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Orally disintegrating tablet of corydalis rhizome and its preparation

A technology of orally disintegrating tablets, free of total alkaloids in summer, applied in pharmaceutical formulations, medical preparations containing active ingredients, pill delivery, etc., can solve the problems of inconvenient taking, high frequency of administration, and low bioavailability, etc. To achieve the effect of taking convenience and improving bioavailability

Inactive Publication Date: 2004-12-29
JIANGXI HERBI SKY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The Xiawu tablets sold in the market are prepared by traditional technology, with slow dissolution and low bioavailability; oral administration for water supply, 4-6 tablets at a time, 3 times a day, a large dosage and high frequency of administration; Inconvenient to move and inconvenient to take

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Embodiment 1: No total alkali 7.5g in summer

[0020] β-cyclodextrin 30g

[0021] Microcrystalline Cellulose 130g

[0022] Cross-linked polyvinylpyrrolidone 30g

[0023] Magnesium Stearate 1.5g

[0024] Stevioside 1g

[0025] Makes 1000 pieces

[0026] Its preparation process is as follows: in summer, no total alkali solution is concentrated to a certain density, then vacuum-dried to obtain a dry block, air-flow ultra-fine crushing to obtain a 300-mesh fine powder, and the prescription amount β-cyclodextrin is weighed for inclusion, and then the prescription amount micro Crystalline cellulose, cross-linked polyvinylpyrrolidone, magnesium stearate and stevioside are mixed, and pressed into 1000 tablets under low pressure.

Embodiment 2

[0027] Embodiment 2: No total alkali 7.5g in summer

[0028] β-cyclodextrin 40g

[0029] Microcrystalline Cellulose 130g

[0030] Croscarmellose Sodium 21g

[0031] Micronized silica gel 1g

[0032] Aspartame 0.5g

[0033] Makes 1000 pieces

[0034] Its preparation process is as follows: in summer, no total alkali solution is concentrated to a certain density, then vacuum-dried to obtain a dry block, air-flow ultra-fine crushing to obtain a 300-mesh fine powder, and the prescription amount β-cyclodextrin is weighed for inclusion, and then the prescription amount micro Crystalline cellulose, cross-linked polyvinylpyrrolidone, micropowder silica gel, and aspartame are mixed and pressed into 1000 tablets under low pressure.

Embodiment 3

[0035] Embodiment 3: No total alkali 7.5g in summer

[0036] Mannitol 165g

[0037] Low-substituted hydroxypropyl cellulose 25g

[0038] Magnesium Stearate 1.5g

[0039] Stevioside 1g

[0040] Makes 1000 pieces

[0041] Preparation method: Weigh the prescribed amount of mannitol, add it to the summer total alkali-free solution concentrated to a certain density to dissolve, then spray dry to obtain a dry powder, and then weigh the prescribed amount of low-substituted hydroxypropyl cellulose, magnesium stearate, stevia Glycosides are added to dry powder and mixed, and compressed into 1000 tablets under low pressure.

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PUM

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Abstract

The orally disintegrating decumbent corydalis tablet of the present invention includes total decumbent corydalis alkaloid in 1-20 weight portions, stuffing 100-300 weight portions, disintegrating agent 5-100 weight portions, flow assistant 1-10 weight portions and corrective 0.5-5 weight portions. It is prepared through direct tabletting and spray drying process. The orally disintegrating decumbent corydalis tablet of the present invention is superior to available orally taken decumbent corydalis preparation, and has raised bioavailability. Its taking needs no drinking water and it may be disintegrated fast with saliva only, so that it may be taken conveniently.

Description

technical field [0001] The invention relates to a traditional Chinese medicine preparation, in particular to a Xiawu orally disintegrating tablet and a preparation method thereof. Background technique [0002] Xia Wu is an authentic medicinal material in Jiangxi. It is the dried tuber of Corydalis decumbensc (Thunb.) Pers, a plant of the family Papaveraceae. It is now included in the 2000 edition of the "Chinese Pharmacopoeia". For stroke hemiplegia, bruises, rheumatoid arthritis, sciatica. Domestic research on summer began in the 1970s. After more than 30 years of extensive research, it has been shown that its main active ingredients are alkaloids, including protopine, dehydrocorydine, d-tetrahydropalmatine, Coryline, palmatine, berberine, jatrorrhizine, etc. Pharmacological studies have shown that summer alkaloids have the effects of increasing myocardial nutritional blood flow, expanding peripheral blood vessels, cerebrovascular and lower extremity blood vessels, resist...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/4738A61P19/02A61P25/02A61P29/00
Inventor 黄建荣徐发红黄经球喻志标
Owner JIANGXI HERBI SKY CO LTD