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Composite medicine of honey suckle extractive, scutellaria root extractive and acetaminopher and preparation process thereof

A technology for acetaminophen and honeysuckle extract is applied in the field of combination medicines of honeysuckle and scutellaria baicalensis extract and acetaminophen and the preparation thereof, can solve the problems of difficulty in achieving both symptoms and inconvenience in use, and achieves enhancement of body immunity. force, little gastrointestinal irritation, and the effect of blocking calcium ion channels

Inactive Publication Date: 2005-07-06
张哲峰
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The present invention is aimed at the existing anti-cold preparations of pure traditional Chinese medicine or pure western medicine, which are difficult to treat both superficial and root causes, and are inconvenient to use, and provide a safe, effective, stable, flexible and convenient administration containing honeysuckle and scutellaria baicalensis extracts and acetaminophen Combination drugs to better play the advantages of such drugs in the prevention and treatment of colds, fevers, headaches and other diseases

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Embodiment 1: preparation method of honeysuckle extract

[0014] Take 5kg of honeysuckle, decoct twice, add 30kg of water each time, decoct for 1.5 hours, combine the decoction, filter, concentrate the filtrate to a clear paste with a relative density of 1.20-1.25 (70-80°C), cool to 40°C , slowly add ethanol under stirring to make the alcohol content reach 75%, let it stand for 12 hours, filter the supernatant, recover the ethanol, add ethanol to the concentrated solution to make the alcohol content reach 85%, fully stir, let stand for 12 hours, Filter the supernatant, recover ethanol until there is no alcohol smell, adjust the pH value to 7.0-7.5 with 0.1M sodium hydroxide solution, concentrate under reduced pressure at 60°C to form a thick paste, dry at low temperature, and pulverize to obtain the final product.

[0015] Get honeysuckle 5kg, soak overnight with 30kg ethanol-water (1: 1) solution, reflux extraction twice, 9 hours for the first time, 7 hours for the sec...

Embodiment 2

[0016] Embodiment 2: preparation method of Scutellaria baicalensis extract

[0017]Take 10kg of Scutellaria baicalensis, decoct in water three times, add 30kg of water each time, the first time for 2 hours, the second and third times for 1 hour each, combine the decoction, filter, and concentrate the filtrate to a relative density of 1.20-1.25 (70-80°C) At 80°C, add 2M hydrochloric acid solution to adjust the pH value to 1.0-2.0, keep it warm for 1 hour, let it stand for 24 hours, filter, add 6-8 times the amount of water to the sediment, and use 40% hydrogen The sodium oxide solution was used to adjust the pH value to 7.0-7.5. Add an equal amount of ethanol, stir to dissolve, filter, adjust the pH value of the filtrate to 2.0 with 2M hydrochloric acid, keep it at 60°C for 30 minutes, let it stand for 12 hours, filter, wash the precipitate with water until the pH value is 5.0, and continue to wash with 70% ethanol To the pH value of 7.0, add appropriate amount of water to the...

Embodiment 3

[0018] Embodiment 3: tablet preparation

[0019] Raw material dosage

[0020] Honeysuckle extract 25g (converted to chlorogenic acid 1.5g)

[0021] Scutellaria baicalensis extract 40g (calculated as baicalin)

[0022] Acetaminophen 25g

[0023] Lactose 10g

[0024] Starch 5.0g

[0025] Sodium carboxymethyl starch 2.7g

[0026] Magnesium stearate 0.9g

[0027] 10% starch slurry appropriate amount

[0028] Makes 1000 pieces

[0029] Process: (1) The main drug and auxiliary materials are pulverized separately, the main drug is passed through a 120-mesh sieve, and the auxiliary materials are passed through a 100-mesh sieve, and set aside. (2) Accurately weigh the main drug in the prescribed amount and mix it with a part of lactose by the method of equal dilution and addition, and pass through a 100-mesh sieve three times to obtain mother powder. (3) Mix the remaining part of lactose, starch and internally added disintegrant evenly, and pass through an 80-mesh sieve three ...

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Abstract

The invention provides a composite medicine of honey suckle extractive, scutellaria root extractive and acetaminopher and the preparation process, wherein the medicine has the effects of treating common cold, fever, headache, eradicating cold viruses, improving body immunity and alleviating common cold symptoms.

Description

technical field [0001] The invention relates to a medicine with antipyretic, analgesic, heat-clearing and detoxifying effects for treating cold, fever and headache-combined medicine containing honeysuckle and scutellaria baicalensis extracts and acetaminophen and a preparation method thereof. Background technique [0002] Honeysuckle, also known as double flower, honeysuckle flower, etc., is a plant of the genus Lonicera in the Lonicera family. It is a commonly used traditional Chinese medicine, and its unopened flower buds and vine leaves are used as medicine. It has the functions of clearing heat and detoxifying, dispelling wind and reducing swelling. Modern medicine has found that honeysuckle has broad-spectrum antibacterial, anti-virus, anti-inflammatory and antipyretic, liver-protecting, and blood-lipid-lowering effects. Sexual streptococcus, typhoid bacillus, Shigella, Mycobacterium tuberculosis and pneumococcus have inhibitory effect. It is curr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/7048A61P29/00A61P31/00
Inventor 张哲峰
Owner 张哲峰
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