Cinnarizone self micro emulsified soft capsule and its preparation method
A self-micro-emulsifying, cinnarizine technology, applied in the field of medicine, can solve the problems of reduced bioavailability and reduced drug dissolution, and achieve the effects of reducing individual differences, improving curative effect, and improving bioavailability
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[0032] Example 1:
[0033] The composition of the prescription is as follows: (g)
[0034] Cinnarizine 25
[0035] Dimethyl isosorbide 100
[0036] Oleic acid 50
[0037] Tween 80 185
[0038] Vitamin E 5
[0039] A total of 1000 soft capsules
[0040] Preparation process: Cinnarizine self-microemulsifying capsules Preparation method: Weigh an appropriate amount of cinnarizine, add the prescription amount of dimethyl isosorbide, Tween 80, and oleic acid, in a constant temperature shaking bath at 40C, 100 rpm Shake for about 1.5 hours to dissolve, then add antioxidants and stir evenly. After the liquid drops to room temperature, press to form a capsule.
[0041] The dissolution rate of the cinnarizine self-microemulsifying capsules prepared according to Example 1 was compared with commercially available tablets and capsules: the prepared homogeneous solution was filled into hard capsules according to the prescription amount, and the commercially available cinnarizi...
Example Embodiment
[0044] Example 2:
[0045] The composition of the prescription is as follows: (g)
[0046] Cinnarizine 25
[0047] Dimethyl isosorbide 130
[0048] Oleic acid 55
[0049] Tween 80 185
[0050] Vitamin E 5
[0051] A total of 1000 soft capsules
[0052] The preparation process is the same as in Example 1.
Example Embodiment
[0053] Example 3:
[0054] The composition of the prescription is as follows: (g)
[0055] Cinnarizine 25
[0056] Dimethyl isosorbide 150
[0057] Oleic acid 38
[0058] Tween 80 190
[0059] Vitamin E 5
[0060] A total of 1000 soft capsules
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