Preparation method of therapy used iodine-125 sealed seed source core
A technology of sealing seed source and source core, which is applied in the direction of medical preparations containing active ingredients, pharmaceutical formulas, radioactive physical shapes, etc., can solve problems such as the generation of a large amount of oxygen, the difficulty of cleaning silver chloride rods, etc., to reduce decomposition, Overcome the impact of compactness and firmness, and reduce the effect of pollution
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Embodiment 1
[0024] (1) Wash 100 silver rods (φ0.5×3mm) with acetone, put them into a reaction bottle, add 1mL 10mg / mL potassium ferricyanide solution, add 4mL 2mol / L sodium chloride aqueous solution, mix well, shake After reacting for 5 hours, a layer of dense silver chloride precipitation was formed on the surface of the silver rod, and the silver rod was taken out, washed three times with deionized water, and dried for later use;
[0025] (2) In the reaction bottle, first add 0.2mL 10mg / mL sodium iodide solution and 0.2mL 20mg / mL sodium bromide solution, then add 100 chlorinated silver rods, add 100mCi radioactive sodium iodide solution, and use Adjust the pH to 10 with 0.01mol / L NaOH solution, mix evenly, shake and react for 9 hours, and then obtain the iodine-125 sealed seed source source core for treatment.
[0026] The utilization rate of iodine-125 is greater than 98%.
[0027] Utilization rate of iodine-125 = (activity of iodine-125 input - activity of iodine-125 in the solutio...
Embodiment 2
[0030] (1) Wash 100 silver rods (φ0.1×3mm) with acetone, put them into a reaction bottle, add 12mL 1mg / mL potassium ferricyanide solution, add 1mL 6mol / L sodium chloride aqueous solution, mix well, shake After reacting for 8 hours, a layer of dense silver chloride precipitation was formed on the surface of the silver rod, and the silver rod was taken out, washed twice with deionized water, and dried for later use;
[0031] (2) In the reaction bottle, first add 0.05mL 100mg / mL sodium iodide solution and 0.05mL 150mg / mL sodium bromide solution, then add 100 chlorinated silver rods, add 200mCi radioactive sodium iodide solution, and use Adjust the pH to 8 with 0.01mol / L NaOH solution, mix evenly, shake and react for 10 hours, and then obtain the iodine-125 sealed seed source source core for treatment.
Embodiment 3
[0033] (1) Wash 100 silver rods (φ0.7×3.5mm) with acetone, put them into a reaction bottle, add 0.0mL of 100mg / mL potassium ferricyanide solution, add 10mL of 0.1mol / L potassium chloride aqueous solution, and mix Evenly, shake and react for 3 hours, forming a layer of dense silver chloride precipitation on the surface of the silver rod, take out the silver rod, wash it twice with deionized water, and dry it for later use;
[0034] (2) In the reaction flask, first add 17mL 1mg / mL potassium iodide solution and 17mL 1mg / mL potassium bromide solution, then add 100 chlorinated silver rods, add 10mCi radioactive sodium iodide solution, and use 0.01mol / L NaOH Adjust the pH of the solution to 9, mix evenly, shake and react for 8 hours, and then obtain the iodine-125 sealed seed source source core for treatment.
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