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Biquanide vanadium complex plaster preparation for curing diabetes and its application

A technology of diabetes drugs and complexes, which is applied in the direction of drug combinations, active ingredients of heavy metal compounds, metabolic diseases, etc., can solve the problems of unable to maintain blood drug concentration, low bioavailability, obvious side effects, etc., and achieve individual differences Small, avoid oral administration, high bioavailability effect

Inactive Publication Date: 2003-12-10
乐益
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Oral drugs have many defects. The drug is affected by the physiological factors of the gastrointestinal tract, and the blood concentration cannot be maintained for a long time after one administration; the influence of the "first-pass effect" of the liver, the influence of the metabolic range, and the bioavailability are not too high. Obvious side effects

Method used

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  • Biquanide vanadium complex plaster preparation for curing diabetes and its application
  • Biquanide vanadium complex plaster preparation for curing diabetes and its application
  • Biquanide vanadium complex plaster preparation for curing diabetes and its application

Examples

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preparation example Construction

[0037] This application provides the preparation of the following patch as an example, but it is not limited to the scope mentioned in the application documents, and can be fully extended to the known film controlled release type, matrix controlled release type, and micro reservoir dissolution controlled release type Or dispersed patches in adhesives, the applicant believes that all patches and their equivalents that contain the main active ingredients pointed out in the present invention and are used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM) and related diseases should belong to protection scope of this patent.

[0038] The skin covering the body surface is only 3mm thick, but it is the largest tissue in the human body. The skin is a barrier between the external environment and the body. Transdermal absorption enhancers refer to substances that can accelerate the speed of drug penetration through the skin without causing serious irritation and damag...

Embodiment 1

[0041] The selected compound is 1,1-dimethylbiguanide vanadium complex, and the vanadium in the complex is coordinated with oxygen; in this pharmaceutical preparation, in addition to the main active ingredient, the transdermal absorption accelerator used is laurocapram (Azone Azone) or menthol; the absorption and penetration aid is ethanol or propanol; the consumption of both is 3.0%; the softening agent is glycerin or polyvinyl alcohol, and the consumption is 5.0%. Except that the main active ingredients are prepared by the US patent method, the rest are all commercially available products.

[0042] The specific weight ratio is:

[0043] 1,1-Dimethylbiguanide vanadium complex 100kg, laurocapram or menthol 3kg, ethanol or propanol 3kg, glycerin or polyvinyl alcohol 5kg, essence 0.5kg.

[0044] Weigh all the materials according to the proportion (the solid is crushed into the required fineness in advance, and dried to the water content ≤ 0.5%), put it in the container and mix ...

Embodiment 2

[0053] The selected compound is 1,1-dimethylbiguanide vanadium complex, and the vanadium in the complex is coordinated with oxygen; in the pharmaceutical preparation, the transdermal absorption accelerator used in addition to the main active ingredient is laurocapram; Absorption and penetration aids are ethanol or propylene glycol; emollients are glycerin or polyvinyl alcohol.

[0054] The specific weight ratio is:

[0055] 1,1-Dimethylbiguanide vanadium complex 100kg, laurocapram 5kg, ethanol or propylene glycol 2.5kg, glycerin or polyvinyl alcohol 3kg, essence 0.5kg.

[0056] Obtain the patch of dispersion type in the adhesive agent through conventional pressure glue, paste preparation, coating, drying, cutting, packing; Remaining with embodiment 1. Example 3

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Abstract

The present invention relates to a medicine plaster biguanide vanadium complex for curing diabetes. Said invention active complex contains biguanide chelating agent, and it also contains transdermal absorption accelerant, transdermal absorption permeation adjuvant and softening agent.

Description

technical field [0001] The invention belongs to medicines for treating diabetes, in particular to a patch of biguanide vanadium complex for treating diabetes and its application. Background technique [0002] Non-insulin dependent diabetes mellitus (NIDDM for short) is a metabolic disease that affects about 5% to 7% of the population (10% of whom are over 70 years old) in western countries. It is characterized by hyperglycemia and is often accompanied by a number of other symptoms, including hypertension, obesity and lipid dysregulation. The underlying pathology is impaired β-cell function of unknown origin. Insulin resistance, which precedes and predicts impaired glucose tolerance, may be the cause of β-cell dysregulation, or it may simply reveal the presence of a major β-cell defect. [0003] Existing treatments are basically based on oral or injection drugs. [0004] Oral drugs have many defects. The drug is affected by the physiological factors of the gastrointestinal...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K31/28A61P3/04A61P3/06A61P3/10A61P9/12
Inventor 乐益徐亮
Owner 乐益
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