New piperidine derivative

A technology of piperidine compounds and compounds, applied in the direction of effective components of heterocyclic compounds, digestive system, organic chemistry, etc., can solve problems such as undiscovered
CN1656071AInactive Publication Date: 2005-08-17MITSUBISHI TANABE PHARMA CORP
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
MITSUBISHI TANABE PHARMA CORP
Publication Date
2005-08-17
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention provides a novel piperidine compound of the formula [I]: wherein Ring A represents an optionally substituted benzene ring, Ring B represents an optionally substituted benzene ring, R>1< represents an optionally substituted alkyl group, an optionally substituted hydroxyl group, etc., or a group of the formula: (a) wherein R>11< AND R>12< are the same or different, and each represents hydrogen atom, a substituted carbonyl group, a substituted sulfonyl group, an optionally substituted alkyl group, etc., R>2< represents hydrogen atom, etc., Z represents oxygen atom or a group represented by -N(R>3<)-, R>3< represents hydrogen atom or an alkyl group, etc., R>4< represents hydrogen atom or an alkyl group, etc.,or a pharmaceutically acceptable salt thereof.
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Description

technical field

[0001] The present invention relates to novel piperidine compounds having excellent tachykinin receptor antagonism. Background technique

[0002] Tachykinin is a generic name for a group of neuropeptides, and Substance P (hereinafter referred to as SP), Neurokinin-A, and Neurokinin-B have been known in mammals. These peptides are known to exhibit various types of biological activities by binding to their corresponding receptors (neurokinin-1, neurokinin-2, neurokinin-3) present in the body. Among them, SP is one of those with the longest history among neuropeptides and has been studied in detail. Its presence was confirmed in 1931 in extracts from horse intestines, and it is a peptide containing 11 amino acids, the structure of which was determined in 1971.

[0003] SP widely exists in the peripheral nervous system, and it has physiological activities such as vasodilation, vascular permeability promotion, smooth muscle contraction, nerve hyperexcitability (...

Claims

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