Carboxymethyl chitosan / carboxymethyl cellulose operative antiblocking film and method for making the same

A technology of carboxymethyl chitosan and carboxymethyl cellulose, which is applied in the directions of surgery, surgical drugs, pharmaceutical formulations, etc., can solve the problems of increasing production costs and prices, difficult and expensive use of anti-adhesion films, etc.

Inactive Publication Date: 2004-03-17
DALIAN YONGXING MEDICAL MATERIAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the film still uses expensive sodium hyaluronate and a relatively complicated covalent cross-linking reaction, which increases its production cost and price
Although polylactic acid and polycaprolactone series materials are biocompatible and biodegradable, due to their lack of flexibility, it is difficult to use them as anti-adhesion films

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] (1), according to the colorimetric method determination of " Pharmacopoeia of the People's Republic of China " (2000 edition) regulation, the heavy metal content of commercially available powdery carboxymethyl chitosan (substitution degree is 1.0) as raw material, assay result is higher than 10mg / kg (10ppm), so it is refined according to the following procedures: first prepare 1N hydrochloric acid with redistilled distilled water and concentrated hydrochloric acid, add absolute ethanol to the 1N hydrochloric acid to prepare 150ml of ethanol / hydrochloric acid solution with a volume ratio of 7:3, and store at room temperature Next, put 25g of carboxymethyl chitosan into the above solution and soak for 30min, transfer it to the filter cup of the sand core filter, filter it with a water circulation pump, and wash the carboxymethyl chitosan in the filter cup with 5×150ml 50% ethanol aqueous solution. Sugar five times, suction filtration; transfer carboxymethyl chitosan to a ...

Embodiment 2

[0036] (1), getting commercially available degree of substitution is the powdery carboxymethyl chitosan of 1.0, according to the colorimetric method determination heavy metal content of " Pharmacopoeia of the People's Republic of China " (2000 edition) regulation, assay result is higher than 10mg / kg (10ppm ), so it is refined according to the following procedures: first prepare 1N hydrochloric acid with redistilled distilled water and concentrated hydrochloric acid, add absolute ethanol to this 1N hydrochloric acid to prepare 120ml of ethanol / hydrochloric acid solution with a volume ratio of 7:3, at room temperature, distill 20g Carboxymethyl chitosan is put into the above-mentioned solution and soaked for 20min, transferred to the filter cup of sand core filter, filtered by water circulation pump, and carboxymethyl chitosan in the filter cup is washed five times with 5×120ml 50% ethanol aqueous solution, Suction filtration; transfer carboxymethyl chitosan to a beaker, add 120m...

Embodiment 3

[0043] (1), getting commercially available degree of substitution is the powdered carboxymethyl chitosan of 0.8, and measures its heavy metal content according to the colorimetric method of " Pharmacopoeia of the People's Republic of China " (2000 edition) regulation, and assay result is higher than 10mg / kg (10ppm), refined according to the following procedures: first prepare 1N hydrochloric acid with redistilled distilled water and concentrated hydrochloric acid, then prepare 200ml of ethanol / hydrochloric acid solution by volume ratio 7:3 with dehydrated alcohol and the prepared 1N hydrochloric acid, at room temperature, Put 33g of carboxymethyl chitosan into the above solution and soak for 40min, transfer it to the filter cup of the sand core filter, filter with water circulation pump, and wash the carboxymethyl chitosan in the filter cup with 5×180ml 50% ethanol aqueous solution. time, suction filtration; carboxymethyl chitosan is transferred to the beaker, add 200ml 75% eth...

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PUM

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Abstract

The present invention belongs to the field of medical material science. The post-operation stick preventing carboxymethyl chitosan / carboxymethyl cellulose film is prepared through the process including compounding water solution of carboxymethyl chitosan and carboxymethyl cellulose separately with pure water, filtering, forming film with mixed water solution of carboxymethyl chitosan and carboxymethyl cellulose, drying, crosslinking the film in water solution of Ca ion and / or Fe ion, or Ca ion and Al ions to prepare the post-operation stick preventing film. The film is biocompatible, biodegradable inside body, wide applicable, high in antisticking effect and favorable to post-operation restore, and the preparation process is simple.

Description

technical field [0001] The invention relates to multivalent ion cross-linked carboxymethyl chitosan, carboxymethyl chitosan / carboxymethyl cellulose anti-surgical adhesion film and a preparation method thereof, belonging to the field of medical material science. Background technique [0002] Adhesions occur in almost all surgeries. The proportion of surgical adhesions is as high as 60% to 90%. Abdominal surgical adhesions in mild cases can cause abdominal pain, and in severe cases can cause intestinal obstruction. Gynecological pelvic surgery causing pain or infertility. Surgical adhesions in the heart, brain, and tendons can also cause serious sequelae. Adhesions often require secondary surgery to remove, but new adhesions can recur after removal. Adhesion is not only one of the factors that cause the health deterioration and even death of surgical patients, but also leads to the reduction of medical efficiency and the increase of medical expenses. [0003] The main rea...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/04
CPCA61L31/042A61L31/041A61P41/00C08L1/26C08L5/08
Inventor 张连仲王淑琴冯博智
Owner DALIAN YONGXING MEDICAL MATERIAL
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