Glicetin -1 slow release microspheric preparation and its use
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
- Publication Date
- 2004-09-01
- Estimated Expiration
- Not applicable · inactive patent
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Abstract
Description
technical field
[0001] The invention relates to the technical field of medicine, and relates to a sustained-release microsphere preparation of glucagon-like peptide-1 (GLP-1) and an application thereof. Background technique
[0002] Glucagon-like peptide-1 (GLP-1) is a polypeptide secreted by the secretory cells of the small intestine and large intestine and the nerve cells of the brain. It consists of 37 amino acids, and its amino acid sequence is: His- Asp-Glu-Phe-Glu-Arg-His-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys- Glu-Phe-Lle-Ala-Trp-Leu-Val-Lys-Gly-Arg-Gly. (Lopez LC, Frazier ML, Su C-J, et al. Mammalian pancreatic proglucangon contains three glucanguon-related peptides. Proc Nalt Acad Sci USA 1983, 80:5485-5489). GLP-1 can stimulate the secretion of insulin, and can inhibit the secretion of glucagon, reduce fasting or postprandial blood sugar, its role has been confirmed in clinical studies of healthy humans ...