Implanted slow-releasing antiseptic preparation and its preparing method

An antibacterial and sustained-release technology, applied in the field of medicine, can solve the problems of repairing between occluded tissues, inconvenient use, application limitations, etc., and achieve the effects of reducing toxic side effects, reducing usage, and reducing occlusion.

Inactive Publication Date: 2002-06-05
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These systemic medication methods have obvious deficiencies: 1. There are systemic toxicity and side effects; 2. Insufficient local drug concentration; 3. Inconvenient use, etc.
Although these dosage forms solve many shortcomings of systemic application of antibacterial drugs, the antibacterial drug beads must be removed by secondary surgery because the sustained-release auxiliary materials cannot

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Example 1: Preparation of Ciprofloxacin Hydrochloride Sustained Release Microspheres

[0018] 1. Dissolve 1 gram of sodium chloride in 100 milliliters of double distilled water, add 2 grams of carboxymethyl chitosan, and stir for 5 hours at a speed of 100 rpm in a beaker. Then add 2 grams of ciprofloxacin hydrochloride and stir for 2 hours at a speed of 100 rpm to obtain solution A

[0019] 2. Add 30 milliliters of Tween80 to 400 milliliters of liquid paraffin in the reaction flask, and stir at a speed of 500 rpm for 5 minutes to obtain a suspension. Under stirring at 500 rpm, 100 ml of solution A was slowly poured into the above suspension, and stirred at 800 rpm at 30°C for 30 minutes. That is, an emulsified system is obtained.

[0020] 3. Lower the temperature of the emulsification system in the reaction bottle to 5°C to 8°C, drop a solution containing 2 grams of glutaraldehyde into the emulsification system under stirring at a speed of 300 rpm, and continue stirri...

Embodiment 2

[0022] Embodiment Two: Preparation of Gentamicin Sustained-release Microspheres

[0023] 1. Dissolve 2 grams of sodium chloride in 200 milliliters of double-distilled water, add 4 grams of carboxymethyl chitosan, and stir for 5 hours at a speed of 100 rpm in a beaker. Then add 10 grams of gentamicin and stir for 2 hours at a speed of 100 rpm to obtain solution A

[0024] 2. Add 60 milliliters of Tween80 to 800 milliliters of liquid paraffin in the reaction flask, and stir at a speed of 500 rpm for 5 minutes to obtain a suspension. Under stirring at 500 rpm, 200 ml of solution A was slowly poured into the above suspension, and stirred at 800 rpm for 30 minutes at 30°C. That is, an emulsified system is obtained.

[0025] 3. Lower the temperature of the emulsification system in the reaction bottle to 5°C to 8°C, drop the solution containing 4 grams of dialdehyde into the emulsification system under stirring at a speed of 300 rpm, and continue stirring at a speed of 300 rpm for ...

Embodiment 3

[0027] Embodiment three: preparation ofloxacin sustained-release microspheres

[0028] 1. Dissolve 10 grams of sodium chloride in 1000 milliliters of double-distilled water, add 20 grams of carboxymethyl chitosan, and stir for 5 hours at a speed of 100 rpm in a beaker. Then add 20 grams of ofloxacin and stir for 2 hours at a speed of 100 rpm to obtain solution A

[0029] 2. Add 300 ml of Tween80 to 4000 ml of liquid paraffin in the reaction flask, and stir at a speed of 500 rpm for 5 minutes to obtain a suspension. Under stirring at 500 rpm, 1000 ml of solution A was slowly poured into the above suspension, and stirred at 800 rpm for 30 minutes at 30°C. That is, an emulsified system is obtained.

[0030] 3. Lower the temperature of the emulsification system in the reaction bottle to 5°C to 8°C, add a solution containing 20 grams of glutaraldehyde dropwise into the emulsification system under stirring at a speed of 300 rpm, and continue stirring at a speed of 300 rpm 3 hours...

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PUM

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Abstract

The present invention relates to the field of medical technology. By using carboxymerhyl chitosan as slow-releasing assistant and antiseptic as carrier and through emulsification and crosslinking process, a kind of degradable slow-releasing microball is prepared capable of being implanted in operation incision to prevnet post-operational local infection. The slow-releasing preparation of the present invention has the features of degradability and small volume, and avoids the shield to biological repair in oganism.

Description

technical field [0001] The invention relates to the technical field of medicine, and relates to a degradable implanted slow-release dosage form of antibacterial drugs and a preparation method thereof. Background technique [0002] Usually all will use antibacterial medicine for a certain period of time after surgical operation to prevent the infection of patient's surgical incision, especially traumatic operation, implant implantation operation, open wound operation etc. The traditional route of administration of antibacterial drugs is intravenous, oral, intramuscular injection and so on. These systemic medication methods have obvious deficiencies: 1. There are systemic toxicity and side effects; 2. Insufficient local drug concentration; 3. Inconvenient use, etc. Therefore, local implant dosage forms of antibacterial drugs are increasingly concerned by clinicians. At present, implanted slow-release formulations of different antibacterial drugs have been used in clinical pr...

Claims

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Application Information

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IPC IPC(8): A61K9/16A61K9/22A61K31/02A61K31/495A61K31/535A61K31/538A61K47/36
Inventor 侯春林尹承慧顾其胜
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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