Artificial skin and its prepn and use

An artificial skin and skeleton material technology, applied in the medical field, can solve the problems of not stimulating wound growth and recovery, unable to promote wound healing, unable to complete protection tasks, etc., to eliminate wound exudate, improve water vapor permeability, The effect of solving the problem of wound exudate

Inactive Publication Date: 2002-05-08
SHANDONG LUYE PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, coverings composed only of polymer compounds, such as those made of polyurethane, or polyurethane and ethers, although they have good physical properties, are very strong, water-permeable, Breathable, but only completes the task of protecting the wound surface, and does not have the property of stimulating the growth and recovery of the wound surface; on the other hand, the covering composed only of biopolymers, such as collagen or gelatin and chitosan A mixture of collagen, chitosan, and glycosaminoglycan polymers can stimulate wound growth well, but has poor physical properties: brittle when dry and easily broken when wet , and is quickly decomposed under the action of wound exudate enzymes, unable to complete the protection task
In addition CN1117708 has int...

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Get the milk slurry of 1.5 liters of fluororubber, make it through the filter filter that sieve size is 0.1-0.2mm, the content of solid matter is 360g / l, get the aqueous solution of 2 liters of polysaccharides again (contain 10g Karraginan, 20g alginate altogether acid sodium salt and 30 g methylcellulose). Stir the above liquid evenly to make it fully mixed into one, and filter the obtained mixture again through a filter with a sieve size of 0.1-0.2 mm. Pour the mixture onto a glass plate so that each liter of the mixture is poured at 1.0-1.2m 2 Dry at room temperature to form a completely dry film with a thickness of 0.1mm. Pack the cut film into a sealed package and sterilize it with 2.5Mpag gamma-rays.

Embodiment 2

[0020] Get the serum of 1.0 liters of fluorine rubber, after filtering according to Example 1, get 3 liters of polysaccharide aqueous solution (4 gram carrageenan, 20 gram sodium salt of alginic acid and 30 gram methylcellulose) and iodine glucoside solution 10 milliliters, prepare mixture according to example 1, make film, and make the hole that diameter is 0.1mm according to pore spacing 15mm on film.

Embodiment 3

[0022] Get the emulsion of 0.75 liters of fluororubber, after filtering, the content of solid matter is 360g / l, then get the aqueous solution of 4 liters of polysaccharides (8 gram carrageenan, the sodium salt of 20 gram alginic acid and 30 gram methyl cellulose element) and appropriate amount of Tween-80, according to Example 1 to make a film.

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Abstract

The artificial skin consists of skeleton material and polysaccharide in the weight ratio of 0.1-30:1 as well as some supplementary material. The artificial skin in two kinds, with pores and without pores, may be used in the treatment of burns, wound, frostbite, ulcer and beauty treatment operation. Test shows that using the artificial skin to cover wound area can promote heat of the wound area, eliminate diffusate from the wound, prevent and treat bacteria infection, and reduce the irritation to skin. In addition, it has excellent flexibility and strength and may be uncovered from wound without pain produced.

Description

technical field [0001] The invention relates to the field of medicine, and provides an artificial skin for covering surgical wounds and grade 2 and 3 wounds. Background technique [0002] At present, there are many dressings for treating skin wounds, which are generally divided into three categories: ordinary dressings, biological dressings and synthetic dressings. People generally refer to the film-like dressing as "artificial skin". A better artificial skin is a sheet or film made of polymer compounds or biopolymers. However, coverings composed only of polymer compounds, such as those made of polyurethane, or polyurethane and ethers, although they have good physical properties, are very strong, water-permeable, Breathable, but only completes the task of protecting the wound surface, and does not have the property of stimulating the growth and recovery of the wound surface; on the other hand, the covering composed only of biopolymers, such as collagen or gelatin and chito...

Claims

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Application Information

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IPC IPC(8): A61L27/60
Inventor 刘殿波丛晓东刘珂傅风华岳志勇蒋王林李长林李香玉修姗姗
Owner SHANDONG LUYE PHARMA CO LTD
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