together for a period of time, then add norfloxacin solution or ciprofloxacin solution dissolved in a solvent, stir and include, dry and pulverize , Serve as joint sustained-release powder or formulated as joint sustained-release injection, ready to pack. It is mainly used in the prevention and treatment of coccidiosis and bacillary dysentery in piglets and rabbits.

Description

technical field [0001] The invention relates to a medicine for preventing and treating livestock parasites and bacillary dysentery and a preparation method thereof, in particular to a combined slow-release agent for preventing and treating coccidiosis and bacillary dysentery of piglets and rabbits and a preparation method thereof. Background technique [0002] Piglets and rabbits are often co-infected with coccidiosis and bacterial (such as Escherichia coli, Clostridium welchii, etc.) dysentery, and the infection rate reaches 30-80%, resulting in severe diarrhea (diarrhea) and dehydration. Reach 20~90%, cause great economic loss to aquaculture production. The above-mentioned diseases are widely prevalent in many kinds of animals in various parts of our country, and show an increasing trend year by year. Moreover, the clinical symptoms of these two diseases are similar, and it is generally difficult to distinguish them, and often mixed infections. T...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/14A61K31/53A61P33/14
Inventor 张雪娟方兰勇陈学智袁国华程菊芬冯尚连孙仁寅陈玮尔徐海风
Owner ZHEJIANG ACADEMY OF AGRICULTURE SCIENCES
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