Biodegradable calcium phosphate/collagen composite materials for medical use and method for preparation thereof
A composite material, calcium phosphate technology, applied in the field of biomedicine, can solve the problems of matching treatment position, bone repair materials can not fully meet the clinical application, etc., and achieve the effect of good biocompatibility, continuously adjustable degradation rate, and tight binding.
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Embodiment 1
[0024] Dissolve 0.2g of collagen in 400ml of 0.01M hydrochloric acid solution, and stir with a magnetic stirrer at the same time. After the milky white solution is formed, add 0.5g of α-phase tricalcium phosphate / β-phase tricalcium phosphate composite powder into it evenly, and the α-phase phosphoric acid in the composite powder The ratio of tricalcium and β-phase tricalcium phosphate is 1:3, then add 20ml of 0.1% glutaraldehyde solution, continue to stir slowly until white flocculent suspended matter appears, after it is completely deposited, add KOH solution until the pH value is 7, After standing still for 48 hours, the supernatant was removed, and the obtained material was put into a plastic mold with micropores on the surface, cooled in liquid nitrogen for 60 minutes, and then dried in a freeze dryer for 96 hours. After the material was taken out, it was soaked in ethanol for 24 hours × 3 times. Dry it in a freeze dryer for 60 hours, take it out and sterilize it in ethylen...
Embodiment 2
[0026] Dissolve 0.4g of collagen in 100ml of 0.5M acetic acid solution, stir with a magnetic stirrer at the same time, after it dissolves, add 1.0g of amorphous calcium phosphate powder evenly into the collagen solution, then add 8ml of 0.5% glutaraldehyde solution, Stir continuously until white flocculent suspended matter appears, add NH after it is completely deposited 4 OH solution to a pH value of 7, after standing for 36 hours, remove the supernatant, put the obtained material into a plastic mold with micropores on the surface, cool in liquid nitrogen for 30 minutes, then put it into a freeze dryer to dry for 72 hours, put the material into ethanol after taking it out Soak it for 24 hours × 3 times, put it into the freeze dryer again to dry for 48 hours, take it out and sterilize it in ethylene oxide vapor for 3 hours.
Embodiment 3
[0028] 1.5g of carbonate-containing hydroxyapatite / α-phase tricalcium phosphate powder is evenly added to 200ml of collagen solution with a concentration of 3.0mg / ml, and the ratio of carbonate-containing hydroxyapatite to α-phase tricalcium phosphate in the composite powder is 1:1. After stirring evenly, add 6ml of 1% glutaraldehyde solution, continue to stir until white flocculent suspended matter appears, add NaOH solution until the pH value is 6 after it is completely deposited, remove the supernatant after standing for 24 hours, and put the obtained material on the surface The microporous plastic mold was cooled in liquid nitrogen for 10 minutes, and then dried in a freeze dryer for 72 hours. After the material was taken out, it was soaked in ethanol for 24 hours × 3 times, and then dried in a freeze dryer for 48 hours. Sterilize in oxyethane steam for 2h.
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