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Compound tornado drop pills

A croissant and compound technology, which is applied in pill delivery, medical formula, nervous system diseases, etc., can solve the problems of hepatic and intestinal first-pass effect bioavailability, long dissolution time limit, and expensive products, so as to be beneficial to labor protection and environmental protection , avoid gastrointestinal irritation symptoms, improve the effect of bioavailability

Inactive Publication Date: 2005-07-06
北京伟力康源医药科技开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because of its obvious therapeutic effect, it has been made into granules, capsules, and tablets, but there is no drop pill formulation to come out.
[0003] Due to preparation technology and other reasons, most oral preparations of drugs have problems such as long dissolution time, low dissolution rate, poor absorption, hepatic and intestinal first-pass effect and low bioavailability after taking, which affect the efficacy of the drug. , also directly affects the therapeutic effect
[0004] In addition, conventional oral dosage forms, such as tablets, capsules, etc., will produce relatively large dust pollution due to the granulation process in the preparation process, which will cause harm to the health of the staff to a certain extent, and will also cause harm to the human body. some pollution to the environment
[0005] Chinese patent No. 01102531.X "nano compound croissant preparation medicine and preparation method thereof" discloses various nano-preparations about compound croissant preparation, also lists drop pill preparation in its claims, but does not include in its description Nothing about the preparation process of Compound Yangjiao Dropping Pills
As we all know, dripping pills, a newly emerging preparation that is especially suitable for traditional Chinese medicine formulations, make it difficult for many traditional Chinese medicine varieties to be made into dripping pills due to the dispersion of their process conditions.
According to the Pharmacopoeia standard provided by this patented technology, the preparation of compound Yangjiao dripping pills cannot be completed at all, so there is no any process data of the compound Yangjiao dripping pills involved in the present invention in the known technical field
Moreover, the manufacturing cost of nano-preparation industry is high, and the product price is expensive, which is not conducive to the non-public medical treatment of the citizen class.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0034] Now with the test of several groups of specific examples and the results thereof, the preparation method of the compound Yangjiao dripping pill of the present invention will be further described.

[0035] Group 1: Tests with a single matrix

[0036] [formula]

[0037] 1. Raw materials: dry powder containing four active ingredients of traditional Chinese medicines such as horns, chuanxiong, angelica, and aconitum extracted according to the method provided in [Preparation of extracts of horns, chuanxiong, angelica, and aconitum (hereinafter collectively referred to as drug extracts);

[0038] 2. Substrate: polyethylene glycol 2000、4000、6000、8000、10000、20000 , polyoxyl 40 stearate, beta cyclodextrin, poloxamer, sodium carboxymethyl starch, sodium lauryl sulfate, stearic acid, sodium stearate, glycerin gelatin, shellac, etc. pharmaceutical carrier;

[0039] 3. Proportion (in g or kg, in parts by weight): drug extract: matrix = 1:1-1:9.

[0040] [test results]

[0041]...

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PUM

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Abstract

The invention discloses a compound tornado drop pill with the function of analgesia for treating hemicrania, vascular headache and nerve pains, which has the advantages of high biological availability, quick-speed medicine release, quick-speed effect, less toxic and side effects, no contamination in production, and low cost of manufacture. The drop pill is prepared from sheep angle containing pharmaceutical active composition, Ligusticum wallichii, dahurian angelica root, Sichuan aconite root extractive as raw material through specific process.

Description

technical field [0001] The present invention relates to a kind of medicinal composition that has calming liver and analgesic effect, and is used for treating migraine, vascular headache, tension headache, and neuralgia. A pure traditional Chinese medicine composition oral preparation. Background technique [0002] According to the ministerial drug standard WS 3 -Compound Yangjiao granule prepared according to the formula and extraction process given in B-2574-97 is a pharmaceutical composition prepared from the extracts of Yangjiao, Chuanxiong, Angelica dahurica, and Aconitum aconitum, and is used for the treatment of migraine , vascular headache, tension headache, and neuralgia are very effective therapeutic drugs, and it is also one of the pure traditional Chinese medicine preparations commonly used in clinic. Therefore be made into granule, capsule, tablet because it has obvious therapeutic effect, but do not have drop pill dosage form to come out so far. [0003] Due ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K35/32A61P25/04A61P25/06
Inventor 曲韵智
Owner 北京伟力康源医药科技开发有限公司