In-situ compounding process of synthesizing nano composite chitosan/hydroxyapatite material

Abstract

The invention provides a new method of under the normal temperature and ordinary pressure preparing the shell glycan / the oxhydryl-apatite nano complex materials. The method includes: at first make up the calcium-ion solution and the phosphor-ion solution, then evenly mix the calcium-ion solution with the phosphor-ion solution and add the acetic acid into the mixture to form the solution, then dissolve the shell glycan into this solution, then inject the solution containing the shell glycan into the mould to shape and dry it. Adopting the method of the invention can assure that the particles of the oxhydryl-apetite disperse in the shell glycan base body at the nano measurement (20-100 nm), and the materials made by using the invention's method are transparent and yellowish, and their mechanical property obviously is improved.

Description

technical field [0001] The invention relates to a method for in-situ composite preparation of chitosan / hydroxyapatite nanocomposite material. Background technique [0002] Chitosan (Chitosan, CS) is a natural biodegradable polysaccharide, and its degradation product is weakly alkaline glucosamine, which is non-toxic and harmless to the human body and tissues. In addition to its excellent biocompatibility, it also has natural drug activity, anti-tumor activity, and anti-inflammatory effects. It can induce special cells for damaged organisms and accelerate wound healing. [0003] The chemical structure of hydroxyapatite (Hydroxyapatite, HA) is (Ca 10 (OH) 2 (PO 4 ) 6 ), is the main component of human natural bone (containing 60-70%), has excellent biological activity and guides the growth of bone tissue. HA implants have been shown to induce the growth of surrounding bone tissue and form a strong chemical bond with the host bone. [0004] Adding hyd...

AI Technical Summary

Problems solved by technology

But the final material still exhibits bioceramic properties, i.e. high brittleness and low flexural strength

Moreover, the composite material based on hydroxyapatite degrades very slowly, which does not match the process of fracture healing.

Due to the uneven dispersion of hydroxyapatite and the weak interfacial binding force between hydroxyapatite and chitosan, the composite material prepared by this method is opaque and white in appearance; the mechanical properties are reduced.