Hydrobromic acid high tortoiseshell component drip pill and its preparation method
A technology of homogenin hydrobromide and dripping pills, which is applied in the fields of pill delivery, pharmaceutical formulations, and medical preparations containing active ingredients, etc. It can solve the problem of first-pass bioavailability of the liver and intestines, which is not conducive to improving the ability of patients to seek medical treatment. Unfavorable to the overall health level and other issues, to achieve the effect of benefiting labor protection and environmental protection, improving bioavailability, and drug safety
Inactive Publication Date: 2005-10-26
北京博诺威医药科技发展有限公司
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Problems solved by technology
[0016] Due to preparation technology and other reasons, most oral preparations of drugs have problems such as long dissolution time, low dissolution rate, poor absorption, hepatic and intestinal first-pass effect and low bioavailability after taking, which affect the efficacy of the drug. , also directly affects the therapeutic effect
In addition, conventional oral dosage forms, such as tablets, capsules, etc., will produce relatively large dust pollution due to the granulation process in the preparation process, which will cause harm to the health of the staff to a certain extent, and will also cause harm to the human body. some pollution to the environment
Furthermore, the production process of conventional oral preparations is complicated and the production cost is high, so that the cost of medication for patients is also increased, which is not conducive to improving the ability of patients to seek medical treatment, and is also not conducive to improving the overall health level of society.
Method used
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[0042] Now with several groups of specific examples, the preparation method of the homogenate hydrobromide dropping pills of the present invention will be further described.
[0043] [Group 1: Trials with a single substrate]
[0044] 1. Homogenin hydrobromide:
[0045] English name: Lappaconitine Hydrobromide Tablets
[0046] Chemical name: (10α, 14α, 16β)-20-ethyl-1,14,16-trimethoxyaconitane-4,8,9-triol 4-[2-(acetylamino)benzoate hydrogen bromate monohydrate.
[0047] 2. Substrate: polyethylene glycol 1000 , polyethylene glycol 4000 , polyethylene glycol 6000 , polyethylene glycol 10000 , polyethylene glycol 20000 , Span 40, polyoxyl 40 stearate, poloxamer, sodium lauryl sulfate, stearic acid, sodium stearate, glycerin gelatin, shellac;
[0048] 3. Proportion: take g or kg as the unit, by weight parts, homogenine hydrobromide: matrix = 1:1~1:9;
[0049]4. Prepare according to the process of [Preparation Method] 4-7, and different specifications of urinadin hydrobromi...
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A dripping pill of sinomontanine A hydrobromate for treating pain and swelling, local anesthesia, cooling, and antipyresis is prepared from the sinomontanine A hydrobromate and pharmacologically acceptable carrier.
Description
technical field [0001] The invention relates to a pharmaceutical composition with analgesic, local anesthesia, hypothermia, antipyretic and detumescence effects, in particular to an oral preparation of a pharmaceutical composition prepared from uricine hydrobromide as a raw material. Background technique [0002] Uconine Hydrobromide Tablets is an oral preparation prepared from Uconine Hydrobromide as a raw material. Pain, especially cancer pain. Because it can improve the patient's systemic symptoms and improve the body's immune indicators, it can be used as an analgesic for surgery and an adjuvant drug for radiotherapy and chemotherapy. , pain after surgery, etc.), and oral tablets that also have good analgesic, antipyretic, and anti-inflammatory effects on colds. After clinical verification, the curative effect is definite, and it is a commonly used drug for clinical and family treatment of such diseases. [0003] The following is part of the content provided by the pro...
Claims
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Inventor 曲韵智徐俊福
Owner 北京博诺威医药科技发展有限公司