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Bone repairing material with calcium and phosphor base and its preparation method

A calcium-phosphorus salt and bone repair technology, applied in medical science, prostheses, etc., can solve the problems of high price, poor biocompatibility, and inability to be biodegraded, and achieve obvious effects and wide application value

Inactive Publication Date: 2005-01-26
TSINGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Some of these fibers are not biodegradable, some are expensive, and some have poor biocompatibility
There is no report on the use of chitin / chitosan fibers to reinforce bone repair materials, especially large bone repair materials

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] The ground calcium oxide (CaO) and monocalcium phosphate (MCPM) powders were mixed in proportion according to the following equation (1). Cut the chitin fiber into short fibers with a length of 3 mm, and mix them in the powder at 0.1% by weight. In 1 mL of 1M phosphate buffer (made with NaH 2 PO 4 and Na 2 HPO 4 12H 2 (0 preparation) add phosphorylated chitin and 0.01% bone morphogenic protein rhBMP-2 respectively accounting for calcium oxide (CaO) and calcium dihydrogen phosphate (MCPM) powder gross weight 0.1%, after stirring, mix with chitin-containing fiber The solid powder is mixed evenly, and the solid-liquid ratio is 0.96.

[0026] (1)

Embodiment 2

[0028] The ground Ca(OH) 2 Mix with calcium hydrogen phosphate (DCPD) powder according to the following equation (2). Cut the chitin fiber into short fibers with a length of 6mm, and mix them in the powder at a weight ratio of 5%. in 1 mL of 1M Na 2 HPO 4 The aqueous solution is added to account for Ca(OH) 2 And calcium hydrogen phosphate (DCPD) powder total weight 1% phosphorylated chitosan and 0.05% bone morphogenic protein rhBMP-2, after stirring evenly, grind carefully with the solid powder of chitin fiber in a mortar, the solid-liquid ratio is 2.29.

[0029] (2)

Embodiment 3

[0031] Mix equimolar tetracalcium phosphate (TTCP) and calcium hydrogen phosphate (DCPA) fine powder, add chitin fibers to 5% of the total weight ratio of tetracalcium phosphate (TTCP) and calcium hydrogen phosphate (DCPA) fine powder, and add a length of 10mm Chitin fiber, mixed evenly. Add 1.0% phosphorylated chitosan (degree of deacetylation: 60%; degree of substitution: 0.50; ×10 3 ) and 0.1% bone morphogenic protein rhBMP-2, after stirring evenly, the sodium phosphate buffer solution containing phosphorylated chitosan and bone morphogenic protein rhBMP-2 was mixed according to the solid-to-liquid ratio (P / L) of 4:1. Mix well in the bowl. The slurry can be injected directly into the bone defect site.

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Abstract

The invention relates to a biological tissue material and its preparation, in particular to a calcium phosphor salt base bone repairing material and its preparation. Said material provided by the invention contains calcium phosphor salt and chitin / chitosan fiber, which existes in form of fiber thread or fiber bunch. It can also be combined with 0.1-10% chitin derivants like chitosan, phosphorylate chitin, phosphorylate chitosan, carboxylation sulation chitosan and or 0.01-0.1% collagen, bone formation protein amethopterin or adriacin. Cell experiments and animal experiments all indicate that the material has favorable biological compatibility and induction activity for osteogenesis. It can raise averagely 1 to 10 times of flexural resistant intensity of calcium phosphor base bone repairing material. The invention is a reliable in vivo degradable material for tissue repairing and treatment.

Description

technical field [0001] The invention relates to a biological tissue repair material, in particular to a bone repair material and a preparation method thereof. Background technique [0002] Chitin, also known as chitin, chitin, chitin, shell protein, etc., is a linear amino polysaccharide insoluble in water, alkali and conventional solvents that maintains and protects the bodies of crustaceans and microorganisms. In the wings or shells of pods (spiders, crustaceans) and the cell walls of fungi and algae, nearly one billion tons are biosynthesized every year, only in the crustacean waste after processing aquatic products such as crabs and shrimps. The content of 10-30% is a natural resource with potential value and yet to be developed. Acid-soluble chitosan (Chitosan) is a deacetylated compound of chitin, a derivative of chitin, with a molecular weight of 120,000 to 590,000, and its chemical name is poly(1,4)-2-amino-2-deoxy-β- D-glucan has obvious alkalinity, good biocompat...

Claims

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Application Information

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IPC IPC(8): A61L27/20
Inventor 颜永年王小红张人佶熊卓林峰卢清萍吴任东
Owner TSINGHUA UNIV
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