Nano microball of shombycin protein and preparation process thereof

Abstract

The invention belongs to a fully new nano microsphere and its preparing method, applying bionano technique in preparing course, making fibroin self-mount on proper conditions to form nano microsphere, without adding in any initiator, surfactant, cross-linking agent, etc in the whole preparing course, thus completely solving the problem that existing traditional carried drug nano microsphere preparing method introduces the above substances to have latent menaces to human bodies. The preparing process is simple and easy to apply, able to prepare monodisperse nano microsphere with particle size 80-2000nm, and the prepared nano microsphere has good stability and redispersion property, and can be stored for a long time.

Description

technical field

[0001] The invention belongs to the fields of nanotechnology, polymer chemistry, biochemistry, protein, medicine and biotechnology, and in particular relates to a natural biomacromolecule-silk protein nano-microsphere and a preparation method thereof. Background technique

[0002] Silk is one of the earliest natural proteins used by humans. It is a protein fiber composed of silk protein (70-80%) and sericin. It has been used in the textile industry as a natural fiber with excellent performance. In recent years, with the rapid development of biomedical technology, silk protein has been widely used in many fields such as health care products, medicine, biotechnology, and fine chemical industry due to its good biocompatibility, non-antigenicity, and easy degradability. , such as medical sutures, tissue engineering, medical dressings, smart hydrogels, drug-loaded slow-release films, and biosensors. The present inventors have mixed silk protein solution with urea...