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Multi-channel nerve rehabilitating tube, its preparation process and dedicated mold

A nerve repair and multi-channel technology, applied in the field of preparation of multi-channel nerve repair catheters, can solve problems such as easy separation, unfavorable axons passing through the catheter, complicated operation, etc., achieve stable performance, easy popularization and application, and simple operation process Effect

Inactive Publication Date: 2006-02-08
TSINGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantage of this method is that the resulting matrix structure is disorganized, which is not conducive to the shortest distance for axons to pass through the catheter
However, the operation is more complicated and the efficiency is low. After lyophilization, the silicone tube is easily separated from the internal multi-channel matrix, and the silicone tube cannot be degraded in the body, so a second operation is required to remove it.

Method used

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  • Multi-channel nerve rehabilitating tube, its preparation process and dedicated mold
  • Multi-channel nerve rehabilitating tube, its preparation process and dedicated mold
  • Multi-channel nerve rehabilitating tube, its preparation process and dedicated mold

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] 1) First utilize conventional methods, such as the method of Chinese patent application ZL 02149086.4, to prepare chitosan round tubes with an inner diameter of 1 to 5 mm and a wall thickness of 0.2 to 1.0 mm;

[0022] 2) As attached figure 1 As shown, the chitosan round tube 2 of 5 cm long different diameters is inserted in the hole 1 of corresponding diameter on the mold base 4, injects 4% (w / v) chitosan solution (with 0.2mol / L acetic acid solution). Quickly cover the -20°C pre-cooled stainless steel cover plate 3 on it, put it in the -20°C refrigerator for more than 12 hours, then remove the stainless steel cover plate 3, take out the round tube containing the ice crystal column, put it in a low-temperature container, and freeze-dry Freeze-dry in the machine (the main temperature is about -40 ℃) for more than 24 hours;

[0023] 3) Soak the freeze-dried specimen in step 2) in an aqueous sodium hydroxide solution with a concentration of 2% (w / v) for 30 minutes, take ...

Embodiment 2

[0026] 1) First utilize conventional methods, such as the method of Chinese patent application ZL 02149086.4, to prepare chitosan round tubes with an inner diameter of 1 to 5 mm and a wall thickness of 0.2 to 1.0 mm;

[0027] 2) As attached figure 1As shown, the chitosan round pipe 2 of different diameters with 3cm length is inserted in the hole 1 of corresponding diameter on the mold base 4, then in the chitosan round pipe, inject 4% (w / v) chitosan solution (with 0.2 mol / L acetic acid solution) and 10% gelatin aqueous solution, the mass ratio of the two is 1:1. Quickly cover the -80°C pre-cooled stainless steel cover plate 3 on it, put it in the -80°C refrigerator for more than 12 hours, then remove the stainless steel cover plate 3, take out the round tube containing the ice crystal column, put it in a low-temperature container, and freeze-dry Freeze-dry in the machine (the main temperature is about -40 ℃) for more than 24 hours;

[0028] 3) Soak the freeze-dried specimen ...

Embodiment 3

[0031] 1) First utilize conventional methods, such as the method of Chinese patent application ZL 02149086.4, to prepare chitosan round tubes with an inner diameter of 1 to 5 mm and a wall thickness of 0.2 to 1.0 mm;

[0032] 2) As attached figure 1 As shown, 1 cm long chitosan round tubes 2 of different diameters were inserted into holes 1 of corresponding diameters on the mold base 4, and then injected into the chitosan round tubes 2 in combination with bFGF (20 μg / L), VEGF (20 μg / L ) mixed solution gel of heparin and chitosan, the final concentration of heparin is 1%, and the final concentration of chitosan is 3%. Quickly cover the -80°C pre-cooled stainless steel cover plate 3 on it, put it in the -80°C refrigerator for more than 12 hours, then remove the stainless steel cover plate 3, take out the round tube containing the ice crystal column, put it in a low-temperature container, and freeze-dry Freeze-dry in the machine (the main temperature is about -40 ℃) for more tha...

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Abstract

The invention relates to a multi-path nerve-restoring duct, its manufacturing method and special mould. Wherein, the duct is comprised by a chitose round duct and an internal base material with axial multi-path; the mould is formed by a Styrofoam thermal insulation chassis and a stainless steel cover plate while a plurality of cylindrical holes in different inner diameters are regularly arranged on the thermal insulation chassis and a fine needle hole is arranged on the bottom of holes through to the base of chassis. And the manufacturing method of multi-path nerve restoring duct comprises inserting the chitose round ducts in different diameters into the holes of relative diameter of the mould chassis; filling different filling base material into the chitose round ducts according to the demand; using the pre-cooling stainless steel cover plate to quickly cover the chitose round ducts to be stored in low-temperature refrigerator for more than 12 hours; freezing, drying, deacidifying, and poaching with distilled water to the neutral ones; then to be dried in room temperature to attain the multi-path nerve restoring duct. Said manufacturing process is simple with stable result which applies batch production.

Description

technical field [0001] The invention relates to a preparation method of a multi-channel nerve repair catheter and a special mold thereof, belonging to the technical field of biomedical materials and tissue engineering. Background technique [0002] The current clinical treatment for long-distance peripheral nerve defects is autologous nerve transplantation. However, the source of autologous nerves is limited, and the function of the donor site is impaired. With the development of medicine, biology and tissue engineering, the study of bridging severed nerves with nerve repair catheters has received extensive attention. The epineurium at both stumps and the tube wall were sutured and fixed, and the axons could grow along the tube lumen from the proximal end to the distal end. During nerve regeneration, nerve conduits can prevent the invasion of fibrous scar tissue, increase the concentration of local neurotrophic factors, and guide axonal growth. However, the hollow conduit...

Claims

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Application Information

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IPC IPC(8): A61F2/04A61L27/00A61L29/04
Inventor 敖强张秀芳王爱军公衍道贺庆赵南明
Owner TSINGHUA UNIV
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