Epoxy crosslinking agent and its prepn and application in preparing biodegradable material

A technology of biodegradable materials and cross-linking agents, applied in the preparation of biodegradable materials, the field of preparation of epoxy-based cross-linking agents, can solve the problem of cell toxicity, matching degradation rate, poor cell affinity, etc. problems, to achieve the effect of broadening the range of selection, enhancing mechanical properties, and having no toxic and side effects

Inactive Publication Date: 2003-05-14
JINAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

So so far, there is no material that can meet the basic requirements of tissue engineering scaffold materials, which is mainly manifested in that the degradation rate of the material cannot match the rate of tissue formation; the degradation products of the material are toxic to cells or have adverse effects on tissues. Influence; and the cell affinity on the surface of the material is not good, which affects the adsorption of tissue cells on the surface of the material

Method used

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  • Epoxy crosslinking agent and its prepn and application in preparing biodegradable material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] 13.5g of lactide, 6g of PEG400 and 0.17g of stannous octoate were mixed and stirred, blown with nitrogen, heated to 130°C, and reacted for 6 hours. The crude product was dissolved in chloroform, filtered and dissolved in n-hexane, separated into layers, filtered again, and repeated several times until the liquid was completely transparent, and then dried under vacuum at 55°C for one day. Take 5g of the product, 7.5g of epichlorohydrin and 0.15g of benzyltriethylammonium chloride, add 4g of 50% sodium hydroxide dropwise for 30min under stirring at room temperature, then stir and react at 60°C for 1h; cool, filter with suction, and separate the liquids The organic layer was separated, washed three times with 60 ml of saturated brine, dried over anhydrous magnesium sulfate, and distilled under reduced pressure to obtain a light yellow transparent liquid.

Embodiment 2

[0030] 15g of lactide, 2g of glycerin and 0.15g of stannous octoate were mixed and stirred, nitrogen was blown, the temperature was raised to 130°C, and the reaction was carried out for 6 hours. The crude product was dissolved in chloroform, filtered and dissolved in n-hexane, separated into layers, filtered again, and repeated several times until the liquid was completely transparent, and then dried under vacuum at 55°C for one day. Take 5g of the product, 5g of epichlorohydrin and 0.3g of benzyltriethylammonium chloride, add 3g of 50% sodium hydroxide dropwise for 30min under stirring at room temperature, then stir and react at 60°C for 1h; The organic layer was taken out, washed three times with 60 ml of saturated brine, dried over anhydrous magnesium sulfate, and distilled under reduced pressure to obtain a light yellow transparent liquid.

Embodiment 3

[0032] Mix and stir 12g of lactide, 6g of PEG800 and 0.15g of stannous octoate, blow nitrogen, raise the temperature to 130°C, and react for 6 hours. The crude product was dissolved in chloroform, filtered and dissolved in n-hexane, separated into layers, filtered again, and repeated several times until the liquid was completely transparent, and then dried under vacuum at 55°C for one day. Take 5g of the product, 5g of epichlorohydrin and 0.15g of benzyltriethylammonium chloride, add 4g of 50% sodium hydroxide dropwise for 30min under stirring at room temperature, then stir and react at 60°C for 1h; The organic layer was taken out, washed three times with 60 ml of saturated brine, dried over anhydrous magnesium sulfate, and distilled under reduced pressure to obtain a light yellow transparent liquid.

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Abstract

The present invention relates to an epoxy crosslinking agent and its preparation and application in preparing biodegradable material. The degrading rate and mechanical strength of the biodegradable material are regulated via regulating the molecular weight and amount of the crosslinking agent, so that the degrading rate of the material is matched with the tissue forming rate. The degraded productof the material has no toxicity for cell and no negative effect on tissue, and the cell affinity of the material can promote the adsorption of the cell tissue on the material surface.

Description

technical field [0001] The present invention relates to biodegradable epoxy-based crosslinkers. [0002] The invention also relates to a preparation method of the epoxy-based crosslinking agent. [0003] The invention also relates to the application of the epoxy-based crosslinking agent in the preparation of biodegradable materials. Background technique [0004] Biodegradable materials mainly include biodegradable films and biodegradable scaffold materials. At present, almost all degradable materials such as photodegradable materials studied at home and abroad are made of polyethylene as the matrix material through appropriate modification, and its residual film will cause harm to crops and water resources if it remains in the soil for a long time. If the photosensitive group is introduced into the polymer chain, the pollution problem of degradation products will be better solved, but it is also difficult to popularize due to problems such as processing and production. As...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/24C08L5/00C08L67/00
Inventor 周长忍李立华
Owner JINAN UNIVERSITY
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