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Fleabane extract and dicaffeoylquinic acid medicine composition and its application

A technology of caffeoylquinic acid and breviscapine, which is applied in the field of medicine and can solve problems such as effects that have not been reported yet

Inactive Publication Date: 2004-02-25
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The medicinal composition of breviscapine and caffeoylquinic acid has been reported in patent literature for the prevention and treatment of various ischemic cardiovascular and cerebrovascular diseases, senile dementia, hyperlipidemia, and viral hepatitis (Chinese patent CN01115358.X, published in 2002), but the effect of breviscapine and dicaffeoylquinic acid composition in the prevention and treatment of acute and chronic liver diseases has not been reported

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Example 1: Extracting breviscapine and dicaffeoylquinic acid from breviscapine

[0032] Take 50kg of whole scutellaria breviscapus, grind it into fine powder and extract with 95% ethanol, recover the ethanol to dry the extract, add water to suspend, extract with ethyl acetate and divide it into upper and lower layers, the upper layer is ethyl acetate, and the lower layer is water layer. The aqueous layer liquid was adjusted to pH 9 with 20% NaOH and left overnight, filtered to remove the precipitate, and the filtrate was adjusted to pH 6 with HCl to obtain the precipitate. The precipitate was dissolved in methanol, recrystallized in chloroform, and dried to obtain scutellarin, weighing 32 g.

Embodiment 2

[0033] The ethyl acetate layer was concentrated and passed through a polyamide column, eluted with dilute ethanol, tracked by TLC, collected the part with an Rf value of 0.5, concentrated to obtain the dicaffeoylquinic acid part, and weighed 46g after drying. Embodiment 2: the preparation of powder injection. Weigh 10g of breviscapine and 10g of dicaffeoylquinic acid, dissolve them with an appropriate amount of water for injection, add 1000ml-5000ml of water for injection, and add 30-40g of mannitol at 30°C to adjust the pH to 8.5, and the solution After sterile filtration, the filtrate was divided into 1000 5ml vials, freeze-dried, and capped to obtain the powder injection of the composition.

Embodiment 3

[0034] Example 3: Tablet preparation. Weigh 20g of breviscapine, 2g of dicaffeoylquinic acid, 40g of starch, and 3g of dextrin, mix well, add 10% starch slurry to make soft material, pass through a 14-mesh nylon sieve, ventilate and dry at 60-70°C, and sieve through a 16-mesh sieve granules, add 1.0g of magnesium stearate and 3g of sodium carboxymethyl starch, mix evenly, press into 1000 tablets, and coat them.

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PUM

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Abstract

The present invention relates to a medicine composition formed from breviscapine which is effective component extracted from Chinese medicinal material erigeron breviscapus and cynarin and its new application for curing acute and chronic hepatitides. The breviscapine and cynarin are mixed according to a certain proportion, and proper auxiliary material can be added, and can be made into various preparations for curing and preventing the diseases of fibrosis of liver, cirrhosis of liver and fatty liver, etc.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to the application of a composition of breviscapine and dicaffeoylquinic acid in treating acute and chronic liver diseases. Background technique [0002] Breviscapine is a kind of active ingredient isolated from the dried whole plant of Asteraceae breviscapine. A large number of studies have shown that breviscapine has good cardiovascular activity. Many preparations such as "breviscapine tablets", "breviscapine Huasu injection" has been clinically used to treat diseases such as cerebral ischemia and stroke. However, there are few reports on other pharmacological activities of breviscapine. Regarding the effect on the liver, it is reported that breviscapine injection can reduce the inflammatory response of carbon tetrachloride to the liver of rats. (Journal of Lanzhou Medical College, 1999, 25(6): 28-30) [0003] Dicaffeoylquinic acid is commonly found in Chinese herba...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K31/7048A61P1/16
Inventor 张川张卫东苏娟周耘
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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