In-situ compounding process of synthesizing nano composite chitosan/hydroxyapatite material

A technology of nanocomposite materials and hydroxyapatite, which is applied in the field of in-situ composite preparation of chitosan/hydroxyapatite nanocomposites, can solve the problems of decreased mechanical properties, weak interfacial bonding, and high brittleness, and achieve mechanical Performance improvement and the effect of avoiding the explosion phenomenon

Inactive Publication Date: 2003-01-08
ZHEJIANG UNIV
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Problems solved by technology

But the final material still exhibits bioceramic properties, i.e. high brittleness and low flexural strength
Moreover, the composite material based on hydroxyapatite degrades very slowly, which does not match the process of fracture healing.
D

Method used

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Embodiment Construction

[0013] The present invention is further described below in conjunction with specific examples.

[0014] The method for preparing chitosan / hydroxyapatite nano-composite material by compounding in situ of the present invention comprises the following steps:

[0015] 1) According to hydroxyapatite Ca 10 (OH) 2 (PO 4 ) 6 The amounts of calcium ions and phosphorus ions in the chemical formula are respectively selected from appropriate calcium salts and phosphates to prepare a calcium ion solution with a concentration of 1.6Kg / L and a phosphorus ion solution with a concentration of 0.8Kg / L;

[0016] 2) each get 200ml of calcium ion solution and phosphorus ion solution and mix uniformly in the container, add a certain amount of acetic acid to prepare a solution whose acetic acid concentration (by volume) is 2%;

[0017] 3) chitosan is dissolved in step 2) in the solution gained, is mixed with the chitosan solution that chitosan content (by weight) is 4%;

[0018] 4) Take a small...

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Abstract

The invention provides a new method of under the normal temperature and ordinary pressure preparing the shell glycan/the oxhydryl-apatite nano complex materials. The method includes: at first make up the calcium-ion solution and the phosphor-ion solution, then evenly mix the calcium-ion solution with the phosphor-ion solution and add the acetic acid into the mixture to form the solution, then dissolve the shell glycan into this solution, then inject the solution containing the shell glycan into the mould to shape and dry it. Adopting the method of the invention can assure that the particles of the oxhydryl-apetite disperse in the shell glycan base body at the nano measurement (20-100 nm), and the materials made by using the invention's method are transparent and yellowish, and their mechanical property obviously is improved.

Description

technical field [0001] The invention relates to a method for in-situ composite preparation of chitosan / hydroxyapatite nanocomposite material. Background technique [0002] Chitosan (Chitosan, CS) is a natural biodegradable polysaccharide, and its degradation product is weakly alkaline glucosamine, which is non-toxic and harmless to the human body and tissues. In addition to its excellent biocompatibility, it also has natural drug activity, anti-tumor activity, and anti-inflammatory effects. It can induce special cells for damaged organisms and accelerate wound healing. [0003] The chemical structure of hydroxyapatite (Hydroxyapatite, HA) is (Ca 10 (OH) 2 (PO 4 ) 6 ), is the main component of human natural bone (containing 60-70%), has excellent biological activity and guides the growth of bone tissue. HA implants have been shown to induce the growth of surrounding bone tissue and form a strong chemical bond with the host bone. [0004] Adding hyd...

Claims

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Application Information

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IPC IPC(8): C08K3/32C08K5/49C08L5/08
Inventor 胡巧玲李保强沈家骢
Owner ZHEJIANG UNIV
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