Itraconazole freeze-dried powder injection and preparing method
A technology for itraconazole and injection, which is applied in the field of itraconazole freeze-dried powder injection and preparation, can solve the problem that the prescription quantity of hydroxypropyl-β-cyclodextrin cannot be inferred, and achieves plump appearance and convenient Clinical use, fast redissolving effect
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Examples
Example Embodiment
[0015] Example 1
[0016] Prescription: Itraconazole 250g
[0017] Hydroxypropyl-β-cyclodextrin 10000g
[0018] Propylene glycol 625ml
[0019] Hydrochloric acid 95ml
[0020] Mannitol 1000g
[0021] Add water for injection to 25000ml
[0022] A total of 1000 pieces
[0023] Preparation method: Stir itraconazole and hydrochloric acid to form a paste, add propylene glycol, and ultrasonically dissolve to form a clear solution. Take another hydroxypropyl-β-cyclodextrin and add an appropriate amount of water for injection, stir to dissolve, pour the itraconazole propylene glycol solution into the hydroxypropyl-β-cyclodextrin solution, stir until clear, add mannitol, stir Dissolve, adjust the pH to 4.5 with sodium hydroxide to make up the amount of water, ultrafiltration, aliquot, and freeze-dry. Vacuum freeze-drying conditions:
[0024] 1) Pre-freezing: Put the packaged drugs on the partition in the freeze-drying box for pre-freezi...
Example Embodiment
[0027] Example 2
[0028] Prescription: Itraconazole 250g
[0029] Hydroxypropyl-β-cyclodextrin 12500g
[0030] Propylene glycol 625ml
[0031] Hydrochloric acid 95ml
[0032] Add water for injection to 25000ml
[0033] A total of 1000 pieces
[0034] Preparation method: Stir itraconazole and hydrochloric acid to form a paste, add propylene glycol, and stir to dissolve into a clear solution. Take another hydroxypropyl-β-cyclodextrin and add appropriate amount of water for injection and stir to dissolve, pour the itraconazole propylene glycol solution into the hydroxypropyl-β-cyclodextrin solution, stir until clear, adjust with sodium hydroxide The pH is 4.5 to make up the water, ultrafiltration, aliquoting, and freeze-drying. Vacuum freeze-drying conditions:
[0035] 1) Pre-freezing: Put the packaged drugs on the partition in the freeze-drying box for pre-freezing, the product temperature drops to -45°C, and after holding for 3.5 hours,...
Example Embodiment
[0038] Example 3
[0039] Prescription: Itraconazole 250g
[0040] Hydroxypropyl-β-cyclodextrin 15000g
[0041] Propylene glycol 625ml
[0042] Hydrochloric acid 95ml
[0043] Add water for injection to 25000ml
[0044]A total of 1000 pieces
[0045] Preparation method: Stir itraconazole and hydrochloric acid to form a paste, add propylene glycol, and stir to dissolve into a clear solution. Take another hydroxypropyl-β-cyclodextrin and add appropriate amount of water for injection and stir to dissolve, pour the itraconazole propylene glycol solution into the hydroxypropyl-β-cyclodextrin solution, stir until clear, adjust with sodium hydroxide The pH is 4.5 to make up the water, ultrafiltration, aliquoting, and freeze-drying. Vacuum freeze-drying conditions:
[0046] 1) Pre-freezing: Put the packaged drugs on the partition in the freeze-drying box for pre-freezing, the product temperature drops to -45°C, and after holding for 3.5 hours, it can be...
PUM
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap