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Bougie for treating virus hepatitis and preparing method thereof

A technology for viral hepatitis and suppository, which is applied in the field of suppository for treating viral hepatitis and its preparation, can solve the problems of inconvenient administration, aggravating the burden on the liver of hepatitis patients, and large side effects.

Inactive Publication Date: 2004-04-21
武汉同药物业管理有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These medicines are generally in the form of injections or oral preparations, and there are generally disadvantages such as inconvenient administration, high price, large side effects, and rebound after curing.
Injection has the problem of inconvenient administration; after oral administration is absorbed through the gastrointestinal tract, the drug must be detoxified by the liver, which reduces the efficacy of the drug and increases the burden on the liver of patients with hepatitis. At the same time, the drug also has certain toxic side effects on the liver , thus making the liver worse

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0087] Example 1: A suppository based on semi-synthetic fatty acid glycerides. Take 885g of semi-synthetic fatty acid glyceride, heat it to 65°C to melt it, add 100g of monomethyl glycyrrhizinate that has been crushed through a 100-mesh sieve, 50g of lentinan, 150g of acyclovir, and 15g of sodium caprate, and stir well. Fill the mold at about 50°C, cool to form, demould, and pack to get the product. 1000 suppositories of the present invention are obtained altogether, each weighing 1.2g.

Embodiment 2

[0088] Embodiment 2: A suppository based on semi-synthetic fatty acid glycerides. Take 900g of semi-synthetic fatty acid glyceride, heat it to 70°C to melt it, transfer it to the opened colloid mill while it is hot, add 150g of monomethyl glycyrrhizinate, 50g of lentinan, 90g of acyclovir, and sodium caprate 10g, circulate and grind for 15 minutes, discharge the material, transfer it to the suppository automatic filling machine, adjust the grain weight to 1.2g, fill it into PVC / PE composite embolism capsule, cool, heat seal, cut, and pack. Make 1000 suppositories of the present invention, every grain weighs 1.2g.

Embodiment 3

[0089] Example 3: Suppositories with cocoa butter as the base. Take 857g of cocoa butter, heat it to 50°C to melt it, transfer it to the colloid mill while it is hot, turn on the colloid mill, add 200g of monomethyl glycyrrhizinate, 45g of lentinan, 135g of acyclovir, 13g of sodium caprate, Circulate grinding for 15 minutes, discharge, transfer to suppository automatic filling machine, adjust grain weight to 1.25g, fill into PVC / PE composite suppository, cool, heat seal, cut and pack to obtain. 1000 suppositories of the present invention, each weighing 1.25g.

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PUM

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Abstract

A compound suppository for treating viral hepatitis by applying it through rectum contains monomethyl glycerrhetate, lentinan, acyclovir and liposoluble matrix. Its advantages are high curative effect, low toxic by-effect, no recurrence and low cost.

Description

technical field [0001] The invention relates to a compound suppository of traditional Chinese and western medicine, in particular to a suppository for treating viral hepatitis by rectal administration and a preparation method thereof. Background technique [0002] Viral hepatitis is a common and multiple infectious disease, especially hepatitis B has about 120 million patients in our country. Although there are many types of drugs for treating hepatitis B on the market, only a few types of drugs such as interferon and lamivudine are effective. These medicines generally adopt the dosage form of injection or oral preparation, and there are ubiquitous deficiencies such as inconvenient administration, high price, large side effects, and rebound after curing. Injection has the problem of inconvenient administration; after oral administration is absorbed through the gastrointestinal tract, the drug must be detoxified by the liver, which reduces the efficacy of the drug and increa...

Claims

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Application Information

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IPC IPC(8): A61KA61K9/02A61K31/715A61P1/16A61P31/12
Inventor 韩昌志
Owner 武汉同药物业管理有限公司
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