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Assistant hot-pressed packing method for polymethylmethacrylate microflow controlled chip solvent

A polymethyl methacrylate, microfluidic chip technology, applied in measurement devices, instruments, scientific instruments, etc., can solve the problems of easy cracking of the chip, large deformation of the microfluidic channel, easy blockage, etc., and achieve the sample dosage. The effect of less, easy operation and high analysis efficiency

Inactive Publication Date: 2005-07-27
FUDAN UNIV
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Problems solved by technology

The disadvantage is that when the temperature is higher than the glass transition temperature, the microfluidic channel is deformed and easily blocked, which becomes a bottleneck that limits the production and application of polymethyl methacrylate chips [4]
In addition, the chips packaged by pure hot pressing are easy to crack and be scrapped during use

Method used

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  • Assistant hot-pressed packing method for polymethylmethacrylate microflow controlled chip solvent
  • Assistant hot-pressed packing method for polymethylmethacrylate microflow controlled chip solvent
  • Assistant hot-pressed packing method for polymethylmethacrylate microflow controlled chip solvent

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Embodiment Construction

[0021] Further describe the present invention below by embodiment and accompanying drawing:

[0022] 1. Cyclopentanone-assisted hot-press packaging of polymethyl methacrylate microfluidic chips

[0023] (A) The design of the microfluidic chip uses Adobe Illustrator 10.0 software to design the microfluidic channels and solution connection holes of the chip, and uses a high-resolution (3600dpi) laser phototypesetting system to print a mask negative on a polyester transparent film. The width of the microfluidic channel is 50 μm, and the solution connection hole is a circular hole with a diameter of 2 mm, in which the microfluidic channel (separation capillary 2 and sampling capillary 7) and solution holes 1, 4, 5 and 6 (Fig. 1) are transparent, and the remaining Part is black. The positive image of the microfluidic chip is shown in Figure 1. The separation microfluidic channel 2 is 5.0 cm long, and the sampling microfluidic channel 7 is 0.5 cm long, and the distance from the in...

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Abstract

A packaging method includes selecting cyclopentaneous and ice-acetic with low solubility and high boiling point comparing to perspex as adhesive, preparing perspex microflow control chip substrate with microflow channel, drop-coating said adhesive on cover film of perspex and then closing it with substrate, placing them in oven at 75-85 deg.c, bring 1-2 N / cm2 pressure for 10-15 min, on it through two glass plates, cooling it to room temperature to obtain product of perspex microflow control chip.

Description

technical field [0001] The invention belongs to the technical field of biological detection, and in particular relates to a solvent-assisted hot-pressing packaging method for a polymethyl methacrylate microfluidic chip. Background technique [0002] Since Manz and Widmer [1] first proposed the micro total analysis system (μ-TAS) in 1990, it has developed into one of the most cutting-edge scientific and technological fields in the world in just over ten years. As a new interdisciplinary field, its goal is to realize the overall miniaturization, integration and portability of the chemical analysis system from sample processing to detection by means of micro-electromechanical processing (MEMS) technology and biotechnology, which is an important aspect of the development of analytical instruments. direction and frontier. The microfluidic chip is characterized by the structure of the micropipeline network, which is the focus of the development of the current micro-total analysis...

Claims

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Application Information

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IPC IPC(8): B29D99/00G01N33/00
Inventor 陈刚张鲁雁杨芃原江世益
Owner FUDAN UNIV
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