Method for separating high-purity galanthamine from short-tube lycoris crude extract

Abstract

A process for separating high-purity galantamin from the coarse extract of short-tube lycoris by counter-current chromatography includes such steps as preparing two-phase solvent system from 2,3,044 of paraffin, halohydrocarbon, emtrol, lipoketone, lipoester, ether, buffering liquid of inorganic salt and water, waving, laying aside for layering, dissolving the coarse extract of short-tube lycoris, and separating. Its advantages are high separating capacity and recovery rate, and less solvent consumption.

Description

technical field

[0001] The invention relates to a method for separating galantamine by using countercurrent chromatography technology, in particular to a method for separating high-purity galantamine from crude extract of lycoris by using high-speed countercurrent chromatography technology. Background technique

[0002] Galanthamine is a cholinesterase inhibitor developed in the 1950s. It is an alkaloid extracted from plants such as Amaryllidaceae Lycoris. It has been used for many years to treat myasthenia gravis, muscular dystrophy and sequelae of polio . Galantamine (4a, 5, 9, 10, 11, 12-hexahydro-3-methoxy-11-methyl-6H-benzofuro(3a, 3, 2-ef)-(2) Azepine-6-ol) is a tetracyclic alkaloid whose action is similar to that of physostigmine and neostigmine due to its pharmacological properties, but the therapeutic range of galantamine is wider than that of physostigmine and neostigmine Ming wide, less side effects. Galantamine is also used in the treatmen...