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Process for preparing fatty polyester with variable degradative speed rate and preparation process of product thereof

A technology for the degradation rate of aliphatic polyesters, applied in the field of preparing aliphatic polyesters with different degradation rates or its products, can solve the problems of adverse effects of application, lack of biodegradability, application restrictions, etc., and achieve low addition amount , Significant effect of degradation promotion

Active Publication Date: 2005-12-28
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, copolymers are different from homopolymers in terms of physical and chemical properties, and sometimes even have some adverse effects on applications.
For example, polyethylene glycol (PEG) has good biocompatibility, but it does not have biodegradability. Therefore, it is impossible to completely degrade the aliphatic polyester copolymer containing polyethylene glycol segments. Its application bound to be limited

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] First add 10mL of ε-caprolactone and stannous octoate with a molar ratio of 1:1000 to ε-caprolactone into the 4 polymerization tubes respectively, and then add trifluoroethylene trifluoride with a concentration of 46.8% and a density of 1.13 g / mL respectively. boron ether ether (BF 3 ·OEt 2 ) solution 0, 5, 25, 50 μL, and then placed in an oil bath, under the protection of nitrogen or argon, polymerized at 110°C for 48h. After the polymerization is complete, the polymer is removed from the polymerization tube and placed in air.

[0021] The obtained above-mentioned polyε-caprolactone was sampled after standing for different time, using benzene as a solvent, and measuring the intrinsic viscosity [η] of the polymer at 30° C. with an Ubbelohde viscometer to monitor the molecular weight change of the polymer. The degradation situation of the obtained 4 polymers in air is as follows:

[0022] BF 3 ·OEt 2 Amount added (μL)

Embodiment 2

[0024] Weigh 1.0 g of polyε-caprolactone with an initial intrinsic viscosity [η] of 1.02 in 4 conical flasks with stoppers, add 20 mL of benzene, and after it is completely dissolved, add the concentration of 0, 10, 20, 50 μL of 46.8% boron trifluoride diethyl ether solution with a density of 1.13 g / mL, magnetically stirred and mixed for 24 hours, transferred the above solution to 4 petri dishes, and vacuumed the solvent in a desiccator. Finally, vacuum-dry at 40°C until constant weight.

[0025] The obtained above-mentioned polyε-caprolactone, measured with the test conditions of Example 1, has an intrinsic viscosity [η] of 1.02, 0.85, 0.64, and 0.26, respectively.

Embodiment 3

[0027] Take by weighing tetrahydrofuran as solvent, polystyrene as standard, utilize gel permeation chromatography to measure its weight-average molecular weight Mw to be 42144, the number-average molecular weight Mn is the polyε-caprolactone 1.0g of 12715 in a conical flask with a stopper, Add 20 mL of benzene, and after it is completely dissolved, add 100 μL of boron trifluoride ether solution with a concentration of 46.8% and a density of 1.13 g / mL with a micro-syringe at room temperature, stir magnetically for 24 hours, transfer the solution into a Petri dish, Vacuumize the solvent in a desiccator, and finally vacuum-dry at 40°C until constant weight.

[0028] The obtained above-mentioned polyε-caprolactone was measured by gel permeation chromatography, and its weight-average molecular weight Mw decreased to 8252, and the number-average molecular weight Mn decreased to 2520.

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Abstract

The present invention relates to a method for preparing aliphatic polyesters with different degradation rates or their products, which is characterized in that during the polymerization of aliphatic polyesters or / and during the processing of aliphatic polyesters and their products, the weight percentage of 0.1-6% Lewis acid catalyst. The method of the present invention is simple and easy to implement, the amount of Lewis acid catalyst added is small, the degradation promotion effect is remarkable, and the biocompatibility and biodegradability of the aliphatic polyester itself have no effect. According to actual needs, by adding different amounts catalysts to regulate the degradation rate of aliphatic polyesters to meet different application requirements, especially to expand the application range of aliphatic polyesters with slow degradation rates such as polyε-caprolactone and poly-L-lactide .

Description

1. Technical field [0001] The invention belongs to the technical field of polymer degradation control, and in particular relates to a method for preparing aliphatic polyesters with different degradation rates or products thereof. 2. Background technology [0002] Aliphatic polyesters have good biocompatibility and biodegradability, especially biodegradability, so that they are widely used as biomedical materials and environmentally friendly materials. Representative biodegradable aliphatic polyesters mainly include: polyε-caprolactone (PCL), polydioxanone (PPDO), polyglycolide (PGA), polylactide (PLA), poly Butylene succinate (PBS), polyethylene succinate (PES), polybutylene adipate (PBA), and poly-3-hydroxybutyl [P(3-HB)] Wait. The compositional and structural differences of these aliphatic polyesters endow them with different biodegradable properties and uses. For example, polyglycolide degrades quickly in the body and is suitable for surgical sutures and slow-release d...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B29C47/40C08G63/02
Inventor 王玉忠丁颂东杨科珂汪秀丽周茜
Owner SICHUAN UNIV