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Medicinal composition for treating liver disease, its prepration method and use

A composition and drug technology, applied in the direction of drug combination, antiviral agent, alkali/alkaline earth metal chloride active ingredient, etc., can solve the problem of instability of large-volume injections, reduce the chance of pollution, have less side effects, and be convenient for clinical use Effect

Active Publication Date: 2005-02-16
弘和制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It is generally a small-volume injection, which can be dripped with glucose. Since the problem of instability of large-volume injections (large infusions) cannot be solved, there has been no report on the production of large-volume injections since Qianglining Injection came out.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Weigh monoammonium glycyrrhizinate (C 42 h 65 NO 16 2H 2 O) 150g, L-cysteine ​​hydrochloride (C 3 h 7 NO 2 S·HCI·H 2 (2) 75g, sodium chloride 2125g, and anhydrous sodium sulfite 75g, and disodium edetate 7.5g (in order to prepare 1000 bottles of 250ml specification large-capacity injection) for subsequent use. Add 125 liters of water for injection at 90°C to the concentrated preparation tank, add disodium edetate, L-cysteine ​​hydrochloride, sodium chloride, anhydrous sodium sulfite, and monoammonium glycyrrhizinate into the concentrated preparation tank, and stir thoroughly Make it completely dissolved, add activated carbon according to 0.02% of the total volume of the preparation, heat at 90°C, keep warm for 20 minutes, cool down to 40°C, decarbonize and filter the medicinal solution into a dilute tank, add water for injection to the dilute tank Dosing volume, adjusting pH to 6.5±0.1, the liquid medicine is then filtered through the terminal, filled and sealed ...

Embodiment 2

[0037] Weigh monoammonium glycyrrhizinate (C 42 h 65 NO 16 2H 2 O) 200g, L-cysteine ​​hydrochloride (C 3 h 7 NO 2 S·HCI·H 2 (2) 155g, sodium chloride 800g, and anhydrous sodium sulfite 200g, and disodium edetate 20g (for preparing 100000ml small volume injection) for subsequent use. Add 500 liters of water for injection at 85°C to the concentrated preparation tank, add disodium edetate, L-cysteine ​​hydrochloride, sodium chloride, anhydrous sodium sulfite, and monoammonium glycyrrhizinate into the concentrated preparation tank, and stir thoroughly Make it completely dissolved, add activated carbon according to 0.04% of the total volume of the preparation, heat at 80°C, keep warm for 20 minutes, cool down to 45°C, decarbonize and filter the medicinal solution into the dilute preparation tank, and add water for injection to the dilute preparation tank. The volume of the liquid is adjusted to a pH of 6.6, and the medicinal liquid is filtered through a terminal, and filled ...

Embodiment 3

[0039] Weigh 8 g of monoammonium glycyrrhizinate, 5 g of L-cysteine ​​hydrochloride, 4 g of anhydrous sodium sulfite, and 0.4 g of disodium edetate (to prepare 100 freeze-dried powder injections) for subsequent use. Add an appropriate amount of water for injection at 80°C in the preparation tank, add disodium edetate, L-cysteine ​​hydrochloride, anhydrous sodium sulfite, and monoammonium glycyrrhizinate, stir to dissolve, add dextran 40 excipient, and replenish Add water for injection to the dosing volume, adjust the pH value to 6.5, cool down the liquid medicine, and then filter through the terminal, carry out sterilizing filling, freeze-drying, and make a freeze-dried powder injection product.

[0040] serial number

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PUM

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Abstract

The invention discloses a medicine compound for curing hepatitis, which includes following ingredients and proportion: glycyrrhetic acid monoamine 1-200 shares, L-hydrochloric acid cysteine 1-200 shares, and one of sodium chloride, anhydrous sodium sulfite and ethylenediamine sodium acetic acid or the compound of then, the sodium chloride is 1-1000 shares, the anhydrous sodium sulfite is 1-200 shares, the ethylenediamine sodium acetic acid is 1-100 shares; it also discloses the medicine compound and the manufacturing method and the use, the medicine is compound solution, it can be applied to liver poisoning resisting, reduces the transaminase, recovers the functions of cell; it is mainly applied to cure the chronic hepatitis.

Description

technical field [0001] The present invention relates to a pharmaceutical composition for treating liver disease and its application, in particular to a composition composed of monoammonium glycyrrhizinate, L-cysteine ​​hydrochloride, or / and sodium chloride, or / and anhydrous sodium sulfite, or A pharmaceutical composition for curing liver diseases formed by combining two to five drugs with disodium ethylenediamine tetraacetate, its preparation method, and its application in treating chronic persistent hepatitis, chronic active hepatitis and other diseases. Background technique [0002] Hepatitis is a common and frequently-occurring disease. According to incomplete statistics, hepatitis patients and virus carriers account for 10% of the total population in my country. Among them, viral hepatitis is the main type, and viral hepatitis can be divided into: acute hepatitis, chronic hepatitis, severe hepatitis and biliary hepatitis. Chronic hepatitis can be divided into two catego...

Claims

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Application Information

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IPC IPC(8): A61K33/14A61P1/16A61P31/12
Inventor 王建辉
Owner 弘和制药有限公司
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