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Nano granules of solid lipid of tanshinone and its preparation method

A technology of solid lipid nanometer and tanshinone, which is applied in the directions of liposome delivery, pharmaceutical formulations, and medical preparations containing active ingredients, etc., can solve problems such as small targeting effect of injections, low bioavailability, and influence on therapeutic effects.

Inactive Publication Date: 2004-03-10
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the solubility of tanshinone in water is very small, and the bioavailability of common preparations containing tanshinone, such as tablets, capsules, etc., is not high, and the targeting effect of its injections is small, which affects the therapeutic effect of the drug

Method used

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  • Nano granules of solid lipid of tanshinone and its preparation method
  • Nano granules of solid lipid of tanshinone and its preparation method
  • Nano granules of solid lipid of tanshinone and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] 10 mg of tanshinone (containing 30% of tanshinone IIA) and 100 mg of stearic acid were dissolved in acetone, and 200 mg of soybean lecithin was dissolved in a small amount of ethanol, and the two parts were mixed to form an organic phase. 350 mg of Poloxamer 188 was dissolved in redistilled water to form the aqueous phase. The organic phase at 75°C was slowly injected into the aqueous phase at the same temperature (75°C) with a syringe, and stirred at constant temperature until a transparent system was formed. The clear system was evaporated under reduced pressure on a rotary evaporator to remove the organic solvent and concentrated to 2 / 3 volume. The concentrated system is quickly mixed in an aqueous phase at 0-2° C., stirred and cooled for 2 hours to form a suspension of solid lipid nanoparticles. Filter through a microporous membrane to remove large particles, and store at 4°C.

[0055] Detection: The average particle size of tanshinone solid lipid nanoparticles wa...

Embodiment 2

[0057] 10 mg of tanshinone (containing 40% of tanshinone IIA), 150 mg of glycerol monostearate and 300 mg of soybean lecithin were dissolved in ethanol to form an organic phase. 300 mg of Cremophor EL (polyoxyethylene castor oil) was dissolved in redistilled water to form the aqueous phase. The organic phase at 75° C. was slowly injected into the aqueous phase at the same temperature with a syringe, and stirred at constant temperature until a transparent system was formed. The clear system was evaporated under reduced pressure with a rotary evaporator to remove the organic solvent and concentrated to 1 / 4 volume. The concentrated system is quickly mixed in an aqueous phase at 0-2° C., stirred and cooled for 2 hours to form a suspension of solid lipid nanoparticles. Filter through a microporous membrane to remove large particles, and store at 4°C.

[0058] Detection: The average particle size of tanshinone solid lipid nanoparticles was 110.0 nm, and the encapsulation efficienc...

Embodiment 3

[0060] 12 mg of tanshinone (containing 70% of tanshinone IIA), 90 mg of stearic acid and 30 mg of stearyl alcohol were dissolved in isopropanol, and 400 mg of soybean lecithin was dissolved in a small amount of ethanol, and the two parts were mixed to form an organic phase. Dissolve 300 mg of Tween-80 in redistilled water to form the aqueous phase. The organic phase at 75° C. was slowly injected into the aqueous phase at the same temperature with a syringe, and stirred at constant temperature until a transparent system was formed. The clear system was evaporated under reduced pressure on a rotary evaporator to remove the organic solvent and concentrated to 2 / 5 volume. The concentrated system is quickly mixed in an aqueous phase at 0-2° C., stirred and cooled for 2 hours to form a suspension of solid lipid nanoparticles. Filter through a microporous membrane to remove large particles, and store at 4°C.

[0061] Detection: The average particle size of tanshinone solid lipid na...

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Abstract

A solid lipoid nanoparticle of tanshinone is prepared from tanshinone, medicinal phosphatide, emulsifier, lipoid material and additive. Its advantages are high dissolving speed and biological utilization rate, high target property to myocardial tissue, high curative effect, low dosage and low toxic by-effect.

Description

technical field [0001] The invention relates to a tanshinone solid lipid nanoparticle preparation, a fat-soluble component of Danshen, and a preparation method of the preparation. Background technique [0002] Tanshinone is a lipid-soluble active ingredient extracted from the traditional Chinese medicine Salvia miltiorrhiza, and its molecular structure contains the structure of ortho-quinone or para-quinone. Quinones are easily reduced and converted into diphenol derivatives, which are then oxidized to quinones. Pharmacological studies have shown that tanshinone has natural antioxidant properties, cardiovascular pharmacological effects, antibacterial and anti-inflammatory effects, and also has obvious anti-tumor effects (Liang Yong, Yang Yiming, Yuan Shulan. Tanshinone Pharmacological Effects and Clinical Research Progress. Chinese Herbal Medicine. 2000, 31(4):304-306). Among them, tanshinone IIA is one of the main effective components of Salvia miltiorrhiza in the treatme...

Claims

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Application Information

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IPC IPC(8): A61K9/127A61K9/14A61K31/343A61P9/10
Inventor 刘建平杜志永
Owner CHINA PHARM UNIV
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