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Method for continuously extracting active component from eucommia leaf

A technology of active substances and Eucommia ulmoides leaves, which is applied in the fields of organic chemistry methods, chemical instruments and methods, purification/separation/stabilization of organic compounds, etc., can solve the problems of low utilization rate of raw materials, high processing cost, long production cycle, etc. To achieve the effect of simple method, low cost and low investment

Inactive Publication Date: 2006-02-22
NORTHWEST A & F UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, there is no precedent for extracting Eucommia total glucosides, Eucommia total flavonoids, and Eucommia acidic polysaccharides in this field, and the extraction method for chlorogenic acid components contained in Eucommia is not a method for continuously extracting biologically active substances, and there are still complex processes and production problems. Problems such as long cycle time, low raw material utilization rate, high processing cost and low product yield

Method used

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Experimental program
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Embodiment Construction

[0008] The content of the present invention will be further described below in conjunction with the embodiments.

[0009] 1. Extraction of total glucosides of Eucommia ulmoides and total flavonoids of Eucommia ulmoides

[0010] Water, methanol (concentration is 20% ~ 90%) or ethanol solution is used as extractant, 50kg of Eucommia leaves are soaked in it, vibrating in an ultrasonic oscillator for 2 hours or heating under reflux for 2 hours under the temperature condition of 60 ~ 90°C, Extract 3 times in the same way, concentrate the extract under reduced pressure to 1 / 5 of the volume of the extract, then absorb the concentrate with a macroporous resin (such as X-5, D101, etc.), and wash with water to remove the sugar and pigment, then elute the total glucosides of Eucommia with low concentration (5%-50%) ethanol, and then elute the total flavonoids of Eucommia with high concentration (55%-90%) ethanol, and the eluents are respectively desolvated, Obtain 3.5-3.8 kg of total gl...

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Abstract

The method of extracting biological active substance from eucommia leaf as raw material includes the following processes: 1. using water, methyl alcohol or ethyl alcohol as extracting agent and adopting the procedures of ultrasonic vibration extraction or heating extractino, macroporous resin adsorption and ethyl alcohol elution, etc. to extract eucommia total glyciside and total flavone; 2. using water, methyl alcohol or ethyl alcohol as extracting agent, and adopting the procedures of macroporous resin separation, ethyl acetate extraction and mixed solvent recrystallization to extract chlorogenic acid and eucommia flavone; and 3. using acid aqueous solution as extracting agent, and adopting the procedures of macroporous resin separation, active carbon decolouring and ethyl alcohol precipitation to extract eucommia acid polysaccharide from eucommia leaf residue after other active components are extracted.

Description

technical field [0001] The content of the invention belongs to the technical field of preparation of biochemical articles, and relates to a method for continuously extracting biologically active substances from leaves of Eucommia ulmoides. Background technique [0002] Eucommia ulmoides (Eucommia ulmoides) is a kind of precious medicinal material distributed in the west to the middle of my country. Its bark has always been used as medicine in traditional Chinese medicine. Eucommia ulmoides is rich in eucommia total glycosides, eucommia total flavonoids, chlorogenic acid, eucommia acidic polysaccharide and other active ingredients. Among them, eucommia ulmoides total glycosides are highly concentrated with comprehensive biological activities, which can be used as medicine, health care products, Beverages and curative functional cosmetics, feed antibiotic additives, Eucommia total flavonoids, chlorogenic acid and Eucommia acidic polysaccharides are important raw materials for ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07B63/00A61K36/46C08B37/00C07H1/08C07C67/48C07C69/732C07D311/30
Inventor 马希汉马柏林高锦明张康健王蓝董娟娥尉芹张檀张鞍灵王冬梅
Owner NORTHWEST A & F UNIV