Magnetic microparticle operation controller

A manipulator and particle technology, which is applied to instruments, scientific instruments, sampling, etc., can solve the problems that the structure of the micro-solenoid coil is not compact enough, the particle control device is difficult to be widely used, and the processing technology is complicated, so as to achieve convenient and flexible design and improve the Control sensitivity, simple process effect

Inactive Publication Date: 2005-06-08
INST OF ELECTRICAL ENG CHINESE ACAD OF SCI
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Problems solved by technology

However, the processing of this micro-solenoid coil requires two steps of photoresist modeling, two copper electroplating and one electroplating of permeable alloy. The processing technology is complicated and the processing cost is relatively high.
In addition, the structure of the micro-solenoid coil is not compact enough. When it is integrated into a micro-tota

Method used

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  • Magnetic microparticle operation controller
  • Magnetic microparticle operation controller

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Embodiment Construction

[0013] figure 1 It is a specific embodiment of the present invention. The key structures of the present invention are planar micro-coils and magnetic micro-tips, wherein the planar micro-coils 4 are processed on the back side of a double-sided polished substrate 3-such as a silicon wafer, glass sheet, GaAs sheet-, and the magnetic micro-tips 2 are processed on the substrate. On the front side of the sheet 3 , the magnetic core 1 is located in the center of the planar microcoil 4 and connected to the magnetic microtip 2 through the substrate 3 . The function of the magnetic core 1 is to concentrate the applied electromagnetic field generated by the planar microcoil on the magnetic microtip 2 .

[0014] The processing process of the magnetic particle manipulator of the present invention is as follows: at first, on the back side of the substrate 3, process the welding plate 5 and the lead wire 6 of the planar microcoil 4 by the method of copper electroplating, the welding plate ...

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Abstract

A magnetic particle controller relates to function device making use of magnetic force to control magnetic ball, cell biological molecule and other particles, comprising plate micro coil integrated on front and reverse sides of one substrate, magnetic micro magnetic core and magnetic tip. When electric current passing through the plate micro coil, electromagnetic field is created near it and magnetic particles near the magnetic micro tip will be absorbed onto it, when the electricity is cur off, the particles will be released since the magnetic field force has disappeared. The method of making plate micro coil only relates to a modeling of photoresist and a copper electroplating course , the process is simple and convenient. Including magnetic ball, cell biological molecule and other particles as objections , the invention can be used alone and also as a part to integrate a micro complete analysis system., with the functions of controlling a single particle, counting a single particle values, screening or separating particle mixture, it can be applied in the fields such as cell biology, immunology analysis, micro fluid research and millimicron technology.

Description

technical field [0001] The invention relates to a magnetic particle manipulator, in particular to a functional device for manipulating particles such as magnetic beads, cells, and biomolecules by using magnetic force. Background technique [0002] The micro-total analysis system is also called lab-on-a-chip, which integrates three steps of sample preparation, biochemical reaction and result detection on a single device, and can perform specific analysis functions. As a highly integrated system, the micro-total analysis system consists of many components, including microfluidic channels, micropumps, microvalves, particle manipulators, etc. Among them, the particle manipulator can manipulate magnetic beads, cells, biomolecules and other particles with sizes ranging from microns to nanometers in a microfluidic environment. [0003] Dielectrophoresis, electroosmosis, ultrasound, magnetism and other physical phenomena can be used to manipulate particles. Among them, using a mag...

Claims

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Application Information

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IPC IPC(8): G01N1/00
Inventor 王明
Owner INST OF ELECTRICAL ENG CHINESE ACAD OF SCI
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