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Biodegradable calcium phosphate/collagen composite materials for medical use and method for preparation thereof

A composite material, calcium phosphate technology, applied in the field of biomedicine, can solve the problems of matching treatment position, bone repair materials can not fully meet the clinical application, etc., and achieve the effect of good biocompatibility, continuously adjustable degradation rate, and tight binding.

Inactive Publication Date: 2005-08-17
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In clinical application, the new bone tissue cannot be well matched with bone repair materials due to differences in treatment objects and treatment positions during the formation of new bone tissue, resulting in bone repair materials that cannot fully meet the needs of clinical applications, and are expected to be degraded Continuously adjustable biomedical materials

Method used

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  • Biodegradable calcium phosphate/collagen composite materials for medical use and method for preparation thereof
  • Biodegradable calcium phosphate/collagen composite materials for medical use and method for preparation thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Dissolve 0.2g of collagen in 400ml of 0.01M hydrochloric acid solution, and stir with a magnetic stirrer at the same time. After the milky white solution is formed, add 0.5g of α-phase tricalcium phosphate / β-phase tricalcium phosphate composite powder into it evenly, and the α-phase phosphoric acid in the composite powder The ratio of tricalcium and β-phase tricalcium phosphate is 1:3, then add 20ml of 0.1% glutaraldehyde solution, continue to stir slowly until white flocculent suspended matter appears, after it is completely deposited, add KOH solution until the pH value is 7, After standing still for 48 hours, the supernatant was removed, and the obtained material was put into a plastic mold with micropores on the surface, cooled in liquid nitrogen for 60 minutes, and then dried in a freeze dryer for 96 hours. After the material was taken out, it was soaked in ethanol for 24 hours × 3 times. Dry it in a freeze dryer for 60 hours, take it out and sterilize it in ethylen...

Embodiment 2

[0026] Dissolve 0.4g of collagen in 100ml of 0.5M acetic acid solution, stir with a magnetic stirrer at the same time, after it dissolves, add 1.0g of amorphous calcium phosphate powder evenly into the collagen solution, then add 8ml of 0.5% glutaraldehyde solution, Stir continuously until white flocculent suspended matter appears, add NH after it is completely deposited 4 OH solution to a pH value of 7, after standing for 36 hours, remove the supernatant, put the obtained material into a plastic mold with micropores on the surface, cool in liquid nitrogen for 30 minutes, then put it into a freeze dryer to dry for 72 hours, put the material into ethanol after taking it out Soak it for 24 hours × 3 times, put it into the freeze dryer again to dry for 48 hours, take it out and sterilize it in ethylene oxide vapor for 3 hours.

Embodiment 3

[0028] 1.5g of carbonate-containing hydroxyapatite / α-phase tricalcium phosphate powder is evenly added to 200ml of collagen solution with a concentration of 3.0mg / ml, and the ratio of carbonate-containing hydroxyapatite to α-phase tricalcium phosphate in the composite powder is 1:1. After stirring evenly, add 6ml of 1% glutaraldehyde solution, continue to stir until white flocculent suspended matter appears, add NaOH solution until the pH value is 6 after it is completely deposited, remove the supernatant after standing for 24 hours, and put the obtained material on the surface The microporous plastic mold was cooled in liquid nitrogen for 10 minutes, and then dried in a freeze dryer for 72 hours. After the material was taken out, it was soaked in ethanol for 24 hours × 3 times, and then dried in a freeze dryer for 48 hours. Sterilize in oxyethane steam for 2h.

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Abstract

The present invention discloses one kind biodegradable medical composite calcium phosphate / collagen material and its preparationpr. The composite calcium phosphate / collagen material consists of nanometer level calcium phosphate in 50-80 wt% and collagen in 20-50 wt%, where the calcium phosphate may be amorphous calcium phosphate, alpha-tricalcium phosphate, beta-tricalcium phosphate, apatite, calcium biphosphate, composite apatite / alpha-tricalcium phosphate powder, composite apatite / beta-tricalcium phosphate powder, or composite alpha-tricalcium phosphate powder / beta-tricalcium phosphate powder. The composite calcium phosphate / collagen material has homogeneously distributed calcium phosphate, close combination between calcium phosphate and collagen, continuously adjustable degradation rate, high biocompatibility and other features, and is especially suitable for use as bone repairing material.

Description

technical field [0001] The invention relates to a biodegradable medical calcium phosphate / collagen composite material and a preparation method thereof, belonging to the technical field of biomedicine. Background technique [0002] The occurrence of various skeletal diseases and accidents has put forward requirements for the regenerative treatment of human bones, teeth and other tissues, which has triggered an upsurge of research workers on medical bone repair materials. Metal materials based on titanium alloys, bioactive phosphate ceramics, and bioglass with some bioactive components have all attracted people's interest, but the defects of these materials, such as biological inertia and inability to be absorbed, have determined They cannot be used more widely. With the deepening of research, composite materials with biodegradable properties have gradually attracted people's attention. After this material is implanted in the body, it will be soaked and absorbed by body flui...

Claims

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Application Information

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IPC IPC(8): A61L31/06C08K3/26C08L89/04
Inventor 翁文剑邹超程逵韩高荣杜丕一沈鸽赵高凌张溪文
Owner ZHEJIANG UNIV
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