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Cefdinir oral disintegration tablet, and its prepn. method

A technology for oral disintegrating tablets and cefdinir, which is applied in the directions of pharmaceutical formulations, medical preparations containing active ingredients, and pill delivery, etc., can solve the problems of cefdinir oral disintegrating tablets, etc. Ease of use

Inactive Publication Date: 2006-01-25
张志生
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But so far, there is no cefdinir orally disintegrating tablet

Method used

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  • Cefdinir oral disintegration tablet, and its prepn. method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0063] Suspend 25g cefdinir in 7.5g hydroxyethyl cellulose aqueous solution to form solution A, then mix and dissolve 2.5g gelatin, 0.5g spices, 64.5g mannitol and 25g sucrose to form solution B, add the formed solution A to Solution B is mixed, diluted with an appropriate amount of water, mixed well, added to the mold and frozen at low temperature, put into a freeze dryer to vacuumize, sublimated from ice until the material is completely dry, sealed and packaged.

[0064] The total weight of the above-mentioned auxiliary materials is 100g, and 1000 tablets are made, each auxiliary material is 100mg, and the main drug is 25mg of cefdinir, that is, the weight of cefdinir orally disintegrating tablets is 125mg.

Embodiment 2

[0066] Mix the main drug cefdinir 50g with glucose 30g, compressible sorbitol 10g, mannitol 20g, sodium bicarbonate 10g, citric acid 9.9g, saccharin sodium 0.05g, aspartame 0.05, add wetting agent or The binder is made into a soft material, sieved, dried, sized, added with a lubricant, and compressed into 1000 tablets, each weighing 150 mg, containing 50 mg of cefdinir and 100 mg of auxiliary materials.

Embodiment 3

[0068] The main drug cefdinir 100g and carboxymethyl starch sodium 10g, compressible starch 60g, crystal cellulose sodium 30g, sodium lauryl sulfate 3g, mannitol 5g, sodium chloride 1g, flavor 0.5g, 0.5 g of spartame was mixed evenly, and directly compressed into tablets after adding a lubricant to make 1000 tablets, each weighing 210 mg, containing 100 mg of cefdinir and 110 mg of auxiliary materials.

[0069] In the above three embodiments, cefdinir 25mg, 50mg, and 100mg are in three specifications altogether, and when preparing this product, the weight of each tablet is variable. When preparing other orally disintegrating tablets containing cefdinir 10-200mg / tablet, the method is the same as above.

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Abstract

An oral disintegrating tablet of Toubaodini is prepared from Toubaodini, filler, disintegration agent, flouring agent, sweeten and appropriate. It features that it can be easily dissolved in saliva.

Description

technical field [0001] The invention relates to an orally disintegrating tablet and a preparation method thereof, more specifically, the invention relates to a cefdinir orally disintegrating tablet and a preparation method thereof. Background technique [0002] Cefdinir is a third-generation cephalosporin antibiotic with the chemical name (-)-(6R,7R)-7-[(Z)-2-(2-amino-4-thiazolyl)-2-hydroxy Imino-acetylamino]-8-oxo-3-vinyl-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid (abbreviated as Cefdinir in English), molecular formula for C 14 h 13 N 5 o 5 S 2 , the structural formula is as follows: [0003] [0004] As a third-generation cephalosporin, cefdinir is effective against G + , G - Bacteria have broad-spectrum antibacterial activity and can inhibit 90-100% of clinical isolates, such as methicillin-sensitive Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus (including Streptococcus pneumoniae), Haemophilus influenzae, Klebsiella pneumoniae co...

Claims

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Application Information

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IPC IPC(8): A61K31/546A61K9/20A61P31/04A61P11/00A61P17/02
Inventor 康秋萍刘春平于联平
Owner 张志生
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