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Method for preparing patent Chinese medicines by biological technology

A biotechnology, Chinese patent medicine technology, applied in biochemical equipment and methods, pharmaceutical formulations, peptide/protein components, etc., can solve the problem of multiple waste residues, waste gas, environmental pollution, damage; in addition, under high temperature and high pressure, it not only destroys or volatilizes and other problems, to achieve the effect of improving drug efficacy, simple method, and significant economic and social significance

Inactive Publication Date: 2003-04-02
郑振标 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the traditional methods of Chinese herbal medicine are soaking, boiling, decocting, boiling, etc. These methods can only extract and concentrate some active ingredients in the raw materials of Chinese medicine, while a large number of beneficial ingredients such as cellulose and volatile oil are damaged to varying degrees; 1. Under high pressure, not only destroy or volatilize part of the active ingredients, but also make the minerals release heavy metals or toxic substances (such as cinnabar) that exceed the human body's allowance; at the same time, the traditional method also produces more waste residue, waste gas, waste water, polluting the environment

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0018] This example is licorice unilaterally.

[0019] Wash and crush 40 kg of licorice to 60 mesh, immerse in lactic acid, and irradiate with 40 UV lamps for 18 hours at the same time, then add 2 liters of compound enzyme reaction solution, stir evenly, and ferment at 40±5°C for 72 hours , control the pH value to 3.5-6.2 during the fermentation process, and finally get the supernatant after sedimentation.

[0020] At the same time, the licorice is decocted according to the traditional method to obtain the filtered decoction.

[0021] Show through analytical result, the extraction rate of the glycyrrhizin of the present invention's method is 2.2 times of the extraction rate of traditional method (by Fujian College of Traditional Chinese Medicine central laboratory test, adopt high-performance liquid chromatography to detect, used instrument is the U.S. tsp high-efficiency Liquid chromatography).

[0022] The compound enzyme reaction solution formula used in this example, by ...

example 2

[0024] This example is 20 kilograms of unilateral Radix Astragali, 1 liter of compound enzyme reaction solution of Example 1, and obtains the supernatant by the method of Example 1. And at the same time decoct the Radix Astragali in water according to the traditional method to obtain a decoction.

[0025] The result shows that the extraction rate of the method of the present invention astragalus polysaccharide is 5 times of the extraction rate of the traditional method (tested by the central laboratory of Fujian College of Traditional Chinese Medicine, adopting colorimetric method to detect, and the instrument used is an ultraviolet / visible spectrophotometer ).

example 3

[0027] This example is a single traditional Chinese medicine prescription, that is, Manshanbai Antitussive (prescription provided by Jianyang Pharmaceutical Factory in Fujian Province). Adopt the enzymolysis method of the present invention of Example 1 for the single-flavor prescription, the amount of crude drug used is 2 kg, and it is made into powder according to the conventional method; according to the traditional decoction method, decoction is obtained, and the amount of crude drug used is 7.7 kg . There is no statistical difference in the antitussive effects of the two, and the amount of medicinal materials used in the traditional method is 3.85 times that of the enzymatic hydrolysis method of the present invention.

[0028] The composite enzyme reaction solution of this example consists of: protoplasmic solution: pear juice 20%, radish juice 10%, green vegetable juice 10%, balsam pear juice 10%; Enzyme promoter is Tween 80 5%; Inorganic salt: ZnSO 4 8%, MgSO 4 2%, KH ...

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Abstract

A process for preparing Chinese patent medicine by biotechnology includes such steps as washing raw materials pulverizing, immersing in lactic acid, radiating by ultraviolet lamp, adding composite enzyme as reaction liquid, fermenting, settling, taking supernatant to obtain liquid medicine, spray drying, and shaping powder, tablet, or capsule. Its advantages are high utilization rate and no generation of wastes.

Description

technical field [0001] The invention belongs to the technical field of enzyme application, and more specifically relates to a method for preparing Chinese patent medicine with a compound enzyme reaction solution. Background technique [0002] Chinese patent medicine is an important part of the motherland's medicine, and it is playing an increasingly important role in protecting people's health. However, the traditional methods of Chinese herbal medicine are soaking, boiling, decocting, boiling, etc. These methods can only extract and concentrate some active ingredients in the raw materials of Chinese medicine, while a large number of beneficial ingredients such as cellulose and volatile oil are damaged to varying degrees; 1. Under high pressure, it not only destroys or volatilizes part of the active ingredients, but also causes the minerals to release heavy metals or toxic substances (such as cinnabar) that exceed the human body's allowance; at the same time, the traditional...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/43C12N9/00
Inventor 林陆山汪奋生
Owner 郑振标
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