High-strength antimicrobial dialdehyde starch crosslinked chitosan membane and preparation method and use thereof

A technology of cross-linked chitosan and dialdehyde starch, which is applied in anticoagulant treatment, transportation and packaging, and packaged food, etc. It can solve the problems of limited application of medical materials, harmfulness to human health, and brittle chitosan film. Achieve the effects of reducing the chance of wound infection, good antibacterial effect, and good flexibility

Inactive Publication Date: 2003-08-06
WUHAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, almost no chitosan film has been commercially produced in commercial applications. One of the most important reasons is that the chitosan film is brittle and has poor mechanical properties. Therefore, it is necessary to improve the mechanical strength of the chitosan film material. become the key to expanding its application
At

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0007] Example 1: The degree of deacetylation is 90.2%, and the viscosity average molecular weight is 5.0×10 5 The chitosan is dissolved in 2% (volume ratio) acetic acid aqueous solution and filtered to obtain a 3% (weight ratio) chitosan solution; the dialdehyde starch with an oxidation degree of 63.5% is dissolved in water at 60℃ and filtered to obtain 5% (weight ratio) dialdehyde starch aqueous solution. The above chitosan solution and dialdehyde starch aqueous solution were fully stirred and mixed at a ratio of 99:1 (weight ratio), centrifuged to defoam, and then a flat glass tube with copper wires at both ends was used to scrape the film on a clean glass plate. Infrared lamp drying. Put the above glass plate into a NaOH solution with a weight percentage of 1-5% to neutralize the residual acid. The film was removed, rinsed thoroughly with running water, and then washed with distilled water to dry to obtain a dialdehyde starch cross-linked chitosan film CSD-1 containing 1% (wei...

Example Embodiment

[0008] Example 2: The mixing ratio of the above chitosan solution and the dialdehyde starch aqueous solution was changed to 97:3 (weight ratio), and the rest was the same as in Example 1, to obtain a dialdehyde starch mixture containing 3% (weight ratio) of dialdehyde starch Combined chitosan film CSD-2.

Example Embodiment

[0009] Example 3: The mixing ratio of the above chitosan solution and the dialdehyde starch aqueous solution was changed to 95:5 (weight ratio), and the rest was the same as in Example 1, to obtain a dialdehyde starch mixture containing 5% (weight ratio) of dialdehyde starch. Combined chitosan film CSD-3.

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PUM

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Abstract

The present invention relates to a high-strength antimirobial dialdehyde starch cross-linked chitosan film, its production method and application. It is made up by using 1-3 wt% of chitosan acetic acid aqueos solution and 2-7 wt% of dialdehyde starch and adopting the processes of fully stirring, mixing, centrifugal defoaming, film-making, washing with acid, washing with water, drying by airing toobtain the invented product dried film. Said chitosan cross-linked film has excellent mechanical strength, flexibility and good antibacterial function, and has no toxic side effect for human body. Said chitosan cross-linked film has good bacteria-inhibiting action, can be used as clinical medical material for reducing infection of wound.

Description

Technical field [0001] The invention relates to a high-strength antibacterial dialdehyde starch cross-linked chitosan film, and a preparation method and application thereof. Background technique [0002] Chitosan (CS) is β-(1→4)-2-amino-D-glucopyranose, which has good biological activity, biocompatibility, biodegradability, antibacterial, hemostatic, and anti-inflammatory And promote biological functions such as wound healing. The linear molecular chain structure of chitosan makes it have excellent film-forming properties, and its film material can be used as artificial skin, hemostatic material and wound dressing material. So far, there has been almost no practical commercial application of chitosan membranes in industrial production. One of the most important reasons is that chitosan membranes are fragile and have poor mechanical properties. Therefore, improving the mechanical strength of chitosan membrane materials Become the key to expand its application. At present, cross-li...

Claims

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Application Information

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IPC IPC(8): A61L33/08C08J3/24C08J5/18C08L3/02C08L5/08
Inventor 杜予民唐汝培樊李红
Owner WUHAN UNIV
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